24 completed, 14 recruiting, 12 not yet recruiting, 4 active not recruiting. 43 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3.
Follow Chronic Musculoskeletal Pain: new trials by email Literature Review of Chronic Musculoskeletal Pain trials Research Report on Chronic Musculoskeletal Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PainTrain-AI Pilot: Feasibility, Usability (SUS) and Concept-Shift in Primary Care and a Specialized Setting PainTrain-AI Behavioral Training - Chronic Musculoskeletal Pain | Not applicable | Not yet recruiting | Francesc Valenzuela Pascual | 40 | 2027-01-01 | 2026-04-02 |
| Real-world Evidence of Cannabinoid for Observed Pain Relief Chronic Musculoskeletal Pain, Delayed Onset Muscle Soreness (DOMS) | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 60 | 2027-01-01 | 2026-07-30 | |
| vEAET-H for Chronic Pain Patients Using Medical Cannabis in Israel - A Feasibility Study Group-based virtual Emotional Awareness & Expression Therapy - Hebrew (vEAET-H) - Chronic Musculoskeletal Pain, Cannabis Use | Not applicable | Recruiting | Reuth Rehabilitation Hospital | 42 | 2026-10-01 | 2026-07-28 |
| Massage, Sleep , and Pain Semi-Standardized Integrative Therapeutic Massage, Usual Care - Chronic Musculoskeletal Pain, Sleep Disturbances | Not applicable | Not yet recruiting | Defense and Veterans Center for Integrative Pain Management | 120 | 2026-10-01 | 2026-08-24 |
| Post-traumatic Estradiol Administration and Care Evaluation (PEACE) 17β-estradiol, Placebo - Chronic Musculoskeletal Pain, Sexual Assault | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-09-28 | 2026-10-09 |
| Multimodal Physiotherapy and Pain Coping in Primary Care Multimodal Physiotherapy Program Based on Pain Neuroscience Education and Therapeutic Exercise - Chronic Musculoskeletal Pain | Not applicable | Not yet recruiting | Universitat Jaume I | 68 | 2026-09-01 | 2025-12-23 |
| Feasibility, Acceptability And Usability Of The InControl Web Platform - A Rando Mized Parallel-Group Pilot Study of Mixed-methods InControl intervention, Usual Care - Chronic Musculoskeletal Pain | Not applicable | Not yet recruiting | Aveiro University | 34 | 2026-09-01 | 2026-08-19 |
| Illness Perception and Treatment Expectations in Lateral Elbow Pain Lateral Elbow Pain, Lateral Epicondylitis | Not yet recruiting | Acibadem University | 137 | 2026-07-31 | 2026-07-23 | |
| Correlation Between Diagnostic Nerve Block Response and Cryoneurolysis Outcome in Chronic Musculoskeletal Disorders cryoablation - Chronic Musculoskeletal Pain, Cryo Analgesia | Not applicable | Not yet recruiting | Universitair Ziekenhuis Brussel | 50 | 2026-07-01 | 2026-04-27 |
| Functional and Occupational Rehabilitation of Troops Chronic Musculoskeletal Pain | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 480 | 2026-06-01 | 2026-01-20 | |
| Multimodal Intervention for Persistent Musculoskeletal Pain in Primary Care Multimodal Pain Management Program, Usual Primary Care - Chronic Musculoskeletal Pain | Not applicable | Not yet recruiting | Universitat Jaume I | 146 | 2026-06-01 | 2026-03-10 |
| Non-invasive Vagus Nerve Stimulation for Chronic Musculoskeletal Pain Active Vagus Nerve Stimulation, Subtherapeutic Stimulation (Sham Control) - Chronic Musculoskeletal Pain, Autonomic Dysfunction | Not applicable | Not yet recruiting | University of Leeds | 12 | 2026-05-14 | 2026-05-11 |
| Pain Science Education and Therapeutic Exercise in Adults With Musculoskeletal Pain Pain Neuroscience Education (PNE) + Therapeutic Exercise, Therapeutic Exercise - Chronic Musculoskeletal Pain | Not applicable | Completed | University of Vigo | 38 | 2026-05-01 | 2026-08-26 |
| Network Modeling in Knee Osteoarthritis Chronic Musculoskeletal Pain | Enrolling by invitation | George Mason University | 200 | 2026-03-13 | 2026-08-05 | |
| Neural Mobilization to Improve Chronic Musculoskeletal Pain in Older Adults Active Neural Mobilization Exercises - Chronic Musculoskeletal Pain | Not applicable | Active not recruiting | Aveiro University | 4 | 2026-03-10 | 2026-04-03 |
| Active Coping Program for Chronic Musculoskeletal Pain: A Controlled Clinical Study Active Coping Program, Usual Care - Chronic Musculoskeletal Pain, Chronic Pain | Not applicable | Completed | Universidad de Extremadura | 169 | 2026-02-01 | 2026-04-29 |
| Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Hip Osteoarthritis(OA) Joint Cavity Injection, MTrPs Injection - Myofascial Trigger Points, Chronic Musculoskeletal Pain | Not applicable | Recruiting | Beijing Tiantan Hospital | 1036 | 2025-12-01 | 2026-01-16 |
| Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Shoulder Osteoarthritis(OA) Joint Cavity Injection, MTrPs Injection - Myofascial Trigger Points, Chronic Musculoskeletal Pain | Not applicable | Recruiting | Beijing Tiantan Hospital | 1036 | 2025-12-01 | 2026-01-16 |
| Pain Disengagement Training (Open Pilot) Pain Disengagement Training - Chronic Musculoskeletal Pain | Not applicable | Recruiting | Massachusetts General Hospital | 10 | 2025-10-14 | 2026-08-21 |
| Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Knee Osteoarthritis(OA) MTrPs Injection, Intra-articular(IA) Injection - Myofascial Trigger Points, Migraine | Not applicable | Recruiting | Beijing Tiantan Hospital | 238 | 2025-10-01 | 2026-10-08 |
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Chronic Pain (18) · Musculoskeletal Pain (6) · Motor Activity (4) · Pain (4) · Stress Disorders, Post-Traumatic (3) · Pulmonary Disease, Chronic Obstructive (2) · Tennis Elbow (2) · Agnosia (1) · Anxiety Disorders (1) · Arthralgia (1) · Autonomic Nervous System Diseases (1) · Depression (1) · Dyspnea (1) · Frailty (1) · Lymphoma, Follicular (1)
Pathological Conditions, Signs and Symptoms (25) · Neurologic Manifestations (24) · Signs and Symptoms (24) · Pain (19) · Musculoskeletal Diseases (10) · Muscular Diseases (7) · Behavior (5) · Mental Disorders (5) · Nervous System Diseases (4) · Joint Diseases (3) · Pathologic Processes (3) · Stress Disorders, Traumatic (3) · Trauma and Stressor Related Disorders (3) · Arm Injuries (2) · Chronic Disease (2)
Physical Therapy Modalities (3) · Cognitive Behavioral Therapy (2) · Exercise Therapy (2) · Resistance Training (2) · salicylhydroxamic acid (2) · Cholecalciferol (1) · Cryosurgery (1) · DMAC2L protein, human (1) · Dosage Forms (1) · Educational Status (1) · Estradiol (1) · Exercise (1) · Exercise Test (1) · Injections (1) · Mass Screening (1)
VA Office of Research and Development (7) · University of Thessaly (5) · Aveiro University (4) · Beijing Tiantan Hospital (3) · Wayne State University (3) · Aarogyam UK (2) · Reuth Rehabilitation Hospital (2) · The Hong Kong Polytechnic University (2) · Universitat Jaume I (2) · University of Malaga (2) · Aalborg University (1) · Acibadem University (1) · Ana Catarina Navarro Ramalho (1) · Associação Pan-Americana Multidisciplinar de Endocanabinologia (1) · Centro Universitário Augusto Motta (1)
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Alejandro Luque Suarez, PhD (2) · Eleni Kapreli, PhD (2) · Marilyn L. Moy, MD (2) · Mark A Lumley, PhD (2) · Abhimanyu Kumar (1) · Adriaan P Louw, PhD (1) · Anabela G. Silva, PhD (1) · Bhavna Pandya (1) · Brandon C Yarns, MD MS BME (1) · Chao Hsing Yeh, PhD (1) · Dane B. Cook, PhD (1) · Darren C Greenwood, PhD (1) · David Kohns, MD (1)
PMID 20104399, PMID 26800632, PMID 31094345, PMID 33025213, PMID 36429591, PMID 37363989, PMID 37788078, PMID 38437926, PMID 39258762, PMID 39422992, PMID 39514886, PMID 41399479, PMID 41771006, PMID 41881815, PMID 41933837, PMID 42144560, PMID 42873771
I01HX003494 (1), K23AT012789 (1), P30AG028740 (1), R01AT013603 (1), R61NS118651 (1), UL1TR001420 (1)