20 completed. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Completed 20 |
Follow Crystal Arthropathies: new trials by email Literature Review of Crystal Arthropathies trials Research Report on Crystal Arthropathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial to Investigate the Non-inferiority of Pegloticase Administered Every 4 Weeks (Q4W) With MTX Compared With Every 2 Weeks (Q2W) With MTX in Participants With Uncontrolled Refractory Gout Pegloticase, Methotrexate - Gout | Phase 4 | Completed | Amgen | 306 | 2024-03-18 | 2026-09-17 |
| Pegloticase and Methotrexate Co-administered in Participants With Uncontrolled Gout Who Previously Failed Pegloticase Monotherapy Pegloticase, Methotrexate (MTX) - Uncontrolled Gout | Phase 4 | Completed | Amgen | 11 | 2021-03-08 | 2024-06-27 |
| A Phase 4, Open-label Study of KRYSTEXXA® (Pegloticase) Co-administered With Methotrexate (MTX) in Patients With Uncontrolled Gout (FORWARD OL) Pegloticase, Methotrexate (MTX) - Uncontrolled Gout, Chronic Gout | Phase 4 | Completed | Amgen | 54 | 2021-01-26 | 2026-05-19 |
| Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate Pegloticase with MTX - Chronic Uncontrolled Gout, Gout | Phase 4 | Completed | Amgen | 191 | 2020-10-02 | 2025-10-20 |
| Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout Pegloticase, methotrexate, placebo - Gout | Phase 4 | Completed | Amgen | 152 | 2019-06-13 | 2024-06-26 |
| Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout Pegloticase, Methotrexate (MTX), Standard Gout Flare Prophylaxis - Gout | Phase 4 | Completed | Amgen | 14 | 2018-09-26 | 2024-06-26 |
| CSP594 Comparative Effectiveness in Gout: Allopurinol vs. Febuxostat allopurinol capsule, 100-800 mg by mouth once daily, febuxostat tablet 40-120 mg by mouth once daily, Placebo, vehicle control (febuxostat-shaped) - Gout, Chronic Kidney Diseases | Phase 4 | Completed | VA Office of Research and Development | 950 | 2017-03-06 | 2024-03-29 |
| Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout Febuxostat 80/120mg/day, Allopurinol 100 up to 600mg/day, Colchicine - Gout | Phase 4 | Completed | Menarini International Operations Luxembourg SA | 196 | 2015-08-17 | 2019-06-21 |
| Optimal Administration of Allopurinol in Dialysis Patients Allopurinol - Gout, Renal Insufficiency | Phase 4 | Completed | Maisonneuve-Rosemont Hospital | 50 | 2015-06-01 | 2016-09-13 |
| Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection Sodium Chloride 0.9%, Methylprednisolone acetate, Ultrasound-guided Needling and Lavage - Calcifying Tendinitis of Shoulder | Phase 4 | Completed | Nantes University Hospital | 136 | 2015-04-04 | 2026-09-14 |
| Colchicine Or Naproxen Treatment for ACute gouT Low-dose colchicine, Naproxen 750 mg/250 mg - Gout | Phase 4 | Completed | Keele University | 399 | 2014-01-01 | 2019-06-18 |
| Effects of Hyperuricemia Reversal on Features of the Metabolic Syndrome Febuxostat - Gout | Phase 4 | Completed | University of Texas Southwestern Medical Center | 24 | 2012-05-01 | 2023-03-14 |
| Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol Colchicine (Colcrys®), placebo, allopurinol - Intercritical Gout | Phase 4 | Completed | Regeneron Pharmaceuticals | 82 | 2011-10-01 | 2014-05-12 |
| Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure Febuxostat - Prehypertension, Gout | Phase 4 | Completed | University of California, San Diego | 47 | 2011-10-01 | 2019-12-16 |
| Allopurinol Outcome Study Allopurinol - Gout | Phase 4 | Completed | Ardea Biosciences, Inc. | 1735 | 2011-07-01 | 2014-06-17 |
| An Assessment of Chronic Synovial-Based Inflammation and Its Role With Serum Urate Levels. Magnetic Resonance Imaging, Febuxostat, Colchicine - Gout | Phase 4 | Completed | University of South Florida | 74 | 2010-05-01 | 2019-08-07 |
| Postmarketing Study to Determine Performance of the SIGMA HP® PARTIAL KNEE SYSTEM SIGMA HP PARTIAL KNEE - Osteoarthritis, Post-traumatic Arthritis | Phase 4 | Completed | DePuy International | 64 | 2009-01-01 | 2016-05-30 |
| Does Allopurinol Prolong a Treated, Acute Gout Flare? allopurinol, Placebo (sugar pill) - Gout | Phase 4 | Completed | 59th Medical Wing | 35 | 2007-12-01 | 2018-02-14 |
| Efficacy of Proprietary Cherry Juice Blend in Osteoarthritis of the Knee proprietary cherry juice blend (food), control juice (kool aid blend) - Osteoarthritis | Phase 4 | Completed | CherryPharm | 59 | 2007-03-01 | 2012-08-03 |
| Initiation of Allopurinol at First Medical Contact for Acute Attacks of Gout Allopurinol, Placebo - Gout, Gout Acute | Phase 4 | Completed | White River Junction Veterans Affairs Medical Center | 57 | 1998-01-01 | 2011-03-08 |
Gout (19) · Osteoarthritis (2) · Arthritis (1) · Cardiovascular Diseases (1) · Chondrocalcinosis (1) · Hypertension (1) · Hyperuricemia (1) · Inflammation (1) · Pain (1) · Prehypertension (1) · Renal Insufficiency (1) · Renal Insufficiency, Chronic (1) · Rotator Cuff Tear Arthropathy (1)
Joint Diseases (20) · Musculoskeletal Diseases (20) · Arthritis (19) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (19) · Genetic Diseases, Inborn (19) · Metabolic Diseases (19) · Metabolism, Inborn Errors (19) · Nutritional and Metabolic Diseases (19) · Purine-Pyrimidine Metabolism, Inborn Errors (19) · Rheumatic Diseases (19) · Pathological Conditions, Signs and Symptoms (3) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Kidney Diseases (2)
Allopurinol (7) · Methotrexate (6) · Pegloticase (6) · Febuxostat (5) · Colchicine (4) · Folic Acid (2) · Naproxen (2) · Acetaminophen (1) · Food (1) · Magnetic Resonance Spectroscopy (1) · Methylprednisolone (1) · Methylprednisolone Acetate (1) · Omeprazole (1) · Sodium Chloride (1) · Sugars (1)
Amgen (6) · 59th Medical Wing (1) · Ardea Biosciences, Inc. (1) · CherryPharm (1) · DePuy International (1) · Keele University (1) · Maisonneuve-Rosemont Hospital (1) · Menarini International Operations Luxembourg SA (1) · Nantes University Hospital (1) · Regeneron Pharmaceuticals (1) · University of California, San Diego (1) · University of South Florida (1) · University of Texas Southwestern Medical Center (1) · VA Office of Research and Development (1) · White River Junction Veterans Affairs Medical Center (1)
United States (15) · Canada (2) · Germany (2) · Italy (2) · Australia (1) · Belgium (1) · France (1) · Netherlands (1) · New Zealand (1) · Poland (1) · Romania (1) · Serbia (1) · South Africa (1) · Switzerland (1) · United Kingdom (1)
Claudio Borghi, Prof (1) · Daniel O'Connor, UCSD (1) · Ed Roddy (1) · Ernesto J Rodriguez, MD (1) · H. R Schumacher, M.D. (1) · James R O'Dell (1) · Jason T. Davis, M.D. (1) · Jay B Higgs, MD (1) · John D Carter, MD (1) · Naim M Maalouf, MD (1) · S Baumgartner, MD (1) · Supra Verma, MD (1)
PMID 23098865, PMID 26190562, PMID 30975645, PMID 31666237, PMID 32877573, PMID 32934137, PMID 33719606, PMID 34438469, PMID 35293984, PMID 35434725, PMID 35835008, PMID 36008814, PMID 36099211, PMID 36575505, PMID 37842953, PMID 38260556, PMID 38447697, PMID 38766125, PMID 39426967, PMID 39678124, PMID 42775939
2014 (1)