Blood Coagulation Disorders, Inherited: Clinical Trials

662 completed, 125 unknown, 115 recruiting, 88 terminated. 236 Phase 3, 152 Phase 1, 149 Phase 2, 148 Not applicable, 86 Phase 4.

By phase and status

Phase	Trials	Status
Phase 3	236	Completed 158, Recruiting 21, Terminated 19, Active not recruiting 17, Unknown 8, Withdrawn 7, Not yet recruiting 6
Phase 1	152	Completed 100, Terminated 19, Recruiting 15, Active not recruiting 7, Unknown 5, Not yet recruiting 3, Withdrawn 2, Enrolling by invitation 1
Phase 2	149	Completed 74, Terminated 30, Recruiting 18, Unknown 10, Active not recruiting 9, Not yet recruiting 5, Withdrawn 2, Enrolling by invitation 1
Not applicable	148	Completed 79, Unknown 28, Terminated 12, Recruiting 10, Not yet recruiting 9, Enrolling by invitation 4, Withdrawn 4, Active not recruiting 2
Phase 4	86	Completed 51, Terminated 10, Recruiting 9, Unknown 8, Withdrawn 5, Active not recruiting 3
Early Phase 1	6	Completed 2, Recruiting 2, Unknown 1, Withdrawn 1

Follow Blood Coagulation Disorders, Inherited: new trials by email Literature Review of Blood Coagulation Disorders, Inherited trials Research Report on Blood Coagulation Disorders, Inherited

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Lentiviral FIX Gene Therapy YUVA-GT-F901 - Hemophilia B	Phase 1	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	10	2027-06-01	2026-08-26
Lentiviral FVIII Gene Therapy YUVA-GT-F801 - Hemophilia A	Phase 1	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	10	2027-06-01	2026-09-01
Post Approval Phase 4 Study to Learn More About How Safe Octocog Alfa is, and How Well it Works in Patients With Severe Hemophilia A in India Octocog alfa - Severe Hemophilia A		Not yet recruiting	Bayer	30	2027-04-05	2026-10-21
Multicomponent Pain Self-Management in Adults With Haemophilic Arthropathy Multicomponent pain self-management programme - Hemophilic Arthropathy, Chronic Pain	Not applicable	Not yet recruiting	Investigación en Hemofilia y Fisioterapia	70	2027-03-01	2026-10-06
Ultrasound Assessment of Joint Health in Patients With Mild Hemophilia (Factor Levels 5-40%) Joint Ultrasound (HEAD-US), Blood Sample for Coagulation Factor Measurement - Mild Hemophilia	Not applicable	Not yet recruiting	Assistance Publique - Hôpitaux de Paris	150	2027-02-01	2026-08-17
Efanesoctocog Prophylaxis Or The Optimization Of Treatment: Real-World Experience Of Taylorizing Clotting Therapy In Hemophilia A Study questionnaires, Clinical/pharmacological data collection - Hemophilia A Patient		Not yet recruiting	Nantes University Hospital	553	2027-01-01	2026-09-25
Study of Efficacy and Safety of FRSW107 in Pediatric Patients With Severe Hemophilia A FRSW107 - Severe Hemophilia A	Phase 3	Not yet recruiting	Hangzhou Gensciences Biopharmaceutical Co., Ltd.	76	2026-12-25	2024-06-20
CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID)	Phase 2	Not yet recruiting	Charite University, Berlin, Germany	38	2026-12-01	2026-07-24
Clinical Trial of NXT007 for the Prophylactic Treatment of Hemophilia A in Infants and Children NXT007 - Hemophilia A	Phase 3	Not yet recruiting	Hoffmann-La Roche	50	2026-11-30	2026-10-19
A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A Denecimig - Haemophilia A	Phase 3	Not yet recruiting	Novo Nordisk A/S	84	2026-10-09	2026-09-21
A Study to Learn About the Study Medicine (Called Marstacimab) in People With Hemophilia A or B Marstacimab - Hemophilia		Not yet recruiting	Pfizer	100	2026-10-05	2026-10-05
Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE) Aripiprazole (low-dose, 1mg), Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID-19 Condition (PCC or Long COVID)	Phase 2	Not yet recruiting	Christiana Franke	138	2026-10-01	2026-07-20
A Study of Elranatamab for Inhibitor Eradication in Patients With Hemophilia A Elranatamab - Hemophilia A With Inhibitors	Not applicable	Not yet recruiting	Institute of Hematology & Blood Diseases Hospital, China	20	2026-10-01	2026-08-26
Liver Biopsy Following Gene Therapy For Hemophilia Liver Biopsy - Hemophilia A, Hemophilia B		Not yet recruiting	St. Jude Children's Research Hospital	8	2026-10-01	2026-09-17
A Phase 2 Study of Foscenvivint in Liver Cirrhosis Patients Caused by HIV/HCV Co-infection With Hemophilia Foscenvivint - Liver Cirrhosis	Phase 2	Recruiting	Kiminori Kimura, MD	7	2026-10-01	2026-10-05
A Phase III Clinical Trial Evaluating SR604 Injection for Prophylactic Treatment in Patients With Hemophilia SR604 - Hemophilia A, Hemophilia A and B	Phase 3	Not yet recruiting	Shanghai RAAS Blood Products Co., Ltd.	90	2026-09-30	2026-10-15
Study of a Smart Sharps Disposal Device in Patients With Hemophilia The smart Sharps device is given to the patient and they use it to throw needles away in. It is not internal to the patient. - Hemophilia A and B	Not applicable	Not yet recruiting	University of Pennsylvania	23	2026-09-30	2026-07-09
Patient Preferences in Treatment of Haemophilia A With and Without Inhibitors: a Discrete Choice Experiment in Germany No treatment given - Haemophilia A		Enrolling by invitation	Novo Nordisk A/S	150	2026-09-25	2026-10-06
A Prospective Assessment of Bone Health in Patients With Severe Hemophilia A on Factor VIII vs Factor Mimetic Prophylaxis (Efa Emi Bone Health Study) Hemophilia a		Recruiting	Arkansas Children's Hospital Research Institute	50	2026-09-21	2026-10-05
Cryo-FIRST: Effectiveness of INTERCEPT Fibrinogen Complex (IFC) for Trauma-Associated Hemorrhage Pathogen Reduced Cryoprecipitated Fibrinogen Complex - Hypofibrinogenemia, Hemorrhage		Enrolling by invitation	Cerus Corporation	320	2026-09-15	2026-10-14

Showing 20 of 1126. Sign in to see all of them.

Narrower conditions

Hemophilia A (787)  ·  Hemophilia B (260)  ·  von Willebrand Diseases (95)  ·  Blood Coagulation Disorders (43)  ·  Hemostatic Disorders (43)  ·  Hematologic Diseases (42)  ·  Wiskott-Aldrich Syndrome (41)  ·  Hemorrhage (33)  ·  Joint Diseases (30)  ·  Coagulation Protein Disorders (29)  ·  Genetic Diseases, Inborn (26)  ·  Afibrinogenemia (25)  ·  Hemorrhagic Disorders (25)  ·  Motor Activity (19)

Broader conditions

Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1126)  ·  Hemic and Lymphatic Diseases (1126)  ·  Genetic Diseases, Inborn (1100)  ·  Hematologic Diseases (1084)  ·  Hemorrhagic Disorders (1082)  ·  Blood Coagulation Disorders (1081)  ·  Coagulation Protein Disorders (1017)  ·  Genetic Diseases, X-Linked (297)  ·  Pathological Conditions, Signs and Symptoms (148)  ·  Blood Platelet Disorders (128)  ·  Pathologic Processes (113)  ·  Musculoskeletal Diseases (77)  ·  Cardiovascular Diseases (76)  ·  Vascular Diseases (69)

Interventions

Factor VIII (136)  ·  F8 protein, human (56)  ·  emicizumab (34)  ·  Factor IX (33)  ·  BAY 14-2222 (22)  ·  von Willebrand Factor (20)  ·  factor VIII-Fc fusion protein (19)  ·  recombinant factor VIII N8 (19)  ·  BAX 855 (18)  ·  Blood Specimen Collection (16)  ·  Injections (16)  ·  recombinant FVIIa (16)  ·  recombinant factor VIII SQ (14)  ·  BIVV001 (11)  ·  Fibrinogen (11)

Sponsors

Novo Nordisk A/S (84)  ·  Baxalta now part of Shire (59)  ·  Bayer (57)  ·  Pfizer (44)  ·  CSL Behring (40)  ·  Octapharma (24)  ·  Wyeth is now a wholly owned subsidiary of Pfizer (21)  ·  Investigación en Hemofilia y Fisioterapia (20)  ·  Hoffmann-La Roche (19)  ·  Bio Products Laboratory (18)  ·  Swedish Orphan Biovitrum (16)  ·  Takeda (16)  ·  Institute of Hematology & Blood Diseases Hospital, China (15)  ·  Hospices Civils de Lyon (13)  ·  Bioverativ Therapeutics Inc. (11)

Countries

United States (427)  ·  United Kingdom (211)  ·  Spain (205)  ·  France (204)  ·  Germany (191)  ·  Italy (190)  ·  Canada (132)  ·  Turkey (Türkiye) (110)  ·  China (109)  ·  Japan (98)  ·  Netherlands (94)  ·  Poland (94)  ·  Austria (90)  ·  Sweden (80)  ·  Australia (79)

Top investigators

Lei Zhang, MD (11)  ·  Renchi Yang, PhD (6)

Results publications

PMID 40750723, PMID 26196195, PMID 40386832, PMID 42698050, PMID 19216617, PMID 35939785, PMID 36408876, PMID 25495795, PMID 26931631, PMID 31697801, PMID 33719084, PMID 35075289, PMID 36848635, PMID 39091324, PMID 17687129, PMID 17880439, PMID 22149959, PMID 22212248, PMID 22765835, PMID 24335249, PMID 25273984, PMID 26157075, PMID 26679394, PMID 27002680, PMID 28691557, PMID 29224506, PMID 29445374, PMID 30157389, PMID 30369044, PMID 32293786, PMID 32744769, PMID 32915950, PMID 33269010, PMID 34788507, PMID 34922648, PMID 35857660, PMID 35879931, PMID 36796484, PMID 36818468, PMID 36884286, PMID 37341915, PMID 38237075, PMID 38446574, PMID 39341368, PMID 39642315, PMID 40099428, PMID 40188458, PMID 40197980, PMID 40347119, PMID 40986187

NIH funding

2016 (19), 2023 (19), 2009 (18), 2015 (13), 2017 (13), 2008 (12), 2014 (11), 2018 (11), 2025 (5), 2005 (4), 2019 (4), 1UG3HL165064-01 (1), 2004 (1), K23HL105785 (1), P30CA015704 (1)