31 completed. 31 Phase 3, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 31 | Completed 31 |
| Phase 2 | 8 | Completed 8 |
Follow Congestive Heart Failure: new trials by email Literature Review of Congestive Heart Failure trials Research Report on Congestive Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety Trial of OPC-61815 Injection in Patients With Congestive Heart Failure Who Have Difficulty With or Are Incapable of Oral Intake OPC-61815 injection - Congestive Heart Failure | Phase 3 | Completed | Otsuka Pharmaceutical Co., Ltd. | 45 | 2019-06-17 | 2021-09-05 |
| Efficacy and Safety Trial of OPC-61815 Injection Compared With Tolvaptan 15-mg Tablet in Patients With Congestive Heart Failure OPC-61815, Tolvaptan Tab 15 MG - Congestive Heart Failure | Phase 3 | Completed | Otsuka Pharmaceutical Co., Ltd. | 294 | 2019-01-16 | 2021-08-05 |
| Inhaled Beta-adrenergic Agonists to Treat Pulmonary Vascular Disease in Heart Failure With Preserved EF (BEAT HFpEF): A Randomized Controlled Trial Albuterol, Saline placebo - Congestive Heart Failure, Heart Failure, Left-Sided | Phase 3 | Completed | Mayo Clinic | 30 | 2016-09-01 | 2019-02-22 |
| Sub-Q Versus IV Furosemide in Acute Heart Failure Furosemide Injection Solution (SCP-101), Furosemide Injection Solution, USP - Congestive Heart Failure | Phase 2 / Phase 3 | Completed | Johns Hopkins University | 40 | 2016-02-01 | 2017-12-18 |
| Blood Pressure Reduction in Heart Failure Hydralazine/amlodipine, Placebo - Heart Failure, Cardiac Failure | Phase 2 / Phase 3 | Completed | University of Sao Paulo | 21 | 2011-01-01 | 2014-06-10 |
| Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive Heart Failure furosemide and hypertonic saline solution, furosemide - Congestive Heart Failure, Renal Insufficiency | Phase 3 | Completed | Aspirus Heart and Vascular Institute-Research and Education | 50 | 2009-11-01 | 2012-02-09 |
| Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failure Aliskiren, Placebo - Acute Decompensated Heart Failure, Congestive Heart Failure | Phase 3 | Completed | Novartis Pharmaceuticals | 1639 | 2009-05-01 | 2013-11-07 |
| Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency tonapofylline, Placebo - Renal Insufficiency, Congestive Heart Failure | Phase 3 | Completed | Biogen | 420 | 2008-07-31 | 2023-09-11 |
| Efficiency Study of Triple-Site Cardiac Resynchronization in Patients With Heart Failure Cardiac resynchronization pacemaker (InSync Sentry or Concerto, Medtronic, Minneapolis, MN,USA) with two intracardiac leads, Triple-site cardiac resynchronization - Congestive Heart Failure, Heart Disease | Phase 2 / Phase 3 | Completed | Silesian Centre for Heart Diseases | 100 | 2008-02-01 | 2016-04-13 |
| Improving Clinician Communication Skills (ICCS) Training Program Intervention - Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD) | Phase 3 | Completed | University of Washington | 6086 | 2007-04-01 | 2014-09-16 |
| Bypass Surgery and CD133 Marrow Cell Injection for Treatment of Ischemic Heart Failure Intramyocardial injection of autologous CD133+ marrow cells - Coronary Artery Disease With Need for Bypass Surgery, Myocardial Ischemia, Angina Pectoris | Phase 2 / Phase 3 | Completed | German Heart Institute | 60 | 2007-04-01 | 2013-01-16 |
| An Open-label, One-arm, Study to Evaluate the Hemodynamic Changes and Safety of Nesiritide for Acute Decompensated Heart Failure Nesiritide - Heart Decompensation, Congestive Heart Failure | Phase 3 | Completed | Xian-Janssen Pharmaceutical Ltd. | 41 | 2006-10-01 | 2014-02-28 |
| RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial Darbepoetin alfa, Placebo - Heart Failure, Anemia | Phase 3 | Completed | Amgen | 2278 | 2006-06-01 | 2022-11-08 |
| A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure carvedilol controlled release, carvedilol immediate release - Congestive Heart Failure | Phase 3 | Completed | CTI-1, LLC | 318 | 2006-03-01 | 2023-03-28 |
| DILIPO (DILutIonal HyPOnatremia) SR121463B - Congestive Heart Failure | Phase 3 | Completed | Sanofi | 150 | 2005-05-01 | 2008-09-15 |
| APAF: Assessment of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation Optimized echo-guided CRT pacing, normal RV pacing - Congestive Heart Failure, Atrial Fibrillation | Phase 3 | Completed | Azienda USL Reggio Emilia - IRCCS | 458 | 2005-05-01 | 2025-06-12 |
| Continuous Positive Airway Pressure for Acute Pulmonary Edema Continuous Positive Airway Pressure (CPAP), usual care of acute pulmonary oedema - Pulmonary Edema, Dyspnea | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 208 | 2004-10-01 | 2010-03-30 |
| EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan Tolvaptan - Congestive Heart Failure | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 3600 | 2003-09-01 | 2012-05-03 |
| Study of Sildenafil in Advanced Heart Failure. sildenafil - Congestive Heart Failure | Phase 3 | Completed | Massachusetts General Hospital | 40 | 2003-05-01 | 2009-08-11 |
| Clinical Study of the EASYTRAK 3 Spiral Fixation Coronary Venous Bipolar Pace/Sense Lead EASYTRAK 3 left ventricular pacing lead - Congestive Heart Failure | Phase 2 / Phase 3 | Completed | Boston Scientific Corporation | 115 | 2003-05-01 | 2007-06-25 |
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Heart Failure (31) · Renal Insufficiency (3) · Ventricular Dysfunction (3) · Anemia (1) · Angina Pectoris (1) · Atrial Fibrillation (1) · Cardio-Renal Syndrome (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1) · Dyspnea (1) · End Stage Liver Disease (1) · Heart Diseases (1) · Hypertension, Pulmonary (1) · Hyponatremia (1) · Kidney Diseases (1)
Cardiovascular Diseases (30) · Heart Diseases (30) · Pathological Conditions, Signs and Symptoms (4) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Lung Diseases (3) · Male Urogenital Diseases (3) · Pathologic Processes (3) · Respiratory Tract Diseases (3) · Urogenital Diseases (3) · Urologic Diseases (3) · Kidney Diseases (2) · Signs and Symptoms (2) · Vascular Diseases (2) · Arrhythmias, Cardiac (1)
Carvedilol (3) · candesartan (3) · candesartan cilexetil (3) · Furosemide (2) · Natriuretic Peptide, Brain (2) · Sildenafil Citrate (2) · Tolvaptan (2) · 1,3-dipropyl-8-(2-(5,6-epoxy)norbornyl)xanthine (1) · Albuterol (1) · Amlodipine (1) · BG 9928 (1) · Cardiac Resynchronization Therapy (1) · Continuous Positive Airway Pressure (1) · Darbepoetin alfa (1) · Defibrillators (1)
AstraZeneca (3) · Boston Scientific Corporation (3) · Massachusetts General Hospital (2) · Mayo Clinic (2) · Otsuka Pharmaceutical Co., Ltd. (2) · Shaddy, Robert, M.D. (2) · Advanz Pharma (1) · Amgen (1) · Aspirus Heart and Vascular Institute-Research and Education (1) · Assistance Publique - Hôpitaux de Paris (1) · Azienda USL Reggio Emilia - IRCCS (1) · Biogen (1) · Bristol-Myers Squibb (1) · CTI-1, LLC (1) · German Heart Institute (1)
United States (18) · Poland (7) · Argentina (6) · Brazil (6) · Canada (6) · France (6) · Germany (6) · Italy (6) · Sweden (6) · Belgium (5) · Czechia (5) · Romania (5) · Russia (5) · Australia (4) · Hungary (4)
Marc J Semigran, MD (2) · Barry A Borlaug, MD (1) · Barry Greenberg, MD (1) · Boris Nasseri, MD (1) · Carlo Menozzi, MD (1) · Chris Granger, MD (1) · Christof Stamm, MD (1) · Daniel Ter-Minassian, MD (1) · Dr Salim Yusuf (1) · Edimar A Bocchi, Prof. (1) · German Larrain, MD (1) · J. Randall Curtis, MD, MPH (1) · Joshua Hare, MD (1)
PMID 37366061, PMID 19196892, PMID 25326006, PMID 29431256, PMID 31370950, PMID 33301080, PMID 36632831, PMID 15152059, PMID 16230259, PMID 17384437, PMID 17384438, PMID 17848651, PMID 18279770, PMID 18549913, PMID 18992654, PMID 19001508, PMID 19204305, PMID 20142024, PMID 20231531, PMID 20435194, PMID 21068341, PMID 21123186, PMID 21199833, PMID 21292991, PMID 21350053, PMID 21606084, PMID 21693723, PMID 21715583, PMID 21750125, PMID 21805159, PMID 21875912, PMID 22064591, PMID 22093207, PMID 22267751, PMID 22651239, PMID 22887722, PMID 23351825, PMID 23478743, PMID 23487543, PMID 23743487, PMID 24302090, PMID 24497345, PMID 24626998, PMID 24649963, PMID 24737459, PMID 24864045, PMID 24874200, PMID 25225241, PMID 25319879, PMID 26067854
2009 (1), R01HL126638 (1), R01HL128526 (1), R01NR009987 (1), U01HL125205 (1), U10HL110262 (1)