282 completed, 45 unknown, 43 terminated, 27 recruiting. 453 Phase 1, 128 Phase 2.
Follow Bone Diseases: new trials by email Literature Review of Bone Diseases trials Research Report on Bone Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Maxillary sinus floor elevation grafting with synthetic bone substitute. - Bone Loss, Osteoclastic, Bone Loss, Alveolar | Phase 1 | Not yet recruiting | Pontificia Universidade Católica do Rio Grande do Sul | 20 | 2027-12-15 | 2026-09-21 |
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-11-02 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-10-30 |
| Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease | Phase 1 | Not yet recruiting | Kolon TissueGene, Inc. | 24 | 2027-01-19 | 2026-08-20 |
| Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) Bone marrow-derived mesenchymal stromal cells (MSCs) - Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III | Phase 1 / Phase 2 | Not yet recruiting | Emory University | 12 | 2027-01-01 | 2026-05-08 |
| SCLife®-LDD hUC-MSCs Injection Therapy for Patients With Lumbar Intervertebral Disc Degeneration human umbilical cord mesenchymal stem cell suspension, total endoscopic extraction of lumbar nucleus pulposus - Lumbar Disc Degeneration | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 20 | 2026-12-31 | 2026-04-27 |
| The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH) Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression - Osteonecrosis of Femoral Head | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 30 | 2026-12-31 | 2026-04-23 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-11-30 | 2026-11-03 |
| Phase Ia Study of MST-931 in Healthy Adult Subjects MST-931, MST-931 Placebo - Ankylosing Spondylitis (AS) | Phase 1 | Recruiting | Mabsoft Therapeutics (Shanghai) Co., Ltd. | 32 | 2026-11-30 | 2026-11-03 |
| Comparing the Extent to Which Apremilast is Made Available in the Body After Administration as an Extended-release or Immediate-release Formulation Apremilast XR, Apremilast IR - Psoriasis, Arthritis, Psoriatic | Phase 1 | Not yet recruiting | Amgen | 114 | 2026-11-18 | 2026-11-02 |
| Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate. Alveolar Ridge Preservation using a synthetic alloplastic bone substitute and a resorbable polymer membrane, Minimally invasive flapless tooth extraction followed by unassisted spontaneous healing - Alveolar Ridge Augmentation, Bone Substitutes | Phase 1 / Phase 2 | Not yet recruiting | Universidad Católica San Antonio de Murcia | 28 | 2026-11-01 | 2026-10-16 |
| A Study of GKL-006Allo Injection in Patients With Ankylosing Spondylitis GKL-006Allo - Ankylosing Spondylitis | Phase 1 | Not yet recruiting | Beijing Gene Key Life Technology Co., Ltd | 12 | 2026-11-01 | 2026-11-04 |
| Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors. Dinutuximab beta, Sirolimus and Irinotecan - Osteosarcomas, Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 89 | 2026-10-01 | 2026-10-01 |
| A Study to Evaluate Pharmacokinetics of DRL_AB in Healthy Male Participants DRL_AB - Healthy Volunteers | Phase 1 | Not yet recruiting | Dr. Reddy's Laboratories Limited | 160 | 2026-08-19 | 2026-08-04 |
| Pharmacokinetics of Zoledronic Acid in Patients on Dialysis Zoledronic Acid Injection, 5.0 mg, single dose, Zoledronic Acid Injection, 2.5 mg, single dose - Chronic Kidney Disease, Osteoporosis | Phase 1 | Not yet recruiting | University of Campinas, Brazil | 24 | 2026-08-15 | 2026-09-10 |
| Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration High Dose, Low Dose - Disc Degenerative Disease, Back Pain | Phase 1 / Phase 2 | Not yet recruiting | Cartago Biotech Pty Ltd | 60 | 2026-07-04 | 2026-06-25 |
| Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females Blackcurrant (BC) extract, Placebo - Postmenopausal Osteoporosis, Gut Microbiome | Phase 1 | Recruiting | University of Connecticut | 159 | 2026-07-01 | 2026-07-23 |
| Safety and Efficacy of Allogeneic Bone Marrow MSCs in Ankylosing Spondylitis IV administration of CG-BM1, Placebo, CG-BM1 - Ankylosing Spondylitis | Phase 1 | Not yet recruiting | Eighth Affiliated Hospital, Sun Yat-sen University | 40 | 2026-07-01 | 2026-06-08 |
| A Phase 1 Study to Evaluate the Relative Bioavailability of Octreotide Acetate Tablets(T25) Compared to MYCAPSSA® and The Food Effect on Pharmacokinetics Of Octreotide Acetate Tablets(T25) T25-Fast, Mycapssa, T25-Fed - Acromegaly | Phase 1 | Completed | Triastek (Shanghai) Limited | 18 | 2026-06-25 | 2026-09-16 |
| Gene-Modified Stem Cell Therapy for Children With Autosomal Recessive Osteopetrosis (ARO) FT024 - Osteopetrosis | Phase 1 / Phase 2 | Recruiting | Fondazione Telethon | 8 | 2026-06-20 | 2026-06-24 |
Showing 20 of 453. Sign in to see all of them.
Osteoporosis (113) · Bone Neoplasms (39) · Arthritis, Psoriatic (31) · Bone Diseases, Metabolic (31) · Intervertebral Disc Degeneration (30) · Osteoporosis, Postmenopausal (24) · Spondylitis, Ankylosing (20) · Dwarfism, Pituitary (19) · Sarcoma (19) · Arthritis, Rheumatoid (16) · Neoplasms (15) · Alveolar Bone Loss (14) · Breast Neoplasms (14) · Camurati-Engelmann Syndrome (14) · Acromegaly (12)
Musculoskeletal Diseases (444) · Nutritional and Metabolic Diseases (174) · Metabolic Diseases (171) · Bone Diseases, Metabolic (130) · Spinal Diseases (103) · Bone Diseases, Developmental (83) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (79) · Neoplasms (71) · Skin and Connective Tissue Diseases (71) · Pathological Conditions, Signs and Symptoms (70) · Neoplasms by Site (66) · Joint Diseases (62) · Genetic Diseases, Inborn (58) · Arthritis (56)
Denosumab (11) · Human Growth Hormone (9) · romosozumab (9) · Cholecalciferol (8) · Teriparatide (8) · Calcium (6) · odanacatib (6) · Cyclophosphamide (5) · Vitamin D (5) · burosumab (5) · pembrolizumab (5) · somapacitan (5) · Alendronate (4) · Cisplatin (4) · Growth Hormone (4)
Amgen (13) · GlaxoSmithKline (11) · Merck Sharp & Dohme LLC (8) · Novo Nordisk A/S (6) · Baylor College of Medicine (5) · Eli Lilly and Company (5) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (5) · Kyowa Kirin Co., Ltd. (5) · M.D. Anderson Cancer Center (5) · National Cancer Institute (NCI) (5) · Novartis (5) · Bristol-Myers Squibb (4) · Children's Hospital Medical Center, Cincinnati (4) · Mayo Clinic (4) · National Taiwan University Hospital (4)
United States (203) · China (42) · Canada (23) · Spain (23) · Australia (22) · Germany (22) · France (20) · South Korea (16) · United Kingdom (15) · Italy (14) · Netherlands (14) · Japan (11) · Belgium (10) · Brazil (9) · Poland (9)
Hamid Gourabi, PhD (4) · Nasser Aghdami, MD,PhD (4) · Ahmad Vosough, MD (2) · Amol J. Ghia, MD (2)
PMID 31401903, PMID 21148044, PMID 23013236, PMID 25769789, PMID 25919461, PMID 29671202, PMID 31442616, PMID 33754315, PMID 40576086, PMID 10360702, PMID 10488513, PMID 11050032, PMID 11172169, PMID 12709856, PMID 15084121, PMID 15175591, PMID 15883634, PMID 16076940, PMID 16087995, PMID 16227895, PMID 17077737, PMID 17146025, PMID 17256032, PMID 17978354, PMID 18359949, PMID 18385391, PMID 18400730, PMID 18491071, PMID 19055791, PMID 19142567, PMID 19244376, PMID 19487105, PMID 19587341, PMID 19776051, PMID 19830485, PMID 19953837, PMID 20231202, PMID 20460997, PMID 20497785, PMID 20551965, PMID 20932341, PMID 20950166, PMID 20961422, PMID 21143878, PMID 21448918, PMID 21555774, PMID 21740089, PMID 21749263, PMID 21766228, PMID 21845241
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