9 completed, 8 not yet recruiting, 8 unknown, 5 recruiting. 11 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 4, Not yet recruiting 3, Recruiting 2, Unknown 2 |
| Phase 3 | 1 | Unknown 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Extubation Failure: new trials by email Literature Review of Extubation Failure trials Research Report on Extubation Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Swallowing Assessment for Predicting Extubation Failure in Critically Ill Patients Extubation Failure, Mechanical Ventilation | Not yet recruiting | Universidade Federal de Pernambuco | 800 | 2027-03-30 | 2026-06-22 | |
| One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial One-hour positive pressure ventilation, Immediate extubation - Airway Extubation, Extubation Failure | Not applicable | Not yet recruiting | Hospital do Coracao | 4000 | 2027-01-01 | 2026-09-22 |
| One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial One-hour positive pressure ventilation, Immediate extubation - Airway Extubation, Weaning Mechanical Ventilation | Not applicable | Not yet recruiting | Hospital do Coracao | 4000 | 2027-01-01 | 2026-09-22 |
| Predictors of Extubation Failure in Ventilated Neonates Extubation Failure, Neonates | Not yet recruiting | Assiut University | 124 | 2026-12-01 | 2026-08-14 | |
| Combined RSBI, TOF, and BIS for Prediction of Extubation Success Combined pre-extubation assessment using RSBI, TOF ratio, and BIS - Extubation Success, Extubation Failure | Not yet recruiting | Gaziantep City Hospital | 150 | 2026-10-10 | 2026-10-16 | |
| Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations Biphasic cuirass ventilator which is a type of negative pressure ventilator will be applied to patients on the intervention arm - Respiratory Failure, Extubation Failure | Not applicable | Not yet recruiting | University of Missouri-Columbia | 50 | 2026-10-01 | 2026-07-28 |
| Neonatal Diaphragmatic Activity-Linked Extubation Conditions and Timing Study of Predictors of Successful Extubation in Preterm Infants, Extubation Succeeded | Not yet recruiting | Centre Hospitalier Intercommunal Creteil | 20 | 2026-07-01 | 2026-07-17 | |
| Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes Observational measurement of Cough Peak Flow and Tidal Volume - Extubation Failure | Not yet recruiting | Hospital H+ Queretaro | 150 | 2026-07-01 | 2026-07-30 | |
| Assessment of Reintubation Risk Using Multiple Parameters in Postoperative Intensive Care Unit Patients Postoperative Respiratory Failure, Extubation Failure | Recruiting | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization | 600 | 2026-04-28 | 2026-08-11 | |
| Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit. Mechanical Ventilation, Pulmonary Rehabilitation | Recruiting | Universita degli Studi di Genova | 2400 | 2025-10-01 | 2026-09-15 | |
| Noninvasive Ventilation Versus High-Flow Nasal Cannula After Extubation in High-Risk ICU Patients NIV, HFNC - Extubation Failure | Not applicable | Completed | Benha University | 102 | 2025-07-30 | 2026-06-11 |
| A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score Ventilator Weaning, Respiration, Artificial | Recruiting | Medipol University | 470 | 2025-06-15 | 2026-05-05 | |
| Factors Associated With Extubation Failure in Kanigara ICU (Intensive Care Unit) RSUPN Dr. Cipto Mangunkusumo Not applicable- observational study - Extubation Failure, Ventilated Patients | Completed | Universitas Indonesia | 156 | 2025-03-01 | 2025-06-26 | |
| Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates. PreTerm Neonate, Extubation Readiness | Completed | Centre Hospitalier Intercommunal Creteil | 166 | 2025-02-17 | 2026-09-14 | |
| High-Flow Nasal Cannula After Extubation in Acute Brain Injury Acute Brain Injury, Post-neurosurgical Status | Completed | Bach Mai Hospital | 285 | 2025-01-01 | 2026-09-10 | |
| Risk Factors of Extubation Failure in PICU Patients Extubation Failure | Unknown | Sohag University | 100 | 2024-05-01 | 2024-08-16 | |
| Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients Noninvasive ventilation alternating with high flow nasal cannula, High flow nasal cannula - Obesity, Morbid, Extubation Failure | Not applicable | Recruiting | Rush University Medical Center | 250 | 2023-07-10 | 2026-08-07 |
| Predictive Value of Chest Ultrasound Observation on Extubation Failure Pulmonary Ultrasound - Pulmonary Ultrasound, Weaning Failure | Unknown | University Hospital, Caen | 150 | 2023-05-24 | 2023-07-13 | |
| Ventilation Support for the PREvenTion of EXTubation Failure protocolized postextubation support - Extubation Failure | Not applicable | Unknown | University Hospital, Caen | 1100 | 2022-10-01 | 2022-10-03 |
| Performance of the Variation in Arterial Lactatemia During a Spontaneous Breathing Trial (SBT) in the Prediction of Extubation Failure Extubation Failure | Unknown | Assistance Publique - Hôpitaux de Paris | 242 | 2022-09-15 | 2022-08-15 |
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Respiratory Insufficiency (3) · Bronchopulmonary Dysplasia (2) · Premature Birth (2) · Brain Injuries (1) · Critical Illness (1) · Death (1) · Deglutition Disorders (1) · Obesity, Morbid (1) · Pulmonary Edema (1) · Respiratory Aspiration (1) · Sleep Initiation and Maintenance Disorders (1) · Stroke (1)
Respiratory Tract Diseases (6) · Pathological Conditions, Signs and Symptoms (4) · Lung Diseases (3) · Nervous System Diseases (3) · Pathologic Processes (3) · Respiration Disorders (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Infant, Newborn, Diseases (2) · Infant, Premature, Diseases (2) · Lung Injury (2) · Obstetric Labor Complications (2) · Obstetric Labor, Premature (2)
Positive-Pressure Respiration (2) · Noninvasive Ventilation (1) · Oxygen (1) · Tidal Volume (1)
Centre Hospitalier Intercommunal Creteil (2) · Hospital do Coracao (2) · University Hospital, Caen (2) · All India Institute of Medical Sciences (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Bach Mai Hospital (1) · Benha University (1) · Gaziantep City Hospital (1) · Henrik Endeman (1) · Hospital H+ Queretaro (1) · Hospital Virgen de la Salud (1) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (1) · Marmara University (1) · Medipol University (1)
France (4) · Turkey (Türkiye) (4) · Egypt (3) · Brazil (2) · Italy (2) · Mexico (2) · Spain (2) · United States (2) · Canada (1) · Chile (1) · Germany (1) · India (1) · Indonesia (1) · Iran (1) · Netherlands (1)
Alexy Tran Dinh, PhD (1) · Ary Serpa Neto, MD, PhD (1) · Babak Mokhlesi, MD (1) · Carol L. Hodgson, PhD FACP FAHMS BAppSc(PT) MPhi (1) · Denise Battaglini, MD, PhD (1) · Dennis B Chairman, MD (1) · Elizabeth Foglia (1) · Eren Ozek (1) · Gentle S. Shrestha, MD, PhD (1) · Gonzalo Hernandez (1) · H. Endeman, Dr. (1) · Irene Schiavetti, PhD (1) · Jose de Jesus Rodriguez-Andoney, MD (1)
PMID 11331690, PMID 16224108, PMID 16276167, PMID 16737982, PMID 17762844, PMID 17931878, PMID 18283429, PMID 18511703, PMID 19294365, PMID 19446324, PMID 19467849, PMID 20406507, PMID 21908497, PMID 22417844, PMID 22531566, PMID 22988501, PMID 24247473, PMID 24323843, PMID 25003980, PMID 26975498, PMID 27706464, PMID 27864615, PMID 28860265, PMID 28979394, PMID 31970446, PMID 36286256, PMID 36400984, PMID 38509583, PMID 39514845, PMID 39774863, PMID 8162725