12 completed, 6 unknown, 1 active not recruiting, 1 not yet recruiting. 6 Not applicable, 6 Phase 1, 4 Phase 2, 3 Phase 3, 1 Phase 4.
Follow Gangrene: new trials by email Literature Review of Gangrene trials Research Report on Gangrene
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males Fulvestrant, Anastrozole (ARIMIDEX™) - Inguinal Hernia Unilateral, Inguinal Hernia Bilateral | Phase 1 | Recruiting | Northwestern University | 30 | 2026-10-02 | 2026-10-06 |
| Evaluating the Efficacy and Safety of a New Laparoscopic Non-mesh Hernia Needle Set Designed for Indirect Inguinal Hernia non-mesh inguinal hernia needle, conventional needle set - Inguinal Hernia, Without Mention of Obstruction or Gangrene | Not applicable | Active not recruiting | Chang Gung Memorial Hospital | 96 | 2026-03-04 | 2026-10-28 |
| Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters Multicath, Standard of Care (SOC) - Peripheral Arterial Disease Below the Knee, Peripheral Arterial Disease, Rutherford 4 and 5 with Possibility to Improve Vascularization | Not applicable | Not yet recruiting | Summa Therapeutics, LLC | 24 | 2025-04-03 | 2025-04-02 |
| MetaMet: Bone Cutter Versus Bone Saw for Ray Amputation Bone Saw, Bone Cutter - Diabetic Foot, Gangrene; Limb | Not applicable | Unknown | University College Hospital Galway | 40 | 2023-01-01 | 2023-04-07 |
| Risk Factors for Necrotic Cholecystitis During COVID-19 Pandemic. Cholecystitis, Acute, Cholecystitis; Gangrenous | Unknown | Poissy-Saint Germain Hospital | 800 | 2020-10-01 | 2021-03-26 | |
| Effect of Evolocumab in Patients With Critical Limb Ischemia (Evol-CLI) Evolocumab 140mg/mL Injector 1milliliter (mL) Pen x 3 for a monthly dose of 420 mg for 12 months., Placebo 1 milliliter (mL) Injector Pen x 3 monthly for 12 months - Critical Limb Ischemia | Phase 4 | Unknown | Leonardo Clavijo | 32 | 2020-02-24 | 2020-03-13 |
| ESTES Snapshot Audit 2018 Cholangitis; Gallstone, Pancreatitis Gallstone | Completed | European Society for Trauma and Emergency Surgery | 250 | 2018-10-01 | 2019-07-05 | |
| Closed Suction Drain vs no Drain on Symptomatic Seroma Formation After Laparoscopic Inguinal Hernia Repair Laparoscopic Inguinal Hernia (TEP/TAPP) Surgery - Inguinal Hernia Without Obstruction or Gangrene | Not applicable | Completed | GEM Hospital & Research Center | 100 | 2018-08-01 | 2020-10-14 |
| Autologous Transplantation of BM-ECs With Platelet-Rich Plasma Extract for the Treatment of Critical Limb Ischemia BM-ECs and PRPE, BM-ECs - Leg Ulcer, Diabetic Foot | Phase 1 | Unknown | South China Research Center for Stem Cell and Regenerative Medicine | 40 | 2018-03-01 | 2016-12-15 |
| Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Aggressive debridement - Fournier Gangrene, Fournier's Gangrene of Penis | Completed | Hospital Universitario Dr. Jose E. Gonzalez | 121 | 2017-11-01 | 2018-02-23 | |
| ADMSCs for the Treatment of Systemic Sclerosis injection of autologous stromal vascular fraction - Systemic Sclerosis | Not applicable | Completed | The Catholic University of Korea | 7 | 2016-10-25 | 2018-01-25 |
| Safety and Efficacy of Autologous Bone Marrow Stem Cells for Lower Extremity Ischemia Treating BM-MNC injection - Lower Extremity Ischemia, Leg Ulcer | Phase 1 / Phase 2 | Unknown | Pontifícia Universidade Católica do Paraná | 60 | 2014-09-01 | 2017-12-13 |
| Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia Open surgical revascularization, Endovascular revascularization - Critical Limb Ischemia | Not applicable | Completed | Carelon Research | 1843 | 2014-08-01 | 2023-04-11 |
| Tension-free Repair of Inguinal Hernia With "Undissociate Spermatic Cord" Tension-free repair of inguinal hernia with "Undissociate Spermatic cord" - Inguinal Hernia, Without Mention of Obstruction or Gangrene | Completed | Harbin Medical University | 134 | 2014-03-01 | 2022-02-21 | |
| Autologous Adipose-Derived Stromal Cell Delivered Via Intramuscular Injections for the Treatment of Critical Limb Ischemia Liposuction, Stem Cell Injection - Critical Limb Ischemia | Phase 1 | Withdrawn | Ageless Regenerative Institute | 2014-03-01 | 2017-07-21 | |
| Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells Peripheral blood mononuclear cell - Critical Limb Ischemia, Atherosclerosis | Phase 3 | Completed | Mahidol University | 8 | 2013-04-01 | 2018-08-17 |
| Biomarkers in Patients With Flesh-eating Bacterial Infections Necrotizing Soft Tissue Infection, Necrotizing Fasciitis | Completed | Ole Hyldegaard | 169 | 2013-02-01 | 2016-02-17 | |
| Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Hyperbaric oxygen therapy - Necrotizing Soft Tissue Infection, Necrotizing Fascitis | Completed | Ole Hyldegaard | 260 | 2013-02-01 | 2019-06-24 | |
| A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma Tadalafil, Placebo - Raynaud's Phenomenon, Digital Ulcers | Phase 3 | Completed | Sanjay Gandhi Postgraduate Institute of Medical Sciences | 66 | 2009-11-01 | 2010-05-10 |
| Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Autologous bone marrow cell concentrate transplantation, saline injection - Peripheral Vascular Disease, Diabetic Foot | Phase 2 / Phase 3 | Unknown | Franziskus-Krankenhaus | 90 | 2007-04-01 | 2011-04-06 |
Showing 20 of 22. Sign in to see all of them.
Chronic Limb-Threatening Ischemia (6) · Leg Ulcer (6) · Peripheral Vascular Diseases (6) · Ischemia (5) · Diabetic Foot (4) · Fournier Gangrene (3) · Hernia, Inguinal (3) · Peripheral Arterial Disease (3) · Arterial Occlusive Diseases (2) · Atherosclerosis (2) · Bacterial Infections (2) · Cholecystitis (2) · Disease (2) · Fasciitis (2)
Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Necrosis (20) · Cardiovascular Diseases (12) · Skin Diseases (11) · Skin and Connective Tissue Diseases (11) · Vascular Diseases (11) · Arteriosclerosis (8) · Arterial Occlusive Diseases (7) · Chronic Disease (7) · Disease Attributes (7) · Skin Ulcer (7) · Atherosclerosis (6) · Peripheral Vascular Diseases (6) · Endocrine System Diseases (5)
Anastrozole (1) · Fulvestrant (1) · Hyperbaric Oxygenation (1) · Lipectomy (1) · Sodium Chloride (1) · Surgical Procedures, Operative (1) · Tadalafil (1) · evolocumab (1)
Ole Hyldegaard (2) · Ageless Regenerative Institute (1) · Carelon Research (1) · Chang Gung Memorial Hospital (1) · European Society for Trauma and Emergency Surgery (1) · Franziskus-Krankenhaus (1) · GEM Hospital & Research Center (1) · Harbin Medical University (1) · Hospital Universitario Dr. Jose E. Gonzalez (1) · Leonardo Clavijo (1) · Mahidol University (1) · Northwestern University (1) · Poissy-Saint Germain Hospital (1) · Pontifícia Universidade Católica do Paraná (1) · Sanjay Gandhi Postgraduate Institute of Medical Sciences (1)
United States (5) · Denmark (2) · India (2) · Ireland (2) · Brazil (1) · Canada (1) · Finland (1) · France (1) · Germany (1) · Italy (1) · Japan (1) · Mexico (1) · Netherlands (1) · New Zealand (1) · South Korea (1)
Ole Hyldegaard, MD, PhD (2) · Alik Farber, MD (1) · Aman Sharma, MD (1) · Amy Gillis, MD, MCh, FRCSC (1) · Berthold Amann, MD (1) · Chinnusamy Palanivelu, MS,MCh,FRCS,FACS (1) · Darshan S Bhakuni, MD (1) · Frans L Moll, MD, PhD (1) · Gary A Bass, MD, MSc, MBA (1) · Jorge Pereira, MD, FACS (1) · Jung Hee Koh, MD (1) · Kenneth Rosenfield, MD (1) · Leonardo Clavijo, MD, PhD (1) · Marco Bo Hansen, MD (1) · Marianne C Verhaar, MD, PhD (1)
PMID 10843398, PMID 15319657, PMID 19711453, PMID 22877866, PMID 24218170, PMID 25567765, PMID 25692427, PMID 25967993, PMID 26148006, PMID 26186803, PMID 26428987, PMID 26880104, PMID 27402237, PMID 28982834, PMID 30683195, PMID 30863805, PMID 30867674, PMID 31010516, PMID 32082310, PMID 33004858, PMID 33144352, PMID 33314979, PMID 33813631, PMID 33825577, PMID 35802393, PMID 36342173, PMID 36435274, PMID 37040850, PMID 37318428, PMID 37929840, PMID 38626847, PMID 38775981, PMID 38906430, PMID 39069016, PMID 39332785, PMID 39368637, PMID 39638100, PMID 39846933, PMID 39880293, PMID 39914761, PMID 39923916, PMID 39984143, PMID 40100950, PMID 40138771, PMID 40464723, PMID 40484061, PMID 40885461, PMID 40886741, PMID 41242623, PMID 41453560
U01HL107407 (1)