11 completed. 11 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Completed 11 |
Follow cyclopia sequence: new trials by email Literature Review of cyclopia sequence trials Research Report on cyclopia sequence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PRF + Minocycline vs Arestin in Non-surgical Perio Therapy Arestin, PRF + M - Non-surgical Periodontal Therapy | Phase 4 | Completed | Center for Advanced Rejuvenation and Esthetics | 15 | 2024-12-01 | 2026-05-28 |
| Optimization of Minocycline for Helicobacter Pylori Rescue Treatment Vonoprazan, Bismuth Potassium Citrate, Tetracycline,Metronidazole - Helicobacter Pylori Infection | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 480 | 2024-08-21 | 2026-03-25 |
| Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy Minocycline - Ischemic Stroke, Acute | Phase 4 | Completed | Xijing Hospital | 189 | 2022-11-01 | 2026-07-29 |
| Rescue Therapy for Helicobacter Pylori Eradication Treatment Esomeprazole, Bismuth Potassium Citrate, Tetracycline,Metronidazole - Helicobacter Pylori Infection | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 368 | 2020-10-15 | 2024-12-30 |
| Minocycline Pharmacokinetics (ACUMIN) Minocycline - Bacterial Infection | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 58 | 2018-03-28 | 2020-12-03 |
| Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Minocycline - PTSD | Phase 4 | Completed | Sriram Ramaswamy | 10 | 2017-05-10 | 2020-07-09 |
| Minocycline Augmentation to Clozapine Minocycline - Schizophrenia, Schizoaffective Disorder | Phase 4 | Completed | Emory University | 10 | 2015-02-01 | 2018-09-26 |
| The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis minocycline, surface and root planning - Chronic Periodontitis | Phase 4 | Completed | Zhejiang University | 70 | 2013-06-01 | 2015-12-02 |
| Minocycline for Bipolar Depression Minocycline - Bipolar Depression | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 20 | 2011-05-01 | 2017-01-30 |
| Minocycline to Treat Childhood Regressive Autism Minocycline - Autism, Minocycline | Phase 4 | Completed | National Institute of Mental Health (NIMH) | 11 | 2006-11-01 | 2015-12-11 |
| Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris Tazarotene 0.1% gel + placebo capsule, Oral minocycline (100 mg capsule) + vehicle gel, Tazarotene 0.1% gel + oral minocycline (100 mg capsule) - Acne Vulgaris | Phase 4 | Completed | KGL, Inc. | 189 | 2002-03-01 | 2005-12-15 |
Acne Vulgaris (1) · Autistic Disorder (1) · Bacterial Infections (1) · Bipolar Disorder (1) · Chronic Periodontitis (1) · Depression (1) · Ischemic Stroke (1) · Mood Disorders (1) · Psychotic Disorders (1) · Schizophrenia (1) · Stress Disorders, Post-Traumatic (1)
Mental Disorders (4) · Acneiform Eruptions (1) · Autism Spectrum Disorder (1) · Bacterial Infections and Mycoses (1) · Behavior (1) · Behavioral Symptoms (1) · Bipolar and Related Disorders (1) · Brain Diseases (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1) · Cerebrovascular Disorders (1) · Child Development Disorders, Pervasive (1) · Chronic Disease (1) · Disease Attributes (1) · Infections (1)
Minocycline (11) · Metronidazole (2) · Tetracycline (2) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (1) · Capsules (1) · Esomeprazole (1) · Gels (1) · Prolactin-Releasing Hormone (1) · tazarotene (1)
Shanghai Jiao Tong University School of Medicine (2) · Center for Advanced Rejuvenation and Esthetics (1) · Emory University (1) · Icahn School of Medicine at Mount Sinai (1) · KGL, Inc. (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institute of Mental Health (NIMH) (1) · Sriram Ramaswamy (1) · Xijing Hospital (1) · Zhejiang University (1)
United States (7) · China (3)
Dan V Iosifescu, MD, MSc (1) · James Leyden, MD (1) · Robert O Cotes, MD (1) · Shuli Deng, Master (1) · Sriram Ramaswamy, MD (1)
PMID 23566357, PMID 26231264, PMID 39806586, PMID 42305108, PMID 42633753
2UM1AI104681-08 (1)