3 completed, 3 unknown, 2 terminated, 2 withdrawn. 11 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 3, Unknown 3, Terminated 2, Withdrawn 2, Not yet recruiting 1 |
| Phase 1 | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Coagulopathy: new trials by email Literature Review of Coagulopathy trials Research Report on Coagulopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| The Utility of Camostat Mesylate in Patients With COVID-19 Associated Coagulopathy (CAC) and Cardiovascular Complications Camostat Mesylate, Microcrystalline Cellulose, NF - Coagulopathy, Cardiovascular Complication | Phase 1 / Phase 2 | Withdrawn | Yale University | 2021-11-01 | 2022-05-18 | |
| The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations Aspirin 81 mg, Vitamin D - COVID, Vitamin D Deficiency | Phase 2 | Withdrawn | Louisiana State University Health Sciences Center in New Orleans | 2020-05-01 | 2021-12-27 | |
| REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic Coagulopathy Prothrombin Complex Concentrate, Whole Blood, Plasma, Packed Red Blood Cells - Coagulopathy, Hemorrhage | Phase 2 | Unknown | Bellal A. Joseph, MD, FACS | 280 | 2020-01-01 | 2019-06-10 |
| Comparison of the Efficacy & Safety of Resusix With FP24 in Patients With Acquired Coagulopathy Resusix, FP24 (Frozen Plasma) - Coagulopathy | Phase 2 | Terminated | Entegrion, Inc. | 4 | 2018-12-14 | 2021-01-07 |
| Fibrinogen Early In Severe Trauma studY Junior Fibrinogen Concentrate, Cryoprecipitate - Trauma, Hemorrhage | Phase 2 | Unknown | Gold Coast Hospital and Health Service | 44 | 2018-07-01 | 2020-06-29 |
| Fibrinogen Early In Severe Trauma studY Fibrinogen Concentrate, Cryoprecipitate - Trauma, Haemorrhage | Phase 2 | Completed | Gold Coast Hospital and Health Service | 100 | 2016-12-01 | 2018-03-05 |
| Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy VHA algorithm - Hemorrhage, Coagulopathy | Phase 2 | Completed | Queen Mary University of London | 412 | 2016-06-01 | 2018-08-29 |
| Fibrinogen in the Initial Resuscitation of Severe Trauma (FiiRST) Fibrinogen concentrate, Placebo Comparator - Trauma, Injury | Phase 1 / Phase 2 | Completed | Sunnybrook Health Sciences Centre | 50 | 2014-10-01 | 2016-04-14 |
| Safety and Efficacy Study Comparing Pad-gauze With Anti-fibrinolytic Agent Hemostopan™) to a Regular Pad-gauze pad-gauze with tranexamic acid (Hemostopan™) - Bleeding, Coagulopathy | Phase 2 / Phase 3 | Unknown | Sion Microtec Ltd. | 25 | 2013-10-01 | 2015-02-13 |
| Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma Vitamin C, Vitamin E, Saline (for Vitamin C) - Coagulopathy, Nosocomial Pneumonia | Phase 2 | Terminated | University of Alabama at Birmingham | 11 | 2013-05-01 | 2017-03-29 |
Hemostatic Disorders (11) · Hemorrhage (6) · Wounds and Injuries (4) · Afibrinogenemia (1) · COVID-19 (1) · Disseminated Intravascular Coagulation (1) · Healthcare-Associated Pneumonia (1) · Shock, Septic (1) · Vitamin D Deficiency (1)
Cardiovascular Diseases (11) · Hematologic Diseases (11) · Hemic and Lymphatic Diseases (11) · Hemorrhagic Disorders (11) · Vascular Diseases (11) · Pathologic Processes (8) · Pathological Conditions, Signs and Symptoms (8) · Infections (3) · Blood Coagulation Disorders (2) · Lung Diseases (2) · Pneumonia (2) · Respiratory Tract Diseases (2) · Respiratory Tract Infections (2) · Avitaminosis (1) · Blood Coagulation Disorders, Inherited (1)
Fibrinogen (3) · cryoprecipitate coagulum (2) · Ascorbic Acid (1) · Aspirin (1) · Factor IX (1) · Saline Solution (1) · Sodium Chloride (1) · Vitamin D (1) · Vitamin E (1) · alpha-Tocopherol (1) · camostat (1) · microcrystalline cellulose (1)
Gold Coast Hospital and Health Service (2) · Bellal A. Joseph, MD, FACS (1) · Entegrion, Inc. (1) · Louisiana State University Health Sciences Center in New Orleans (1) · Queen Mary University of London (1) · Sion Microtec Ltd. (1) · Sunnybrook Health Sciences Centre (1) · University Hospital, Strasbourg, France (1) · University of Alabama at Birmingham (1) · Yale University (1)
Australia (2) · United States (2) · Canada (1) · Denmark (1) · France (1) · Germany (1) · Israel (1) · Netherlands (1) · Norway (1) · United Kingdom (1)
Arya Mani, MD (1) · Barto Nascimento, MD MSc (1) · Bellal Joseph, MD (1) · Christine Gaarder, MD (1) · Frank H Lau, MD (1) · James Winearls, MBBS (1) · Jean-Francois Pittet, M.D. (1) · Jeffrey Kerby, M.D., Ph.D. (1) · Karim Brohi, FCRS FRCA (1) · Michael Galiger (1) · Mudi Misgav, MD (1) · Shane George, MBBS (1)
PMID 28549445, PMID 29047413, PMID 35508351, PMID 36163263, PMID 37489818