127 completed, 41 unknown, 21 recruiting, 11 not yet recruiting. 67 Phase 2, 38 Phase 1, 35 Not applicable, 28 Phase 4, 18 Phase 3.
Follow Hyperuricemia: new trials by email Literature Review of Hyperuricemia trials Research Report on Hyperuricemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Screening for Hyperuricemia in Patients With Metabolic Associated Fatty Liver Disease (MAFLD) Hyperuricemia and MAFLD | Not yet recruiting | Assiut University | 200 | 2026-11-01 | 2026-01-13 | |
| Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks No intervention; observational assessment only - Obesity & Overweight, Diabetes Mellitus, Type 2 | Not yet recruiting | Shanxi Bethune Hospital | 25974 | 2026-11-01 | 2026-10-21 | |
| Combined Metabolic Activator Supplementation in Subjects Diagnosed With Gout Combined metabolic activators, Collagen and maltodextrin - Gout Disease | Phase 3 | Not yet recruiting | ScandiBio Therapeutics AB | 336 | 2026-10-01 | 2026-10-27 |
| Mazdutide for Weight Management and Gout in Adults With Obesity Mazdutide - Gout, Obesity (BMI>30) | Phase 4 | Not yet recruiting | Hongwei Jiang | 30 | 2026-09-15 | 2026-09-17 |
| SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial Empagliflozin 10 mg, Placebo - Gout and Hyperuricemia | Phase 4 | Recruiting | Massachusetts General Hospital | 60 | 2026-07-01 | 2026-08-05 |
| A Study of IN026 in Participants With Refractory Gout IN026 Injection - Refractory Gout | Phase 1 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 16 | 2026-06-12 | 2026-07-31 |
| Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss Collection of gingival crevicular fluid (GCF) and serum samples, Measurement of periodontal clinical parameters - Periodontal Diseases, Hyperuricemia | Recruiting | Recep Tayyip Erdogan University Training and Research Hospital | 80 | 2026-06-10 | 2026-06-26 | |
| Tart Cherry Citrate Effervescent Tablet for Urate-Lowering Therapy in Participants With Asymptomatic Hyperuricemia tart cherry citrate effervescent table, Placebo Control Group - Hyperuricemia With or Without Gout | Not applicable | Recruiting | Beijing Zhecheng Biotechnology Co., Ltd. | 196 | 2026-06-04 | 2026-06-17 |
| Comparison of the Effect of Allopurinol Versus Febuxostat on Serum Uric Acid in Patients With Chronic Kidney Disease Associated With Hyperuricemia Febuxostat, allopurinol - Hyperuricemia, Renal Insufficiency, Chronic | Not applicable | Active not recruiting | Nishtar Medical University | 66 | 2026-05-13 | 2026-09-30 |
| Probiotic-Uricase Complex Preparation for Improving Uric Acid Metabolism in Patients With Hyperuricemia Probiotic-uricase complex preparation - Hyperuricemia, Gout | Not applicable | Not yet recruiting | Maanshan Shiqiye Hospital | 45 | 2026-05-01 | 2026-05-29 |
| Acute Effects of a Urate-lowering Bacterial Therapeutic on Small Intestinal Transcriptomics and Glycomics in Healthy Subjects BEO001 Probiotic, BEO001 Probiotic + Beta-Glucan, Placebo - Healthy, Hyperuricemia, Gout | Not applicable | Active not recruiting | Örebro University, Sweden | 8 | 2026-04-09 | 2026-10-20 |
| Chronic Kidney Disease and Metabolic Disorders in the Elderly Chronic Kidney Diease, Diabetes Mellitus | Not yet recruiting | Chinese PLA General Hospital | 100000 | 2026-04-01 | 2026-03-27 | |
| Clinical Trial of BR2251 Tablets for Patients With Primary Gout and Hyperuricemia BR2251, Febuxostat - Gout and Hyperuricemia | Phase 2 | Not yet recruiting | BioRay Pharmaceutical Co., Ltd. | 160 | 2026-04-01 | 2026-03-27 |
| The Efficacy and Safety of SHR4640 Tablet Combined With 40 mg Febuxostat Tablets in the Treatment of Primary Gout and Hyperuricemia SHR4640 ；Febuxostat, SHR4640 ; Febuxostat, SHR4640 - Primary Gout and Hyperuricemia | Phase 2 | Recruiting | Jiangsu HengRui Medicine Co., Ltd. | 340 | 2026-02-09 | 2026-04-07 |
| HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat - Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis | Phase 4 | Not yet recruiting | Haiphong University of Medicine and Pharmacy | 228 | 2026-01-20 | 2026-01-27 |
| A Study to Investigate the Clinical Effect and the Safety of PRX-115 Infused Intravenously at Different Dosing Regimens, With and Without Methotrexate, Versus Placebo in Adults Gout Patients (RELEASE) PRX-115, Methotrexate (MTX), PRX-115 placebo - Gout | Phase 2 | Recruiting | Protalix | 150 | 2025-12-22 | 2026-09-29 |
| Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients AR882 75 mg, XOI Low Dose, XOI High Dose - Gout, Gouty Arthritis | Phase 2 | Active not recruiting | Arthrosi Therapeutics | 15 | 2025-12-03 | 2026-05-15 |
| Hyperuricemia as Early Indication of CKD Progressing in Prediabetic CKD Progression | Not yet recruiting | Assiut University | 150 | 2025-10-01 | 2025-09-30 | |
| Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level ., *Imaging Studies:* 1- Ultrasound 2 - FibroScan, Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests. - Hyperuricemia, NAFLD (Nonalcoholic Fatty Liver Disease) | Not yet recruiting | Assiut University | 111 | 2025-10-01 | 2025-09-15 | |
| A Study of Dotinurad Versus Allopurinol in Tophaceous Gout Allopurinol, Dotinurad - Tophaceous Gout | Phase 3 | Recruiting | Crystalys Therapeutics | 250 | 2025-08-04 | 2026-09-28 |
Showing 20 of 223. Sign in to see all of them.
Gout (97) · Renal Insufficiency, Chronic (15) · Hypertension (12) · Metabolic Syndrome (12) · Obesity (11) · Arthritis, Gouty (10) · Diabetes Mellitus (8) · Diabetes Mellitus, Type 2 (7) · Inflammation (7) · Leukemia (6) · Lymphoma (6) · Non-alcoholic Fatty Liver Disease (6) · Arthritis (5) · Cardiovascular Diseases (5)
Pathologic Processes (223) · Pathological Conditions, Signs and Symptoms (223) · Nutritional and Metabolic Diseases (128) · Metabolic Diseases (121) · Musculoskeletal Diseases (100) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (98) · Crystal Arthropathies (98) · Genetic Diseases, Inborn (98) · Metabolism, Inborn Errors (98) · Purine-Pyrimidine Metabolism, Inborn Errors (98) · Joint Diseases (97) · Rheumatic Diseases (97) · Arthritis (94) · Glucose Metabolism Disorders (29) · Female Urogenital Diseases and Pregnancy Complications (27)
Allopurinol (35) · Febuxostat (35) · rasburicase (12) · ruzinurad (10) · dotinurad (7) · Benzbromarone (6) · Colchicine (6) · Urate Oxidase (5) · arhalofenate (4) · ulodesine (4) · Prednisone (3) · Tablets (3) · verinurad (3) · Injections (2) · Naproxen (2)
Jiangsu HengRui Medicine Co., Ltd. (11) · LG Chem (10) · Sanofi (8) · Takeda (7) · Arthrosi Therapeutics (6) · Allena Pharmaceuticals (5) · Assiut University (5) · Shanghai 10th People's Hospital (5) · AstraZeneca (4) · BioCryst Pharmaceuticals (4) · Gilead Sciences (4) · Atom Therapeutics Co., Ltd (3) · Fuji Yakuhin Co., Ltd. (3) · Hebei Medical University (3) · Instituto Nacional de Cardiologia Ignacio Chavez (3)
United States (75) · China (47) · Taiwan (14) · Japan (13) · France (7) · Australia (6) · Italy (6) · South Korea (6) · Georgia (5) · New Zealand (5) · Spain (5) · Turkey (Türkiye) (5) · Germany (4) · Mexico (4) · Poland (4)
Hyungjin Cho, MD (3) · Robert Keenan, MD (3) · Alan Hollister, MD, PhD (2) · Anthony S Fiorino, MD, PhD (2) · C Tosone, MS, RAC (2) · Cheng-Wei Liu, M.D. (2) · Ling Wang, MD, PhD (2) · Magdalena Madero, MD (2) · R Keenan, MD (2) · Vijay Hingorani, MD, PhD, MBA (2) · A. Ahsan Ejaz, MD (1) · Ai Peng, MD, PhD (1) · Ai Peng, Ph.D., M.D. (1)
PMID 21849262, PMID 39929260, PMID 12421831, PMID 12535399, PMID 12867348, PMID 15698861, PMID 16331766, PMID 16620352, PMID 18349746, PMID 19076979, PMID 19286847, PMID 19933411, PMID 20370912, PMID 21353107, PMID 22015451, PMID 22052584, PMID 22132950, PMID 22172492, PMID 22316106, PMID 22436129, PMID 22795277, PMID 22995041, PMID 23006736, PMID 23395281, PMID 23683134, PMID 24393558, PMID 25935771, PMID 26894653, PMID 26903390, PMID 27005768, PMID 27457514, PMID 27477556, PMID 27713240, PMID 27980008, PMID 28270924, PMID 28975718, PMID 29527974, PMID 29643150, PMID 30485934, PMID 30545672, PMID 30601717, PMID 30844048, PMID 31033362, PMID 31037275, PMID 31151457, PMID 31734820, PMID 31754882, PMID 31758246, PMID 31792640, PMID 32391934
2025 (2), 2014 (1), K23HL148394 (1), R01DK103729 (1), R21DK071223 (1), R21DK105401 (1), R61AR084188 (1)