20 completed, 6 recruiting, 3 active not recruiting, 2 not yet recruiting. 23 Not applicable, 1 Early Phase 1, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 23 | Completed 16, Recruiting 4, Active not recruiting 2, Withdrawn 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Circadian Dysregulation: new trials by email Literature Review of Circadian Dysregulation trials Research Report on Circadian Dysregulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit Sleep chronobundle, Control - Sleep, Circadian Dysregulation | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-11-30 | 2026-10-21 |
| Body Clocks - Coordination of Peripheral and Central Oscillators Circadian Dysregulation | Recruiting | Stanford University | 20 | 2026-04-15 | 2026-08-12 | |
| Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU) Light Therapy - Circadian Dysregulation, Light Exposure | Not applicable | Recruiting | Laura Beth Kalvas | 30 | 2026-03-26 | 2026-05-22 |
| Nighttime Synchrony of Your Nutrition and Circadian Health Central Clock Misalignment, Peripheral Misalignment - Sleep, Metabolism Changes | Not applicable | Recruiting | University of Utah | 120 | 2025-12-19 | 2026-01-22 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Circadian Health Regulation and Optimization for Rejuvenation Outcomes Circadian Rhythm Optimization - Aging, Healthy, Blood Sugar; High | Not applicable | Active not recruiting | Salk Institute for Biological Studies | 16 | 2025-10-22 | 2025-12-31 |
| The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation. Naturalistic Light Intervention - Post Stroke Depression, Post Stroke Fatigue | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 45 | 2025-04-10 | 2025-04-15 |
| NIA_Improving Function and Well-being by Improving Patient Memory: Transdiagnostic Sleep and Circadian Treatment Memory Support Intervention, Transdiagnostic Intervention for Sleep and Circadian Dysfunction - Sleep Disorder, Circadian Dysregulation | Not applicable | Recruiting | University of California, Berkeley | 178 | 2024-01-04 | 2025-11-24 |
| Compromised Sleep and Circadian Health After Critical Illness: From Diagnosis to Prediction (CHRONOCRIT) Circadian Dysregulation, Sleep Fragmentation | Unknown | Institut de Recerca Biomèdica de Lleida | 271 | 2023-09-27 | 2023-09-28 | |
| Maintaining Behavior Change: An Evaluation of a Habit-based Sleep Health Intervention Habit-based Sleep Health Intervention, Text messaging intervention - Circadian Dysregulation | Not applicable | Active not recruiting | University of California, Berkeley | 160 | 2022-05-04 | 2025-11-05 |
| Metabolic Effects of Natural Office Light in Type 2 Diabetes Natural or artificial office light exposure - Diabetes Mellitus, Type 2, Circadian Dysregulation | Not applicable | Completed | Maastricht University | 13 | 2022-03-16 | 2023-08-15 |
| Maintaining Behavior Change: A 6-year Follow-up of Adolescent 'Night-owls' Circadian Dysregulation | Completed | University of California, Berkeley | 108 | 2021-12-01 | 2022-10-07 | |
| Mini-treatment Experiments to Clarify How to Assist People to Habit Formation RISE-UP Routine, Awareness Training, Vigilant Monitoring - Sleep Disorder, Circadian Dysregulation | Not applicable | Completed | University of California, Berkeley | 286 | 2021-10-07 | 2023-05-10 |
| Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 2: Train-the-Trainer Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Usual Care Delayed Treatment - Sleep Disorder, Circadian Dysregulation | Not applicable | Completed | University of California, Berkeley | 196 | 2020-12-14 | 2025-10-23 |
| Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans Oral sodium supplementation - Obesity, Hypertension | Not applicable | Completed | University of Alabama at Birmingham | 61 | 2020-11-14 | 2026-08-20 |
| Personalized Integrated Chronotherapy for Perinatal Depression Personalized Integrated Chronotherapy - Depression, Postpartum Depression | Not applicable | Completed | Rhode Island Hospital | 120 | 2020-11-02 | 2025-12-09 |
| Improving Well-being by Improving Memory for Treatment for Sleep and Circadian Dysfunction Trans-C for sleep and circadian function + Memory Support - Sleep Disorder, Circadian Dysregulation | Not applicable | Completed | University of California, Berkeley | 28 | 2020-05-01 | 2021-09-29 |
| Implementing and Sustaining a Sleep Treatment to Improve Community Mental Part 1: Implementation Health Outcomes Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Usual Care Delayed Treatment - Sleep Disorder, Circadian Dysregulation | Not applicable | Completed | University of California, Berkeley | 489 | 2020-01-08 | 2025-10-27 |
| The Impact of Artificial Sunlight on Human Sleep and Circadian Rhythms Light - Sleep, Circadian Dysregulation | Not applicable | Completed | VA Palo Alto Health Care System | 10 | 2019-07-01 | 2021-03-30 |
| Impact of Blueberry Consumption on Gastrointestinal Health Blueberry powder, Placebo powder - Obesity, Circadian Dysregulation | Not applicable | Completed | University of Nebraska Lincoln | 28 | 2019-03-26 | 2023-03-22 |
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Chronobiology Disorders (34) · Sleep Wake Disorders (7) · Sleep Deprivation (6) · Obesity (4) · Sleep Hygiene (3) · Alzheimer Disease (2) · Delirium (2) · Dementia (2) · Depression (2) · Diabetes Mellitus (2) · Parasomnias (2) · Sleep Disorders, Circadian Rhythm (2) · Anxiety Disorders (1) · Behavior (1) · Bulimia (1)
Nervous System Diseases (34) · Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (22) · Mental Disorders (19) · Neurologic Manifestations (15) · Sleep Wake Disorders (9) · Nutritional and Metabolic Diseases (8) · Behavior (7) · Dyssomnias (7) · Neurocognitive Disorders (5) · Body Weight (4) · Brain Diseases (4) · Central Nervous System Diseases (4) · Glucose Metabolism Disorders (4) · Metabolic Diseases (4)
Sleep (5) · Ultraviolet Therapy (3) · ramelteon (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Chronotherapy (1) · Electroencephalography (1) · Magnetic Resonance Spectroscopy (1) · Phototherapy (1) · Prebiotics (1) · Propofol (1) · Zolpidem (1)
University of California, Berkeley (7) · Massachusetts General Hospital (2) · Northwestern University (2) · Brigham and Women's Hospital (1) · Chang Gung Memorial Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Institut de Recerca Biomèdica de Lleida (1) · Laura Beth Kalvas (1) · Maastricht University (1) · Nyree Penn (1) · Oregon Health and Science University (1) · Rhode Island Hospital (1) · Rush University Medical Center (1) · Salk Institute for Biological Studies (1) · Stanford University (1)
United States (28) · Canada (1) · Denmark (1) · Israel (1) · Netherlands (1) · Spain (1) · Taiwan (1)
Allison Harvey, PhD (6) · Kaloyan S Tanev, MD (2) · Adriano Targa Dias Santos, PhD (1) · Anders Sode West, MD, PhD (1) · Chao-Yung Wang, MD (1) · Christopher Depner, PhD (1) · Eve Van Cauter (1) · Frank A Scheer, PhD (1) · Garth R Swanson, MD (1) · Heather E Rasmussen, PhD (1) · Jamie M Zeitzer, PhD (1) · Jeanne M Link, PhD (1) · Kenneth Wright, PhD (1) · Kristen Knuston, PhD (1) · Kristen Knutson, PhD (1)
PMID 40799745, PMID 20483660, PMID 30981000, PMID 33189083, PMID 34861073, PMID 36745299, PMID 36927461, PMID 37398014, PMID 37524198, PMID 37550730, PMID 37648646, PMID 38729603, PMID 39249560, PMID 39363383, PMID 39563407, PMID 40634991, PMID 40709255, PMID 40839336, PMID 41171520, PMID 41318500
KL2TR002370 (1), R01HL140577 (1), R01HL144716 (1), R01MH120147 (1)