196 completed, 80 unknown, 30 recruiting, 24 terminated. 139 Not applicable, 45 Phase 2, 34 Phase 3, 30 Phase 4, 25 Phase 1.
Follow Chronic Heart Failure: new trials by email Literature Review of Chronic Heart Failure trials Research Report on Chronic Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Voice-based Outcome Identification and Clinical Evaluation in Heart Failure Daily Voice Recording - Heart Failure, Chronic Heart Failure | Not yet recruiting | Noah Labs | 450 | 2026-10-01 | 2026-10-14 | |
| A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic Heart Failure Subcutaneous cardiac microcurrent treatment - Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction | Not applicable | Not yet recruiting | Berlin Heals GmbH | 60 | 2026-09-01 | 2026-08-31 |
| Yiqi Fumai Lyophilized Injection for Chronic Heart Failure Caused by Coronary Heart Disease Yiqi Fumai Lyophilized Injection(YQFM), Stable Guideline-Directed Medical Therapy - Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Not yet recruiting | China Academy of Chinese Medical Sciences | 100 | 2026-09-01 | 2026-09-09 |
| Evaluation of the Clinical Value of NT-proBNP (or BNP) Measurement, Alone or in Combination With the EPOF Questionnaire, for the Screening of Chronic Heart Failure (CHF) in Adults Aged 40 Years and Older Referred for a Cardiology Consultation Without Suspected CHF. NT-pro-BNP, NT-proBNP | Not yet recruiting | French Cardiology Society | 1000 | 2026-09-01 | 2026-09-23 | |
| Therapy Adjustment and IndividuaLized Response With Biomarker Observation in ReaL-world Heart Failure Chronic Heart Failure, Acute Decompensated Heart Failure | Not yet recruiting | Maastricht University Medical Center | 600 | 2026-09-01 | 2026-06-15 | |
| Real-World Effectiveness and Costs of Yiqi Fumai Lyophilized Injection in Coronary Heart Disease-Related Chronic Heart Failure Yiqi Fumai Lyophilized Injection - Chronic Heart Failure, Coronary Heart Disease (CHD) | Not yet recruiting | China Academy of Chinese Medical Sciences | 200 | 2026-09-01 | 2026-09-25 | |
| TELEREHAB-BR: Cardiovascular Rehabilitation Models Trial Hybrid Cardiac Telerehabilitation, Traditional Center-Based Cardiac Rehabilitation (TCR), Usual Care Group - Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Chronic Heart Failure | Not applicable | Not yet recruiting | University of the State of Santa Catarina | 219 | 2026-08-03 | 2026-07-29 |
| A Study to Evaluate the Safety, Pharmacokinetics of AD-118 and AD-1181 in Healthy Adult Subjects AD-118, AD-1181 - Chronic Heart Failure | Phase 1 | Not yet recruiting | Addpharma Inc. | 74 | 2026-07-24 | 2026-07-21 |
| A CSM-Based Volume Management Program for Chronic Heart Failure CSM-Based Intervention Group, Standard Care (in control arm) - Chronic Heart Failure | Not applicable | Not yet recruiting | The Third Xiangya Hospital of Central South University | 88 | 2026-07-03 | 2026-07-07 |
| Fecal Microbiota Transplantation for Elderly Patients With HFpEF: A Randomized Controlled Trial Fecal Microbiota Transplantation (FMT) Capsules, Placebo capsules - Heart Failure With Preserved Ejection Fraction (HFPEF), Chronic Heart Failure | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 50 | 2026-06-01 | 2026-06-05 |
| A Study to Evaluate the Safety and Pharmacokinetics of AD-118 and AD-1181 in Healthy Adult Subjects AD-118, AD-1181 - Chronic Heart Failure | Phase 1 | Not yet recruiting | Addpharma Inc. | 70 | 2026-04-01 | 2026-03-17 |
| Mobile-Based Telemedicine and Health-Related Quality of Life Among Patients With Chronic Heart Failure (MOBILE-HF) Supportive Care - Chronic Heart Failure, Health Related Quality of Life | Not applicable | Recruiting | Select College | 72 | 2026-03-02 | 2026-06-17 |
| Nurse-Led Education for Heart Failure Self-Care and Stability Nurse-Led Face-to-Face Educational Intervention (Teach-Back Method) - Chronic Heart Failure | Not applicable | Not yet recruiting | Azienda Socio Sanitaria Territoriale di Lodi | 118 | 2026-02-01 | 2025-12-12 |
| PREcision meDICine in Treatment in CardioVascular Disease ASSIST-HF AI- algorithm, Standard of Care (Investigator Choice) - Chronic Heart Failure, Acute Decompensated Heart Failure | Not applicable | Withdrawn | Maastricht University Medical Center | 2026-02-01 | 2026-04-17 | |
| Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not yet recruiting | Xinjiang Medical University | 600 | 2026-01-01 | 2026-01-21 | |
| A Phase I/II Clinical Trial of Intramyocardial Injection of HucMSCs for the Treatment of Chronic Heart Failure Mesenchymal stem cells(HucMSCs), CABG - Coronary Artery Bypass Grafting (CABG), Chronic Heart Failure | Phase 1 / Phase 2 | Recruiting | Tasly Pharmaceutical Group Co., Ltd | 51 | 2025-12-26 | 2026-01-09 |
| A Study to Learn More About How Safe Finerenone is and How Well it Works in Adults With Chronic Heart Failure in South Korea finerenone (BAY94-8862) - Chronic Heart Failure | Recruiting | Bayer | 300 | 2025-12-23 | 2026-02-03 | |
| Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure low-volume high intensity interval training, High volume high intensity interval training, Standard medical treatment - Chronic Heart Failure | Not applicable | Recruiting | Cairo University | 45 | 2025-12-10 | 2026-01-08 |
| Biventricular or Left Bundle Branch Pacing to Assess the Effect of Cardiac Resynchronization Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation CRT implantation - Chronic Heart Failure | Not applicable | Recruiting | Semmelweis University Heart and Vascular Center | 360 | 2025-11-19 | 2026-02-25 |
| Vericiguat and Reverse Remodeling Indices in Heart Failure Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT) - Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure | Phase 4 | Recruiting | University Medical Centre Ljubljana | 70 | 2025-11-01 | 2026-09-29 |
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Heart Failure (72) · Pulmonary Disease, Chronic Obstructive (20) · Motor Activity (14) · Diabetes Mellitus (13) · Iron Deficiencies (11) · Cardiovascular Diseases (10) · Heart Diseases (10) · Hypertension (10) · Neoplasms (9) · Anemia (7) · Atrial Fibrillation (7) · Dyspnea (7) · Insulin Resistance (7) · Renal Insufficiency, Chronic (7) · Anemia, Iron-Deficiency (6)
Cardiovascular Diseases (109) · Heart Diseases (97) · Pathological Conditions, Signs and Symptoms (65) · Pathologic Processes (42) · Nutritional and Metabolic Diseases (41) · Metabolic Diseases (38) · Respiratory Tract Diseases (38) · Signs and Symptoms (29) · Disease Attributes (26) · Chronic Disease (25) · Glucose Metabolism Disorders (25) · Behavior (24) · Vascular Diseases (24) · Endocrine System Diseases (23) · Lung Diseases (22)
Exercise (10) · Standard of Care (8) · sacubitril and valsartan sodium hydrate drug combination (6) · Bisoprolol (5) · Cardiac Resynchronization Therapy (5) · Carvedilol (5) · empagliflozin (5) · ferric carboxymaltose (5) · vericiguat (5) · Ivabradine (4) · Acetazolamide (3) · Ferric Oxide, Saccharated (3) · Furosemide (3) · Growth Hormone (3) · Valsartan (3)
University of Leeds (8) · Federico II University (7) · Medtronic Cardiac Rhythm and Heart Failure (7) · Novartis Pharmaceuticals (7) · Zensun Sci. & Tech. Co., Ltd. (6) · AquaPass Medical Ltd. (4) · Bayer (4) · Maastricht University Medical Center (4) · University Hospital, Clermont-Ferrand (4) · University Hospital, Montpellier (4) · Vifor Pharma (4) · Bial - Portela C S.A. (3) · Cairo University (3) · Charite University, Berlin, Germany (3) · Duke University (3)
United States (57) · Germany (39) · Italy (36) · China (35) · France (34) · United Kingdom (27) · Netherlands (19) · Russia (19) · Poland (17) · Spain (16) · Canada (14) · Denmark (13) · Japan (12) · Austria (11) · Israel (10)
Francis Pagani, MD (2) · Jiangang Zou, MD,Ph.D (2) · Joseph Rogers, MD (2) · Piergiuseppe Agostoni, MD, PhD (2) · Runlin Gao, MD, Ph.D (2) · Shirley Wang, PhD, ScM (2) · Adrian Hernandez, MD,MHS,FAHA (1) · Adrian S. Dobs, MD, MHS (1) · Aharon Abbo, MD (1)
PMID 32740129, PMID 32740343, PMID 37542951, PMID 39423760, PMID 42149813, PMID 10507597, PMID 1098460, PMID 11156941, PMID 11264545, PMID 11497152, PMID 12094185, PMID 12215493, PMID 14522413, PMID 15090073, PMID 15133373, PMID 15364767, PMID 15364861, PMID 15753115, PMID 15879312, PMID 15931018, PMID 1595062, PMID 16352955, PMID 16374166, PMID 16563117, PMID 17466269, PMID 17630410, PMID 18191732, PMID 18279771, PMID 18431265, PMID 18496368, PMID 18701467, PMID 18760123, PMID 19114917, PMID 19477398, PMID 19491687, PMID 19618202, PMID 19770806, PMID 19789403, PMID 19793954, PMID 19875408, PMID 19920054, PMID 20036246, PMID 20101071, PMID 20227109, PMID 20562711, PMID 20663654, PMID 20723799, PMID 20730060, PMID 20801495, PMID 20801500
2015 (2), 2023 (2), 2004 (1), 2008 (1), 2009 (1), P20NR011404 (1), P50AT000437 (1), R01MH063211 (1), R21AG034557 (1), U10HL084904 (1)