14 completed, 10 unknown, 7 recruiting, 4 withdrawn. 18 Not applicable, 5 Phase 2, 4 Phase 1, 2 Phase 4, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| REPAIR Sleep Study REPAIR Sleep, Healthy Living - Cognition Disorder, Alzheimer Disease | Not applicable | Not yet recruiting | Emory University | 120 | 2026-07-01 | 2026-05-07 |
| MEOP - Multidimensional Evaluations in Oncological Psychiatry Psychiatric and neuropsychological evaluation through rating scales - Psychiatric Disorder, Cognition Disorder | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 2000 | 2026-01-30 | 2026-02-12 | |
| Nutrition-based Interventions to Prevent Cognitive Decline Nutrition-related lifestyle group sessions, Cognitive training, Clinical nutrition consultations - Cognitive Dysfunction, Cognition Disorder | Not applicable | Recruiting | Instituto de Saude Publica da Universidade do Porto | 120 | 2025-01-27 | 2025-12-05 |
| The Trajectory and Influencing Factors of Cognitive Level in ICU Delirium Patients After Transfer Out of the ICU Cognition Disorder, ICU | Unknown | Zunyi Medical College | 240 | 2024-09-30 | 2024-12-16 | |
| DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients Emergency Psychiatric, Cognition Disorder | Active not recruiting | Ohio State University | 1000 | 2024-07-01 | 2025-08-11 | |
| Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery Depth of anesthesia titration using pEEG - Delirium, Postoperative, Anesthesia | Not applicable | Recruiting | Auckland City Hospital | 2766 | 2024-05-20 | 2025-09-25 |
| Portable Mixed Reality-based Platform for Assessment of Progress in Multisensory Rehabilitation Strategies Post-TBI Praxis, Supervised cardiovascular exercise - Brain Concussion, Vestibular Disorder | Not applicable | Unknown | BlueHalo | 30 | 2024-02-12 | 2024-03-18 |
| Polyamine Treatment in Elderly Patients With Coronary Artery Disease Spermidine, Placebo - Ischemic Heart Disease, Myocardial Infarction | Phase 2 | Completed | University of Aarhus | 187 | 2024-01-01 | 2026-07-01 |
| Computerized Training of Attention and Working Memory in Post COVID-19 Patients With Cognitive Complaints RehaCom - COVID-19, Cognitive Impairment | Not applicable | Unknown | Erasmus Medical Center | 50 | 2023-12-01 | 2024-03-13 |
| The Role of EEG in Identifying Cognitive Changes in Parkinson's Disease tDCS + tredmill training (Standart trehab training), Cognitite-motor Dual Task Training (DT training) - Parkinson Disease, Cognition Disorder | Not applicable | Unknown | Federal University of Paraíba | 36 | 2023-08-02 | 2023-12-01 |
| Systemic Lupus Erythematosus Exercise - System; Lupus Erythematosus, Cognition Disorder | Not applicable | Unknown | Biruni University | 30 | 2023-08-02 | 2023-10-18 |
| Inflammatory Markers and Level of Cortical Hyperactivity General anesthesia - Cognition Disorder | Completed | University of Chile | 20 | 2023-08-01 | 2025-11-20 | |
| A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China Structured Multi-domain Intervention, Self-Guided Intervention - Cognitive Impairment, Alzheimer Disease | Not applicable | Recruiting | Zhejiang University | 1200 | 2023-05-28 | 2023-06-06 |
| Interventions in Mathematics and Cognitive Skills Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator - Math Learning Disability, Child Development | Not applicable | Recruiting | Stanford University | 180 | 2023-05-05 | 2026-08-11 |
| The Impact TDCS-linked Motor and Cognitive Training Gains in Parkinson's Disease Cognitive training - Parkinson Disease, Cognition Disorder | Not applicable | Active not recruiting | Federal University of Paraíba | 242 | 2022-10-03 | 2025-01-17 |
| The Effects of Cognitive Rehabilitation on Motor Performance, Balance and Fear of Falling in Stroke Patients Cognitive Rehabilitation, Conventional Therapy - Stroke, Cognition Disorder | Not applicable | Unknown | Istanbul University - Cerrahpasa | 24 | 2022-09-01 | 2022-08-05 |
| The Impact of Aripiprazole Long-acting on Myelin and Cognition in the Onset of Schizophrenia Aripiprazole - Schizophrenia, Myelin Degeneration | Phase 4 | Completed | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 15 | 2022-08-01 | 2024-12-27 |
| Cognitive Exercises in Survivors of a Prolonged ICU Stay. Cognitive exercises - Critical Illness, Cognition Disorder | Not applicable | Active not recruiting | University of Liege | 130 | 2021-10-01 | 2023-06-27 |
| Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of ACD856 ACD856, Placebo - Alzheimer Disease, Cognition Disorder | Phase 1 | Completed | AlzeCure Pharma | 24 | 2021-09-29 | 2022-07-20 |
| The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study Structured Lifestyle Intervention, Self-Guided Intervention - Cognitive Impairment, Alzheimer Disease | Not applicable | Completed | National University of Singapore | 1212 | 2021-08-23 | 2026-08-10 |
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Cognition Disorders (40) · Cognitive Dysfunction (11) · Alzheimer Disease (8) · Mental Disorders (6) · Neurocognitive Disorders (6) · Brain Diseases (4) · Dementia (4) · Memory Disorders (4) · Nervous System Diseases (4) · Stroke (4) · Brain Injuries, Traumatic (3) · Delirium (3) · Attention Deficit Disorder with Hyperactivity (2) · Behavior (2) · Central Nervous System Diseases (2)
Mental Disorders (34) · Neurocognitive Disorders (34) · Nervous System Diseases (23) · Central Nervous System Diseases (19) · Brain Diseases (17) · Pathological Conditions, Signs and Symptoms (15) · Neurodegenerative Diseases (11) · Signs and Symptoms (11) · Neurologic Manifestations (10) · Neurobehavioral Manifestations (8) · Tauopathies (8) · Dementia (7) · Cardiovascular Diseases (5) · Neurodevelopmental Disorders (5) · Vascular Diseases (5)
Cognitive Training (4) · Exercise (2) · Anesthesia, General (1) · Aripiprazole (1) · Aspirin (1) · Cardiopulmonary Bypass (1) · Cardiovascular Surgical Procedures (1) · Clopidogrel (1) · Correction of Hearing Impairment (1) · Dexmedetomidine (1) · Donepezil (1) · Galantamine (1) · Hematologic Tests (1) · Immersion (1) · Mental Status and Dementia Tests (1)
AlzeCure Pharma (3) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Federal University of Paraíba (2) · Instituto de Saude Publica da Universidade do Porto (2) · Auckland City Hospital (1) · Augusta University (1) · Biruni University (1) · BlueHalo (1) · Centre Hospitalier Universitaire, Amiens (1) · Centre d'Investigation Clinique et Technologique 805 (1) · Duke University (1) · Emory University (1) · Erasmus Medical Center (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1)
United States (12) · France (3) · Sweden (3) · Brazil (2) · China (2) · Portugal (2) · Belgium (1) · Canada (1) · Chile (1) · Denmark (1) · Germany (1) · Italy (1) · Netherlands (1) · New Zealand (1) · Russia (1)
Johan Sandin (2) · Amir Gandjbakhche, Ph.D. (1) · Antonello Penna, MD, PhD (1) · Carol Smith, RN (1) · Carolyn Deng (1) · Christopher A. Walsh, M.D., Ph.D. (1) · Christopher LH Chen, MD (1) · David Hasan, MD (1) · Eric M Wassermann, M.D. (1) · Gerard Ribbers, Professor (1)
PMID 38353689, PMID 33849856, PMID 34276344, PMID 35935417, PMID 38706276, PMID 40470496, PMID 40483726, PMID 40533218, PMID 40541266, PMID 40670782, PMID 40803734, PMID 41168834, PMID 41943481, PMID 42000692
K01AA026005 (1), R01AG093890 (1), R01HD059205 (1)