4 completed, 3 not yet recruiting, 2 recruiting, 2 unknown. 11 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 4, Not yet recruiting 3, Recruiting 2, Unknown 2 |
Follow Extubation Failure: new trials by email Literature Review of Extubation Failure trials Research Report on Extubation Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial One-hour positive pressure ventilation, Immediate extubation - Airway Extubation, Extubation Failure | Not applicable | Not yet recruiting | Hospital do Coracao | 4000 | 2027-01-01 | 2026-09-22 |
| One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial One-hour positive pressure ventilation, Immediate extubation - Airway Extubation, Weaning Mechanical Ventilation | Not applicable | Not yet recruiting | Hospital do Coracao | 4000 | 2027-01-01 | 2026-09-22 |
| Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations Biphasic cuirass ventilator which is a type of negative pressure ventilator will be applied to patients on the intervention arm - Respiratory Failure, Extubation Failure | Not applicable | Not yet recruiting | University of Missouri-Columbia | 50 | 2026-10-01 | 2026-07-28 |
| Noninvasive Ventilation Versus High-Flow Nasal Cannula After Extubation in High-Risk ICU Patients NIV, HFNC - Extubation Failure | Not applicable | Completed | Benha University | 102 | 2025-07-30 | 2026-06-11 |
| Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients Noninvasive ventilation alternating with high flow nasal cannula, High flow nasal cannula - Obesity, Morbid, Extubation Failure | Not applicable | Recruiting | Rush University Medical Center | 250 | 2023-07-10 | 2026-08-07 |
| Ventilation Support for the PREvenTion of EXTubation Failure protocolized postextubation support - Extubation Failure | Not applicable | Unknown | University Hospital, Caen | 1100 | 2022-10-01 | 2022-10-03 |
| The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial NIV-NAVA, NS-NIPPV - Extubation Failure, Bronchopulmonary Dysplasia | Not applicable | Recruiting | University of Pennsylvania | 478 | 2022-08-03 | 2026-06-25 |
| Postextubation High-flow Therapy vs Noninvasive Ventilation in Obese or at High-risk Patients Preventive Conditioned NIV Therapy after planned extubation, Preventive HFOT after planned extubation - Extubation Failure | Not applicable | Completed | Hospital Virgen de la Salud | 326 | 2020-06-01 | 2022-03-17 |
| PES to Avoid Extubation Failure in Intubated Stroke Patients at High Risk of Severe Dysphagia Pharyngeal Electrical Stimulation (PES) - Stroke, Dysphagia | Not applicable | Unknown | University Hospital Muenster | 30 | 2018-07-01 | 2019-07-08 |
| Post-extubation High-flow Nasal Oxygen for Preventing Extubation Failure High-flow nasal oxygen, Venturi mask - Extubation Failure | Not applicable | Completed | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 127 | 2017-10-01 | 2019-08-08 |
| Bubble Continuous Positive Airway Pressure (CPAP) With Conventional CPAP for Extubation in Preterm Infants Bubble CPAP, Conventional CPAP - Extubation Failure | Not applicable | Completed | All India Institute of Medical Sciences | 32 | 2007-09-01 | 2013-02-26 |
Bronchopulmonary Dysplasia (1) · Death (1) · Deglutition Disorders (1) · Obesity, Morbid (1) · Respiratory Insufficiency (1) · Stroke (1)
Pathological Conditions, Signs and Symptoms (2) · Respiratory Tract Diseases (2) · Body Weight (1) · Brain Diseases (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1) · Cerebrovascular Disorders (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Diseases (1) · Esophageal Diseases (1) · Gastrointestinal Diseases (1) · Infant, Newborn, Diseases (1) · Infant, Premature, Diseases (1) · Lung Diseases (1) · Lung Injury (1)
Positive-Pressure Respiration (2)
Hospital do Coracao (2) · All India Institute of Medical Sciences (1) · Benha University (1) · Hospital Virgen de la Salud (1) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (1) · Rush University Medical Center (1) · University Hospital Muenster (1) · University Hospital, Caen (1) · University of Missouri-Columbia (1) · University of Pennsylvania (1)
Mexico (2) · United States (2) · Canada (1) · Egypt (1) · Germany (1) · India (1) · Spain (1)
Babak Mokhlesi, MD (1) · Dennis B Chairman, MD (1) · Elizabeth Foglia (1) · Gonzalo Hernandez (1) · Jose de Jesus Rodriguez-Andoney, MD (1) · Mari J Sankar, MD, DM (1) · Rainer Dziewas, MD (1) · Ramandeep Kaur, PhD (1) · Ramesh Agarwal, MD, DM (1) · Sucheta Yadav, MBBS (1) · Vinod K Paul, MD PhD (1)
PMID 11331690, PMID 16224108, PMID 16276167, PMID 16737982, PMID 17762844, PMID 17931878, PMID 19294365, PMID 19467849, PMID 20406507, PMID 21908497, PMID 22417844, PMID 22531566, PMID 22988501, PMID 24323843, PMID 25003980, PMID 26975498, PMID 27706464, PMID 28860265, PMID 36400984, PMID 38509583, PMID 39514845, PMID 39774863, PMID 8162725