8 completed, 6 unknown, 3 recruiting, 2 terminated. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Completed 8, Unknown 6, Recruiting 3, Terminated 2, Not yet recruiting 1 |
Follow Chronic Limb-Threatening Ischemia: new trials by email Literature Review of Chronic Limb-Threatening Ischemia trials Research Report on Chronic Limb-Threatening Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 180 | 2026-10-20 | 2026-09-18 |
| VTE Incidence After Rivaroxaban + Aspirin or SAPT After Lower-limb Revascularization rivaroxaban 2.5 mg bid + aspirin 100 mg, clopidogrel 75 mg od for 3 months followed by aspirin 100 mg od for endovascular procedures or aspirin for open procedures - Peripheral Arterial Disease, Venous Thormboembolism | Phase 4 | Recruiting | Science Valley Research Institute | 100 | 2024-02-24 | 2025-03-12 |
| Efficacy and Safety of Stempeucel® in Patients With Critical Limb Ischemia (CLI) Due to Peripheral Arterial Disease Stempeucel® - Critical Limb Ischemia, Peripheral Arterial Disease | Phase 4 | Recruiting | Cell Biopeutics Resources Sdn Bhd | 10 | 2024-01-01 | 2025-09-09 |
| Efficacy and Safety of Stempeucel® in Patients With Critical Limb Ischemia (CLI) Due to Buerger's Disease Adult human bone marrow derived, cultured, pooled, allogeneic mesenchymal stromal cells - Critical Limb Ischemia, Buerger's Disease | Phase 4 | Recruiting | Cell Biopeutics Resources Sdn Bhd | 3 | 2024-01-01 | 2025-09-09 |
| Alprostadil as an Adjuvant Therapy With Indirect Angiosomal Revascularization in Critical Limb Ischemia. Alprostadil - Critical Limb Ischemia | Phase 4 | Unknown | Assiut University | 30 | 2020-04-01 | 2020-03-20 |
| Effect of Evolocumab in Patients With Critical Limb Ischemia (Evol-CLI) Evolocumab 140mg/mL Injector 1milliliter (mL) Pen x 3 for a monthly dose of 420 mg for 12 months., Placebo 1 milliliter (mL) Injector Pen x 3 monthly for 12 months - Critical Limb Ischemia | Phase 4 | Unknown | Leonardo Clavijo | 32 | 2020-02-24 | 2020-03-13 |
| ILLUMENATE Below-The-Knee (BTK) Arteries: a Post Market Clinical Study StellarexTM 0.014" Over-The-Wire Drug-coated Angioplasty Balloon - Peripheral Arterial Disease | Phase 4 | Completed | Spectranetics Corporation | 49 | 2018-04-20 | 2024-01-24 |
| Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) ), Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel, Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol - Critical Limb Ischemia | Phase 4 | Unknown | Yonsei University | 390 | 2017-02-21 | 2019-01-14 |
| Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Dexamethasone infusion, Drug coated balloon, Plain balloon angioplasty - Peripheral Artery Disease, Vascular Disease | Phase 4 | Completed | University of California, San Francisco | 33 | 2016-02-10 | 2025-07-17 |
| Drug Eluting Balloon Angioplasty Versus Nitinol Stent Implantation in the Superficial Femoral Artery Drug Eluting Balloon Angioplasty, Nitinol stenting - Peripheral Arterial Disease, Arterial Occlusive Diseases | Phase 4 | Completed | Instituto Dante Pazzanese de Cardiologia | 85 | 2014-07-01 | 2021-06-10 |
| Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation PEB, POBA - Critical Limb Ischemia | Phase 4 | Completed | Leonardo Bolognese, MD | 142 | 2010-11-01 | 2013-01-29 |
| Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) femoral-popliteal bypass, stent - Vascular Diseases, Diabetes | Phase 4 | Unknown | Peking Union Medical College Hospital | 70 | 2010-11-01 | 2012-12-24 |
| Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Percutaneous Transluminal Angioplasty, below-knee arterial bypass - Vascular Diseases, Diabetes | Phase 4 | Unknown | Peking Union Medical College Hospital | 130 | 2010-08-01 | 2012-12-24 |
| Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery stent, femoral-popliteal bypass with artificial blood vessel - Arterial Occlusive Diseases, Vascular Diseases | Phase 4 | Unknown | Peking Union Medical College Hospital | 200 | 2010-06-01 | 2010-07-07 |
| Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions iliac stenting - Peripheral Vascular Disease, Intermittent Claudication | Phase 4 | Completed | Flanders Medical Research Program | 325 | 2008-12-01 | 2013-01-25 |
| DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Everflex 200 - Peripheral Vascular Disease, Intermittent Claudication | Phase 4 | Completed | Flanders Medical Research Program | 100 | 2008-03-01 | 2010-12-01 |
| Cryoplasty CLIMB-registry PolarCath Peripheral Dilatation System (Boston Scientific) - Critical Limb Ischemia, Peripheral Arterial Occlusive Disease | Phase 4 | Completed | Flanders Medical Research Program | 100 | 2007-05-01 | 2010-07-05 |
| Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Bypass, Silverhawk Plaque Excision - Peripheral Vascular Diseases | Phase 4 | Terminated | FoxHollow Technologies | 2006-10-01 | 2008-08-20 | |
| Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia pregabalin, placebo - Critical Limb Ischemia, Arterial Occlusive Disease | Phase 4 | Terminated | Karolinska Institutet | 18 | 2006-06-01 | 2018-06-15 |
| Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) 6 mm Uni-graft® (B-Braun), 6 mm Gore-Tex® (WL Gore) - Intermittent Claudication, Critical Limb Ischemia | Phase 4 | Completed | University Hospital, Gentofte, Copenhagen | 400 | 1993-10-01 | 2006-03-09 |
Peripheral Arterial Disease (7) · Intermittent Claudication (5) · Peripheral Vascular Diseases (5) · Vascular Diseases (4) · Arterial Occlusive Diseases (3) · Atherosclerosis (2) · Cardiovascular Diseases (2) · Diabetes Mellitus (2) · Ischemia (2) · Peripheral Arterial Occlusive Disease 1 (2) · Agnosia (1) · Arteriosclerosis (1) · Carotid Stenosis (1) · Diabetic Foot (1)
Chronic Disease (20) · Disease Attributes (20) · Pathologic Processes (20) · Pathological Conditions, Signs and Symptoms (20) · Arteriosclerosis (19) · Atherosclerosis (18) · Cardiovascular Diseases (18) · Ischemia (18) · Arterial Occlusive Diseases (17) · Vascular Diseases (16) · Peripheral Vascular Diseases (15) · Peripheral Arterial Disease (13) · Signs and Symptoms (6) · Endocrine System Diseases (3) · Glucose Metabolism Disorders (2)
Aspirin (2) · Clopidogrel (2) · Stents (2) · Alprostadil (1) · Angioplasty (1) · BID protein, human (1) · Cilostazol (1) · Endovascular Procedures (1) · Pregabalin (1) · Rivaroxaban (1) · evolocumab (1)
Flanders Medical Research Program (3) · Peking Union Medical College Hospital (3) · Cell Biopeutics Resources Sdn Bhd (2) · Assiut University (1) · First Affiliated Hospital of Wenzhou Medical University (1) · FoxHollow Technologies (1) · Instituto Dante Pazzanese de Cardiologia (1) · Karolinska Institutet (1) · Leonardo Bolognese, MD (1) · Leonardo Clavijo (1) · Science Valley Research Institute (1) · Spectranetics Corporation (1) · University Hospital, Gentofte, Copenhagen (1) · University of California, San Francisco (1) · Yonsei University (1)
China (4) · Belgium (3) · United States (3) · Brazil (2) · Malaysia (2) · Germany (1) · Italy (1) · Netherlands (1) · South Korea (1) · Sweden (1) · United Kingdom (1)
Marc Bosiers, MD (3) · Hanafiah Harunarashid, MS (2) · Ashraf Elnaggar, Dr (1) · David Saloner, PhD (1) · Eduardo Ramacciotti, MD, Ph.D. (1) · Eric Wahlberg, MD. PhD (1) · Frank Vermassen, MD (1) · Gunnar Tepe, MD (1) · Hassan Bakr El-Badawy, Prof (1) · James F. McKinsey, M.D. (1) · Leonardo Clavijo, MD, PhD (1) · Liu Changwei, bachelor (1)
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R01HL128816 (1)