48 completed, 22 terminated, 14 unknown, 9 recruiting. 107 Phase 2, 26 Phase 3, 24 Phase 1.
Follow Burns: new trials by email Literature Review of Burns trials Research Report on Burns
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients IP1 control cream (Vehicle base), IP2 - 0.5% w/w FS2 - Burn Scar, Burn Wound | Phase 2 / Phase 3 | Recruiting | Birch BioMed Inc | 70 | 2027-03-01 | 2026-09-30 |
| HUMSCs Combined With Col I to Third-Degree Burn Wound HUMSCs combined with bovine type I collagen, bovine type I collagen, Sterile blank dressing / Vaseline gauze - Burn Wounds, Third-Degree Burn Wounds | Phase 1 / Phase 2 | Recruiting | The First Affiliated Hospital of Xinxiang Medical College | 108 | 2026-04-06 | 2026-05-04 |
| Treatment of Severe Ocular Chemical Burns by Subconjunctival Injection of Allogeneic Mesenchymal Stem Cells: An Open-Label, Single-Arm, Multicenter Phase II Trial Subconjunctival injection of 1 mL with 5 million allogeneic BM-MSCs; one repeat within 21 days. - Chemical Burns, Ocular Burns | Phase 2 | Not yet recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 21 | 2026-03-01 | 2026-01-09 |
| 4-Aminopyridine to Treat Skin Burns Drug: 4-Aminopyridine, Placebo - Burns, Second Degree Burn | Phase 2 | Recruiting | John Elfar | 200 | 2026-01-01 | 2026-03-05 |
| Use of Progenitor Biological Bandages in Burn Care (Bru_PBB) Progenitor Biological Bandages, Jelonet - Burn Injury | Phase 1 / Phase 2 | Terminated | Dr Anthony De Buys Roessingh | 76 | 2025-07-01 | 2025-07-22 |
| Phase II Clinical Trial of KJ101in the Treatment of Deep II Degree Burns KJ101, Chymotrypsin, Placebo (Sodium Chloride Injection 0.9%) - Burn, Burn Wounds - Partial Thickness (2nd Degree) | Phase 2 | Recruiting | Shanghai Bao Pharmaceuticals Co., Ltd. | 144 | 2025-06-16 | 2025-06-17 |
| SN514-066b Enzyme in Deep Partial Thickness Burns SN514-066b - Burn Injury | Phase 1 / Phase 2 | Terminated | SERDA bv | 13 | 2025-05-08 | 2026-10-30 |
| A Study to Evaluate the Safety, Tolerability and Efficacy in Patients With Burn(s) PMS-101, Standard treatment - Burns, Burn Degree Second | Phase 1 / Phase 2 | Unknown | Primoris Therapeutics | 40 | 2025-01-01 | 2024-07-05 |
| A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn oxytocin, placebo - Sunburn | Phase 2 | Completed | Wake Forest University Health Sciences | 38 | 2024-12-05 | 2026-01-12 |
| Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults Glucose 30% Intravenous Solution - Burns, Intensive Care | Phase 2 | Recruiting | Centre Hospitalier Régional Metz-Thionville | 15 | 2024-11-28 | 2026-03-12 |
| The Effects of Metformin on Morbidity and Mortality in Elderly Patients Metformin, Placebos - Burns | Phase 2 | Not yet recruiting | Hamilton Health Sciences Corporation | 250 | 2024-11-01 | 2024-10-02 |
| Organ Protective Effect of Cetirizine In Patients With Severe Burns Cetirizine, Midazolam and Fentanyl - Burns | Phase 1 / Phase 2 | Unknown | Ruijin Hospital | 32 | 2024-01-23 | 2024-02-01 |
| Comparison Between Carbapenems and Noncarbapenem Beta-lactam Antibiotics in Septic Burn Patients Meropenem I.V. 2g as a 3 hour infusion every 8 hours, Tazocin (pipercillin/tazobactam) - Sepsis | Phase 1 / Phase 2 | Active not recruiting | Ain Shams University | 400 | 2024-01-01 | 2025-10-03 |
| Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn Ergocalciferol, Placebo - Burn Injury, Chronic Pain | Phase 2 | Completed | University of North Carolina, Chapel Hill | 40 | 2023-04-12 | 2026-05-05 |
| Mangosteen Gel for Sunburn-Like Skin Redness Caused by Ultraviolet B Light Topical Garcinia mangostana Pericarp Extract Gel 2.5%, Topical Garcinia mangostana Pericarp Extract Gel 5%, Topical Garcinia mangostana Pericarp Extract Gel 10% - Narrowband Ultraviolet B-Induced Skin Erythema, Erythema | Phase 2 | Completed | Hasanuddin University | 36 | 2022-08-20 | 2026-10-15 |
| Safety, Tolerability and Efficacy of Nefopam Cream in Burn Patients Nefopam, Placebo (Vehicle) - Burn; Multiple Body Regions, Max. Second Degree, Third-Degree Burn | Phase 2 | Completed | University of Alberta | 50 | 2022-07-10 | 2026-07-24 |
| Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns Investigational Drug, MW-III, Silvadene® Cream 1% [Silver Sulfadiazine] - Burns | Phase 2 | Recruiting | Skingenix, Inc. | 60 | 2022-03-11 | 2026-03-16 |
| Dermal Irritation, Sensitization and Cumulative Irritation Potential of 6% Bemotrizinol 6% Bemotrizinol (BEMT) in a basic sunscreen oil formulation, 6% Bemotrizinol (BEMT) dispersion in petrolatum, Sunscreen oil vehicle with 10% ethanol as penetration enhancer without BEMT - Sunburn | Phase 2 | Completed | dsm-firmenich Switzerland AG | 224 | 2022-02-23 | 2022-08-26 |
| Comparison of Fluid Resuscitation in Pediatric Burn Patients Using Crystalloids and With Albumin on Day Two. 5% Albumin (human) Solution, Paeds solution - Burns | Phase 2 / Phase 3 | Completed | King Edward Medical University | 90 | 2022-01-01 | 2024-01-25 |
| A Between Patient Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries PluroGel, Standard dressing - Burns | Phase 1 / Phase 2 | Recruiting | University of Manitoba | 25 | 2021-10-20 | 2026-05-14 |
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Wounds and Injuries (13) · Cicatrix (7) · Pain (7) · Insulin Resistance (4) · Sunburn (4) · Wound Infection (4) · Ulcer (3) · Abscess (2) · Agnosia (2) · Anemia, Sickle Cell (2) · Anxiety Disorders (2) · Burns, Chemical (2) · Cellulitis (2) · Chronic Pain (2)
Wounds and Injuries (94) · Pathological Conditions, Signs and Symptoms (35) · Pathologic Processes (20) · Signs and Symptoms (16) · Neurologic Manifestations (13) · Skin and Connective Tissue Diseases (9) · Fibrosis (8) · Nervous System Diseases (8) · Skin Diseases (7) · Infections (6) · Glucose Metabolism Disorders (5) · Inflammation (5) · Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5)
Propranolol (6) · Metoprolol (4) · Fenofibrate (3) · Fentanyl (3) · Growth Hormone (3) · Saline Solution (3) · Cholecalciferol (2) · Dexmedetomidine (2) · Exercise (2) · Human Growth Hormone (2) · Itraconazole (2) · Metformin (2) · Nandrolone (2) · Oxandrolone (2) · Silver Sulfadiazine (2)
The University of Texas Medical Branch, Galveston (16) · Shriners Hospitals for Children (3) · University of North Carolina, Chapel Hill (3) · CUTISS AG (2) · Cephalon (2) · Cumberland Pharmaceuticals (2) · King Edward Medical University (2) · National Institute of General Medical Sciences (NIGMS) (2) · Noveome Biotherapeutics, formerly Stemnion (2) · Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara (2) · Stratatech, a Mallinckrodt Company (2) · Sun Yat-sen University (2) · TR Therapeutics (2) · University of Manitoba (2) · University of Texas Southwestern Medical Center (2)
United States (54) · Canada (9) · China (5) · France (3) · Switzerland (3) · Brazil (2) · Czechia (2) · Germany (2) · Iran (2) · Italy (2) · Netherlands (2) · Pakistan (2) · Puerto Rico (2) · Australia (1) · Belarus (1)
David N Herndon, MD (10) · Clemens Schiestl, Prof. (2) · David Herndon, MD (2) · G. Ralph Corey, MD (2) · John Joseph, MD (2) · Larry Jones, MD (2) · Alexey Chasnoit, Dr (1) · Alireza Baradaran Raffiee, MD (1) · Anatoliy V. Voronin (1) · Andrew L Blount, MD (1) · Anthony De Buys Roessingh (1) · Arnold Luterman, MD (1) · Aya A Bayoumy, MD (1) · Bernd Hartmann, MD (1)
PMID 17245174, PMID 22606232, PMID 39115183, PMID 11576045, PMID 15103422, PMID 16202520, PMID 16275600, PMID 16483293, PMID 17019126, PMID 18791359, PMID 19240154, PMID 19276766, PMID 19734776, PMID 20395554, PMID 20701787, PMID 20739853, PMID 20881067, PMID 21300053, PMID 21475006, PMID 21775883, PMID 21789167, PMID 22463890, PMID 22895351, PMID 23150682, PMID 23303450, PMID 23511841, PMID 23671631, PMID 23741350, PMID 24009246, PMID 24052307, PMID 24108222, PMID 24298851, PMID 24616577, PMID 24655871, PMID 24824900, PMID 24918945, PMID 25211297, PMID 25426401, PMID 25514427, PMID 25807408, PMID 26305798, PMID 26419871, PMID 26706649, PMID 27171844, PMID 27433905, PMID 28240622, PMID 29455032, PMID 31900475, PMID 34398099, PMID 35953455
P50GM060338 (2), K23AT011389 (1), P01NS119159 (1), R01GM042725 (1), R01GM056687 (1), R44AR047499 (1)