6 completed, 3 not yet recruiting, 1 enrolling by invitation, 1 recruiting. 6 Not applicable, 2 Early Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 4, Not yet recruiting 2 |
| Early Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 1 | Enrolling by invitation 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Craniotomy Surgery: new trials by email Literature Review of Craniotomy Surgery trials Research Report on Craniotomy Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sphenopalatine Ganglion Block Combined With Either Scalp Nerve Block or Local Wound Infiltration for Postoperative Analgesia in Adult Patients Undergoing Craniotomy: A Randomized Controlled Trial Group (c): control group patients will receive general anesthesia., Group (SS): Sphenopalatine Ganglion Block with either Scalp Nerve Block, Group (SL): patients will receive Sphenopalatine Ganglion Block with local wound infiltration - Craniotomy Surgery | Not applicable | Not yet recruiting | Zagazig University | 54 | 2026-10-30 | 2026-10-21 |
| Effects of Ultrasound-Guided Scalp Block on Opioid Use, Hemodynamics, and Postoperative Inflammation in Craniotomy Craniotomy Surgery | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 60 | 2026-04-10 | 2026-04-22 | |
| Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy Dexamedomedine, MgSO4 - Craniotomy Surgery | Not applicable | Not yet recruiting | Assiut University | 60 | 2025-10-20 | 2025-09-30 |
| When to Block? Timing of Scalp Block in Craniotomy pre-pinning group, pre-emergence Group - Scalp Block, Regional Anesthesia | Not applicable | Completed | Sakarya University | 60 | 2025-07-01 | 2026-07-09 |
| Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery Remifentanil, Methadone - Brain Injury, Brain Tumors | Early Phase 1 | Recruiting | University of Virginia | 40 | 2025-03-10 | 2026-05-04 |
| Evaluation of Response to Pain From Skull Pin Fixation in Craniotomies Scalp nerve block, Opioid Anesthetics, Local Anesthetic Injection - Electroencephalography, Craniotomy Surgery | Completed | Diskapi Teaching and Research Hospital | 120 | 2025-02-28 | 2026-09-25 | |
| A Comparative Analysis of Combined Superficial Cervical Plexus and Supraorbital Blocks Compared to Scalp Blocks During Craniotomy: a Review of Opioid Consumption and The Suppression of Hemodynamic Responses Combination of superficial cervical plexus block and supraorbital block, Scalp block with bupivacaine alone - Craniotomy Surgery, Regional Anaesthesia | Not applicable | Completed | Universitas Indonesia | 41 | 2025-02-18 | 2025-08-19 |
| Effectiveness of 3D Bone Matrix in Cranioplasty OsteoprintCR, SMAR SET GMV Endurance Gentamicin - Cranioplasty, Craniotomy | Phase 3 | Enrolling by invitation | Universidad Austral de Chile | 8 | 2024-07-01 | 2025-01-27 |
| The Effect of Bundle Application on Surgical Site Infection The Surgical Site Infections Precaution Package Form includes the parameters that should be applied to patients before, during and after surgery. - Craniotomy Surgery, Preventive Health Care | Not applicable | Completed | Cukurova University | 102 | 2024-01-01 | 2024-12-09 |
| The Efficacy of Regional Scalp Block in Craniotomy nerve block with 0.5% ropivacaine, General anesthesia and opioids (fentanyl, propofol, rocuronium) - Scalp Nerve Block, Craniotomy Surgery | Early Phase 1 | Completed | Universitas Airlangga | 40 | 2023-10-01 | 2024-12-06 |
| The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position General Anesthesia, Anesthetic Agents, mechanical ventilation (MV) - Craniotomy Surgery, Pediatric Patient Safety | Not applicable | Completed | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 30 | 2021-01-01 | 2026-01-27 |
| Cranial Blocks for Postoperative Anesthesia Liposomal bupivacaine, Bupivacaine Injection, Saline - Craniotomy Surgery | Phase 4 | Terminated | University of Pennsylvania | 11 | 2020-09-02 | 2023-09-13 |
Agnosia (2) · Brain Injuries (1) · Brain Neoplasms (1) · Craniocerebral Trauma (1) · Cross Infection (1) · Pain (1) · Pain, Postoperative (1) · Surgical Wound Infection (1)
Nervous System Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Neurologic Manifestations (3) · Signs and Symptoms (3) · Neurobehavioral Manifestations (2) · Pathologic Processes (2) · Perceptual Disorders (2) · Postoperative Complications (2) · Trauma, Nervous System (2) · Wounds and Injuries (2) · Brain Diseases (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Craniocerebral Trauma (1) · Disease Attributes (1)
Bupivacaine (3) · Anesthesia, General (2) · Fentanyl (2) · Analgesics, Opioid (1) · Anesthetics (1) · Anesthetics, Local (1) · Methadone (1) · Nerve Block (1) · Population Groups (1) · Postoperative Period (1) · Propofol (1) · Remifentanil (1) · Respiration, Artificial (1) · Rocuronium (1) · Ropivacaine (1)
Assiut University (1) · Cukurova University (1) · Diskapi Teaching and Research Hospital (1) · Dr. Lutfi Kirdar Kartal Training and Research Hospital (1) · Fatih Sultan Mehmet Training and Research Hospital (1) · Sakarya University (1) · Universidad Austral de Chile (1) · Universitas Airlangga (1) · Universitas Indonesia (1) · University of Pennsylvania (1) · University of Virginia (1) · Zagazig University (1)
Turkey (Türkiye) (5) · Indonesia (2) · United States (2) · Chile (1)
Ceyda Ozhan Caparlar, MD (1) · Christijogo Soemartono Waloejo, MD, Ph.D (1) · Erden Sevilay (1) · Timothy H Lucas, MD (1)
PMID 31153358, PMID 11682413, PMID 20878375, PMID 21956040, PMID 25169006, PMID 31461049, PMID 33420848, PMID 35261367, PMID 36227628, PMID 36980200, PMID 3785962, PMID 38262005, PMID 4048757, PMID 41042039, PMID 41613181, PMID 4835444, PMID 8942596