2 completed, 2 unknown, 1 recruiting. 5 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 5 | Completed 2, Unknown 2, Recruiting 1 |
Follow Chronic Limb-Threatening Ischemia: new trials by email Literature Review of Chronic Limb-Threatening Ischemia trials Research Report on Chronic Limb-Threatening Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety, Tolerability, and Biodistribution of [89Zr]Zr-DFO-APAC in Subjects With PAOD/CLI and Healthy Volunteers (Acronyms: 89Zr = Zirconium-89, DFO = Desferrioxamine, APAC = AntiPlatelet AntiCoagulant, PET/CT = Positron Emission Tomography/Computed Tomography) [89Zr]Zr-DFO-APAC, PET/CT scan - Peripheral Arterial Occlusive Disease, Critical Limb Ischemia | Early Phase 1 | Unknown | Aplagon Oy | 10 | 2024-02-01 | 2025-01-30 |
| Umbilical Cord Artery-derived Perivascular Stem Cells for the Critical Limb Ischemia Therapy UCA-PSCs/bFGF or bFGF Intramuscular injection - Critical Limb Ischemia | Early Phase 1 | Unknown | Nanjing University | 40 | 2023-06-30 | 2023-12-18 |
| Nutrition in Patient With Critical Limb Ischemia Ensure Surgery Immunonutrition Shake, Ensure Enlive Advanced Nutrition Shake - Critical Limb Ischemia, Malnutrition | Early Phase 1 | Recruiting | Boston Medical Center | 30 | 2018-10-02 | 2026-09-29 |
| N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes Active Arm N-acetyl cysteine (NAC), Placebo Arm - Diabetes Mellitus, Critical Limb Ischemia | Early Phase 1 | Completed | Washington University School of Medicine | 33 | 2017-03-01 | 2024-08-16 |
| Chelation Therapy in Diabetic Patients With Critical Limb Ischemia disodium EDTA - Critical Limb Ischemia, Peripheral Arterial Disease | Early Phase 1 | Completed | Mt. Sinai Medical Center, Miami | 11 | 2015-08-01 | 2019-06-10 |
Peripheral Arterial Disease (2) · Diabetes Mellitus (1) · Malnutrition (1) · Peripheral Arterial Occlusive Disease 1 (1)
Arterial Occlusive Diseases (5) · Arteriosclerosis (5) · Atherosclerosis (5) · Cardiovascular Diseases (5) · Chronic Disease (5) · Disease Attributes (5) · Ischemia (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Peripheral Vascular Diseases (5) · Vascular Diseases (5) · Peripheral Arterial Disease (3) · Nutritional and Metabolic Diseases (2) · Endocrine System Diseases (1) · Glucose Metabolism Disorders (1)
Acetylcysteine (1) · Chelation Therapy (1) · Edetic Acid (1)
Aplagon Oy (1) · Boston Medical Center (1) · Mt. Sinai Medical Center, Miami (1) · Nanjing University (1) · Washington University School of Medicine (1)
United States (3) · China (1) · Netherlands (1)
Gervasio Lamas, MD (1) · Haiming Xia, phD (1) · Jeffrey J Siracuse, MD (1) · Mohamed Zayed, MD (1) · Schelto Kruijff, MD, Prof (1)
2023 (1)