41 completed, 24 unknown, 18 recruiting, 10 terminated. 114 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 114 | Completed 41, Unknown 24, Recruiting 18, Terminated 10, Active not recruiting 7, Not yet recruiting 7, Withdrawn 5, Enrolling by invitation 1, Suspended 1 |
Follow Chronic Limb-Threatening Ischemia: new trials by email Literature Review of Chronic Limb-Threatening Ischemia trials Research Report on Chronic Limb-Threatening Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DCB Outcomes After Non-Compliant Balloon Vessel Preparation With or Without Scoring in Patients With Femoropopliteal Arterial Disease Non-compliant Plain Balloon angioplasty (PBA), Non-compliant Scoring Balloon Angioplasty (SB) - Femoropopliteal Disease, Drug Coated Balloon | Not applicable | Not yet recruiting | Marc Sirvent | 142 | 2026-12-01 | 2026-10-07 |
| IVUS Guidance in BTK Interventions Intravascular ultrasound-guided EVT, Angiography-guided EVT - Chronic Limb-Threatening Ischemia | Not applicable | Not yet recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 212 | 2026-08-01 | 2026-07-28 |
| Drug Eluting Temporary Spur Stent System vs Percutaneous Balloon Angioplasty for the Treatment of Critical Limb Ischemia Drug Eluting Temporary Spur Stent System, Percutaneous Transluminal Balloon Angioplasty - Critical Limb Ischemia | Not applicable | Not yet recruiting | ReFlow Medical, Inc. | 518 | 2026-08-01 | 2026-01-07 |
| Home-based Exercise Therapy in Patients With Moderate to Severe Peripheral Artery Disease Home-Based Exercise Therapy Using Portable Pedal Exerciser - Peripheral Artery Disease | Not applicable | Recruiting | Laval University | 12 | 2026-06-23 | 2026-06-26 |
| Woundsome Revascularization in Chronic Limb-Threatening Ischemia Revascularization by Percutaneous Transluminal Angioplasty - Chronic Limb-Threatening Ischemia | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-04-01 | 2026-04-01 |
| Transverse Tibial Transport for Chronic Limb-Threatening Ischemia (CLTI) Transverse Tibial Bone Transport, TrueLok Elevate - Chronic Limb Threatening Ischemia | Not applicable | Withdrawn | University Hospitals Cleveland Medical Center | 2026-01-05 | 2026-05-29 | |
| Intravascular Ultrasound for Peripheral Artery Disease Revascularization IVUS-guided strategy - Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia | Not applicable | Recruiting | Hamilton Health Sciences Corporation | 772 | 2025-12-05 | 2026-09-18 |
| AcoArt Litos PCB Below-the-knee Global Trial PCB, PTA - Chronic Limb-Threatening Ischemia | Not applicable | Terminated | Acotec Scientific Co., Ltd | 75 | 2025-10-10 | 2026-08-26 |
| Pressure Wire Guidance for Infrapopliteal Artery Interventions Angiography-guided angioplasty, Pressure wire-guided angioplasty - Chronic Limb-Threatening Ischemia | Not applicable | Recruiting | Yonsei University | 100 | 2025-10-02 | 2025-12-02 |
| Outcomes of Atherectomy and Balloon Angioplasty Compared to Conventional Angioplasty in Infra-popliteal Chronic Limb-Threatening Ischemia atherectomy, Percutaneous transluminal angioplasty of infra-popliteal arteries lesions with primary long - Chronic Limb Threatening Ischemia | Not applicable | Not yet recruiting | Assiut University | 60 | 2025-09-30 | 2025-08-13 |
| Peripheral Microvascular Resistance as a Predictor for Limb Salvage Peripheral vascular flow reserve measurement - Peripheral Arterial Disease | Not applicable | Withdrawn | Hackensack Meridian Health | 2025-09-15 | 2025-09-24 | |
| Comprehensive Limb Evaluation and Arterial Revascularization With Toe Pressure Optimization Registry intensive toe pressure evaluation, data collection - Critical Limb Ischemia (CLI) | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 200 | 2025-07-07 | 2025-06-10 |
| Revascularization of Single Vesrus Multiple Infrapopliteal Vessels in Chronic Limb Threatening Ischemia balloon angioplasty - Chronic Limb Threatening Ischemia, Infrapopliteal Arterial Occlusive Disease | Not applicable | Recruiting | Sohag University | 40 | 2025-06-25 | 2025-07-16 |
| Initial Feasibility Study of the STENTiT Resorbable Fibrillated Scaffold (RFS). The RFS is Intended to Restore Lumen Patency and Blood Flow to Infrapopliteal Arteries. The RFS is a Fully Electrospun Tubular Device With a Fibrillated Microarchitecture and Designed for Transcatheter Delivery Implantation of RFS - Critical Limb Ischemia (CLI) | Not applicable | Recruiting | Stentit | 10 | 2025-06-03 | 2025-07-09 |
| Bioresorbable Sirolimus-Eluting Scaffold Treatment for Below the Knee Disease MAGNITUDE Sirolimus-eluting Bioresorbable Scaffold, Percutaneous Transluminal Angioplasty (PTA) - Chronic Limb-Threatening Ischemia | Not applicable | Recruiting | R3 Vascular Inc. | 300 | 2025-04-11 | 2026-02-06 |
| Duplex UltraSound afTer Endo Revascularisation - Feasibility Randomised Control Trial (DUSTER) Ultrasound Surveillance - Chronic Limb Threatening Ischaemia | Not applicable | Active not recruiting | Mid and South Essex NHS Foundation Trust | 70 | 2025-03-14 | 2025-12-30 |
| Heat Therapy for Peripheral Arterial Disease (HEATPAD) AirGlove - Peripheral Arterial Disease, Intermittent Claudication | Not applicable | Withdrawn | Norfolk and Norwich University Hospitals NHS Foundation Trust | 2025-01-01 | 2026-06-09 | |
| Single Versus Multiple Vessels Endovascular Tibial Arteries Revascularization for Critical Limb Ischemia Endovascular Revascularization - Critical Limb Ischemia, Tibialis Vessels Occlusion | Not applicable | Completed | Aswan University | 40 | 2025-01-01 | 2026-02-03 |
| FastWire REvascularisation of Extremities, (For LOWer Limbs) - FREEFLOW FastWire System - Peripheral - Chronic Total Occlusion of Artery of the Extremities | Not applicable | Recruiting | Versono Medical Ltd | 65 | 2024-11-05 | 2026-08-20 |
| Serrantor OCT Study Serranator PTA Serration Catheter, PTA (Standard of Care) - Critical Limb Ischemia | Not applicable | Recruiting | Cagent Vascular LLC | 60 | 2024-10-31 | 2025-05-18 |
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Peripheral Arterial Disease (46) · Intermittent Claudication (13) · Peripheral Vascular Diseases (12) · Diabetic Foot (5) · Arterial Occlusive Diseases (3) · Atherosclerosis (3) · Diabetes Mellitus (2) · Foot Ulcer (2) · Gangrene (2) · Ischemia (2) · Leg Ulcer (2) · Mobility Limitation (2) · Vascular Diseases (2) · Acute Coronary Syndrome (1)
Disease Attributes (114) · Pathologic Processes (114) · Pathological Conditions, Signs and Symptoms (114) · Arteriosclerosis (113) · Cardiovascular Diseases (113) · Chronic Disease (113) · Ischemia (112) · Vascular Diseases (112) · Arterial Occlusive Diseases (111) · Atherosclerosis (111) · Peripheral Vascular Diseases (102) · Peripheral Arterial Disease (68) · Signs and Symptoms (14) · Skin Diseases (8) · Skin and Connective Tissue Diseases (8)
Angioplasty (7) · Angioplasty, Balloon (3) · Atherectomy (2) · Control Groups (2) · Standard of Care (2) · Angioplasty, Balloon, Coronary (1) · Conversion to Open Surgery (1) · Data Collection (1) · Exercise (1) · Exercise Test (1) · Filgrastim (1) · Fish Oils (1) · Hyperbaric Oxygenation (1) · Polytetrafluoroethylene (1) · Sodium Chloride (1)
Abbott Medical Devices (5) · ReFlow Medical, Inc. (4) · Cagent Vascular LLC (3) · LimFlow, Inc. (3) · Medtronic Endovascular (3) · Philips Clinical & Medical Affairs Global (3) · Singapore General Hospital (3) · Assiut University (2) · Biotyx Medical (Shenzhen) Co., Ltd. (2) · Cook Group Incorporated (2) · Hull University Teaching Hospitals NHS Trust (2) · LimFlow SA (2) · Marc Sirvent (2) · Meshalkin Research Institute of Pathology of Circulation (2) · Ospedale San Donato (2)
United States (38) · Austria (13) · Germany (10) · Canada (8) · Italy (8) · United Kingdom (7) · New Zealand (6) · Singapore (6) · Belgium (5) · Australia (4) · Egypt (4) · Taiwan (4) · France (3) · Russia (3) · South Korea (3)
Marianne Brodmann, MD (4) · Jihad Mustapha, MD (3) · Mehdi Shishehbor (3) · Daniel Clair, MD (2) · Dierk Scheinert, MD (2) · Tjun Yip Tang (2) · Adrian Ebner, MD (1) · Ali Mahmoud Galal, MD of vascular surgery (1) · Alik Farber, MD (1) · Alun H Davies, BA BMChB MA (1) · Amarjit S Arneja, MD (1) · Andrej Schmidt, PD Dr. (1) · Anita Patteet, MD (1) · Ankur Thapar, PhD (1) · Antonella Biello, MD (1)
PMID 26062950, PMID 22498564, PMID 23915883, PMID 25650396, PMID 27402237, PMID 29430981, PMID 29748311, PMID 30683195, PMID 30819976, PMID 31010516, PMID 31200280, PMID 31993252, PMID 33126838, PMID 33221224, PMID 33296560, PMID 33314979, PMID 33825577, PMID 34019990, PMID 34602386, PMID 35156451, PMID 35175691, PMID 35252240, PMID 35352604, PMID 36342173, PMID 36435274, PMID 36601736, PMID 36617410, PMID 36648583, PMID 36988592, PMID 37040850, PMID 37139350, PMID 37318428, PMID 37888915, PMID 38353265, PMID 38626847, PMID 38906430, PMID 38990250, PMID 39069016, PMID 39332785, PMID 39368637, PMID 39638100, PMID 39846933, PMID 39880293, PMID 39914761, PMID 39923916, PMID 39960937, PMID 39984143, PMID 40100950, PMID 40138771, PMID 40287606
R21AG073769 (1), U01HL107407 (1)