42 completed, 6 terminated, 4 unknown, 3 withdrawn. 23 Phase 3, 17 Phase 2, 12 Not applicable, 4 Phase 1, 4 Phase 4.
Follow alpha-Tocopherol: new trials by email Literature Review of alpha-Tocopherol trials Research Report on alpha-Tocopherol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity Ascorbic acid (Vitamin C), tocopherol alpha, Ascorbic acid + tocopherol alpha - Obesity (BMI>30), Neuroinflammation | Not applicable | Not yet recruiting | Autonomous University of Morelos | 192 | 2026-08-10 | 2026-08-24 |
| Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation Pentoxifylline, Placebo, α-Tocopherol - Non-Small Cell Lung Cancer, Radiation Induced Lung Injury (RILI) | Phase 2 | Recruiting | University Health Network, Toronto | 150 | 2026-06-15 | 2026-08-06 |
| Vitamin E Plus Mefenamic Acid Versus Mefenamic Acid Alone for Treating Primary Dysmenorrhea in Women Mefenamic acid, Vitamin E capsule - Dysmenorrhea Primary, Vitamin E | Phase 4 | Completed | Nishtar Medical University | 60 | 2025-07-15 | 2026-03-12 |
| Medicine-induced Cardiac Hemodialysis on COVID-19 Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility - Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis | Phase 4 | Completed | Yang I. Pachankis | 1 | 2023-01-02 | 2023-02-03 |
| Vitamin E Efficacy in HI/HA Vitamin E - Hyperinsulinism-Hyperammonemia Syndrome | Phase 2 | Withdrawn | Children's Hospital of Philadelphia | 2022-11-01 | 2022-12-13 | |
| Vitamin E Dosing Study Vitamin E, Placebo - Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 200 | 2022-08-05 | 2026-05-14 |
| Effect of Alpha Tocopherol and Psyllium on Lipid Levels in Dyslipidaemia Patients Alpha tocopherol, Combination therapy (Alpha Tocopherol and Psyllium husk), Placebo Control - Dyslipidaemia | Phase 2 | Completed | NUR International University | 60 | 2022-06-15 | 2026-05-27 |
| Effect of Parenteral Alpha-Tocopherol in the Definitive Surgery of Tetralogy of Fallot alpha-Tocopherol, Sterile Water for Injection - Tetralogy of Fallot (TOF), Alpha-tocopherol | Early Phase 1 | Completed | Dr Cipto Mangunkusumo General Hospital | 60 | 2022-05-01 | 2025-09-26 |
| Evaluation of Lacrimal Punctal Changes by Anterior Segment Optical Coherence Tomography AS-OCT After Topical Combined Antibiotics and Steroids Treatment in Cases of Inflammatory Punctual Stenosis 5 mg chloramphenicol, 1 mg dexamethasone sodium phosphate, 0.25 mg tetryzoline hydrochloride, 2 mg Hydroxypropyl Methyl Cellulose, 10 mg α-tocopherol acetate and 8 mg macrogol 400)., sodium hyaluronate, polyethylene and propylene glycol based) three times daily for three months - Ophthalmopathy , Lacrimal System | Phase 4 | Completed | Sohag University | 64 | 2020-11-15 | 2021-09-13 |
| Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) Patients Vitamin E, Ursodeoxycholic acid, Pentoxifylline - Nonalcoholic Steatohepatitis (NASH) | Phase 4 | Completed | Kafrelsheikh University | 102 | 2020-02-01 | 2021-07-27 |
| Apoptosis Proteins and Endothelial Dysfunction in Patients With Atherosclerosis of Peripheral Arteries Bypass surgery, Endovascular angioplasty/stenting, Hybrid surgery - Atherosclerosis, Endothelial Dysfunction | Completed | Ryazan State Medical University | 250 | 2020-01-01 | 2023-11-18 | |
| Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer Atorvastatin, Pentoxifylline, Vitamin E Compound - Male Erectile Disorder, Prostate Adenocarcinoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 14 | 2019-11-20 | 2023-10-17 |
| PentoxIfylline and Tocopherol for the Treatment of Post-radiotherapy Fibrosis in Head and Neck Cancer Patients Arm B: A combination of pentoxifylline and tocopherol acetate in addition to best standard care [a structured programme of rehabilitation exercises] for 6 months, • Arm A: Best standard of care only [a structured programme of rehabilitation exercises] for 6 months - Head and Neck Fibrosis | Phase 1 | Completed | University College, London | 50 | 2019-09-01 | 2026-03-03 |
| The Efficacy, Safety and Tolerability of Oral LPCN 1144 in Subjects With Nonalcoholic Steatohepatitis LPCN 1144 Formulation A, LPCN 1144 Formulation B, Placebo - Nonalcoholic Steatohepatitis (NASH) | Phase 2 | Completed | Lipocine Inc. | 56 | 2019-08-27 | 2023-12-14 |
| Effectiveness of Vitamin E and Hydrogen-Rich Water on Radiation Therapy-Induced Adverse In Patients With Rectal Cancer Vitamin E, Hydrogen rich water, placebo - Radiation-induced Injuries in Patients With Rectal Cancer | Phase 3 | Unknown | University of Jordan | 60 | 2019-07-06 | 2021-02-17 |
| Meat-based Versus Pesco-vegetarian Diet and Colorectal Cancer Meat-based diet, Meat-based diet supplemented with alpha-tocopherol (MBD-T), Pesco-vegetarian diet - Nutrition Aspect of Cancer, Diet Modification | Not applicable | Completed | Azienda Ospedaliero-Universitaria Careggi | 103 | 2019-06-01 | 2021-07-30 |
| Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome Vitamin E - Hyperinsulinism-Hyperammonemia Syndrome | Not applicable | Completed | Elizabeth A Rosenfeld | 14 | 2019-04-15 | 2022-11-25 |
| Clinical Benefit of Spa Care on Severe Radiation-induced Fibrosis After Postoperative Radiotherapy for Breast Cancer skin-oriented spa care, Pentoxifylline, Tocopherol acetate - Breast Carcinoma, Fibrosis | Phase 3 | Unknown | Institut de Cancérologie de Lorraine | 142 | 2018-12-01 | 2018-08-08 |
| Effect of Nutrition Ingredients on Microbiota Modulation Vitamin B2, Vitamin C, Vitamin B2 + C - Healthy Volunteers | Not applicable | Completed | dsm-firmenich Switzerland AG | 96 | 2018-08-20 | 2020-03-30 |
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Non-alcoholic Fatty Liver Disease (6) · Obesity (4) · Prostatic Neoplasms (4) · Alzheimer Disease (2) · Anxiety Disorders (2) · Atherosclerosis (2) · Breast Neoplasms (2) · Burns (2) · Carcinoma, Non-Small-Cell Lung (2) · Colonic Neoplasms (2) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Fatty Liver (2) · Fibrosis (2) · Hemolysis (2)
SWOG Cancer Research Network (3) · University Health Network, Toronto (3) · Bambino Gesù Hospital and Research Institute (2) · M.D. Anderson Cancer Center (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Yolanda de Diego Otero (2) · Abbott Nutrition (1) · Assistance Publique - Hôpitaux de Paris (1) · Autonomous University of Morelos (1) · Azienda Ospedaliero-Universitaria Careggi (1) · Bagcilar Training and Research Hospital (1) · Children's Hospital of Philadelphia (1) · Dr Cipto Mangunkusumo General Hospital (1) · Elizabeth A Rosenfeld (1) · Helse Stavanger HF (1)
United States (22) · Canada (4) · France (3) · Italy (3) · Egypt (2) · Indonesia (2) · Ireland (2) · Pakistan (2) · Spain (2) · Thailand (2) · China (1) · Greece (1) · Iran (1) · Israel (1) · Mexico (1)
Linda E Sousse, PhD, MBA (2) · Wilfred Levin, MD (2) · Adis Tasanarong, MD (1) · Alessandro Casini, MD (1) · Andrew Levy, MD PhD (1) · Anthony DelConte (1) · Arun Sanyal, MD (1) · Athanasios Z Jamurtas, Dr (1) · Brody Holohan, PhD (1) · Celeste C Finnerty, Ph.D. (1) · Chad Tang (1) · Chi P Lin, MD (1) · Christina Sherry, PhD, RD (1) · Daniel D Karp, M.D. (1) · Daniel L Traber, PhD (1)
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