7 completed, 4 recruiting, 4 unknown, 2 not yet recruiting. 5 Not applicable, 3 Phase 3, 2 Phase 2, 2 Phase 4, 1 Early Phase 1.
Follow Osteoradionecrosis: new trials by email Literature Review of Osteoradionecrosis trials Research Report on Osteoradionecrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy Osteoradionecrosis, Radiotherapy | Not yet recruiting | AO Innovation Translation Center | 1000 | 2027-03-01 | 2026-09-23 | |
| Platelet-Rich Fibrin for Preventing Osteoradionecrosis After Dental Extractions Platelet-rich fibrin (PRF), Standard Dental Extraction Care - Osteoradionecrosis of the Jaw | Not applicable | Not yet recruiting | University of Manitoba | 112 | 2027-01-01 | 2026-10-05 |
| Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible modified PENTOCLO (mPENTOCLO), sham mPENTOCLO - Osteoradionecrosis, Osteoradionecrosis of Jaw | Phase 3 | Recruiting | Sunnybrook Health Sciences Centre | 24 | 2025-01-16 | 2025-09-12 |
| Radiation Field, Dose and Fractionation Related to Mandibular Complications Radiotherapy - Head and Neck Neoplasms, Osteoradionecrosis | Unknown | Lund University Hospital | 120 | 2023-01-01 | 2024-05-23 | |
| Intensive Preventative Dental Program Pilot Study Fluoride varnish, Regular Care, Medical Oncology Care Team - Dental Diseases | Early Phase 1 | Completed | Wake Forest University Health Sciences | 13 | 2021-10-19 | 2025-11-03 |
| Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention Preventive, LLL Phototherapy and topical Vit E, Curative, LLL Phototherapy and topical Vit E, Preventive, LLL Phototherapy and LPRF - Oral Mucositis, Osteoradionecrosis | Not applicable | Completed | University of Santiago de Compostela | 60 | 2021-02-10 | 2023-11-29 |
| The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis. Hyperbaric oxygen treatment - Osteoradionecrosis | Not applicable | Unknown | Göteborg University | 120 | 2019-03-19 | 2021-06-22 |
| Risk for Subsequent Osteoradionecrosis in A Transferred Fibula Flap in Head and Neck Cancer Patients Undergoing Segmental Mandibulectomy: a Cohort Study Radiotherapy - Head and Neck Cancer, Fibula Flap | Completed | Chang Gung Memorial Hospital | 580 | 2019-03-01 | 2024-05-24 | |
| Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors Contrast Agent, Magnetic Resonance Imaging, Quality-of-Life Assessment - Malignant Oral Cavity Neoplasm, Malignant Skull Base Neoplasm | Phase 4 | Recruiting | M.D. Anderson Cancer Center | 425 | 2018-09-17 | 2026-05-22 |
| Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Questionnaire Administration - Head and Neck Cancer | Not applicable | Recruiting | M.D. Anderson Cancer Center | 1400 | 2017-03-21 | 2026-10-07 |
| Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment. Tooth extraction - Head and Neck Cancer, Osteoradionecrosis | Unknown | Catholic University of the Sacred Heart | 160 | 2017-03-14 | 2023-08-30 | |
| Management of Mandibular ORN: PENTO as Medical Treatment Pentoxifylline and Tocopherol - Osteoradionecrosis | Phase 4 | Completed | Hospital Vall d'Hebron | 24 | 2016-02-01 | 2018-03-22 |
| Saliva, Hyperbaric Oxygen Therapy, & Gland Function: A Prospective Study Osteoradionecrosis of the Jaw, Xerostomia | Withdrawn | Loma Linda University | 2015-08-01 | 2017-04-27 | ||
| Observational Study of Dental Outcomes in Head and Neck Cancer Patients Head and Neck Cancer, Dental Disease | Completed | Wake Forest University Health Sciences | 613 | 2014-02-01 | 2026-06-30 | |
| Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients Head and Neck Cancer, Dental Diseases | Completed | Wake Forest University Health Sciences | 202 | 2014-02-01 | 2026-06-29 | |
| Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw Reconstruction Head and Neck Cancer, Osteonecrosis | Recruiting | AZ Sint-Jan AV | 55 | 2013-06-01 | 2022-02-28 | |
| ORN Study: Curative Treatment of Osteoradionecrosis (ORN) With Hybrid Bone Substitution Hybrid bone substitution - Mandible, Osteoradionecrosis | Not applicable | Completed | Nantes University Hospital | 13 | 2009-11-18 | 2018-04-06 |
| Efficacy of Hyperbaric Oxygen Therapy in the Treatment of Osteoradionecrosis hyperbaric oxygen - Osteoradionecrosis | Phase 2 / Phase 3 | Terminated | Radboud University Medical Center | 20 | 2009-10-01 | 2025-09-15 |
| Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study Hyperbaric oxygen - Osteoradionecrosis | Phase 2 | Unknown | Lone Forner | 114 | 2008-06-01 | 2012-05-25 |
| Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Hyperbaric Oxygen Therapy, Sham treatment - Radiation Injuries | Phase 3 | Terminated | National Baromedical Services | 248 | 2001-01-01 | 2016-01-12 |
Head and Neck Neoplasms (10) · Mouth Neoplasms (3) · Radiation Injuries (3) · Stomatognathic Diseases (3) · Xerostomia (3) · Osteonecrosis (2) · Bisphosphonate-Associated Osteonecrosis of the Jaw (1) · Cystitis (1) · Dental Caries (1) · Enteritis (1) · Neoplasms (1) · Proctitis (1) · Stomatitis (1) · Tooth Avulsion (1)
Wounds and Injuries (19) · Radiation Injuries (17) · Neoplasms by Site (12) · Neoplasms (11) · Mouth Diseases (5) · Stomatognathic Diseases (5) · Bone Diseases (3) · Musculoskeletal Diseases (3) · Necrosis (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Salivary Gland Diseases (3) · Head and Neck Neoplasms (2) · Tooth Diseases (2) · Digestive System Diseases (1)
Hyperbaric Oxygenation (3) · Pentoxifylline (2) · Radiotherapy (2) · Tocopherols (2) · Clodronic Acid (1) · Contrast Media (1) · Magnetic Resonance Spectroscopy (1) · Tooth Extraction (1)
Wake Forest University Health Sciences (3) · M.D. Anderson Cancer Center (2) · AO Innovation Translation Center (1) · AZ Sint-Jan AV (1) · Catholic University of the Sacred Heart (1) · Chang Gung Memorial Hospital (1) · Göteborg University (1) · Hospital Vall d'Hebron (1) · Loma Linda University (1) · Lone Forner (1) · Lund University Hospital (1) · Nantes University Hospital (1) · National Baromedical Services (1) · Radboud University Medical Center (1) · Sunnybrook Health Sciences Centre (1)
United States (7) · Sweden (3) · Canada (2) · Spain (2) · Australia (1) · Belgium (1) · Denmark (1) · France (1) · Italy (1) · Mexico (1) · Netherlands (1) · South Africa (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Michael T Brennan, DDS, MHS (2) · Ben Safa, MD (1) · Dick Clarke, CHT (1) · Edmund Chan, DMD (1) · Francois Dieleman, MD DMD (1) · Hans Kaanders, MD PhD (1) · Johan Abeloos, MD (1) · Julia M Burgess, DMD (current OMFS Resident) (1) · Khalid Abdel-Galil, MD (1) · Lone Forner, DDS, PhD (1) · Martin Bengtsson, PhD (1) · Matthew C. Ward, MD (1) · Michael T. Brennan, DDS, MHS (1) · Miriam Martos-Fernandez, MD (1)
PMID 28241807, PMID 28675770, PMID 29173331, PMID 30891159, PMID 32451231, PMID 32991009, PMID 34242067, PMID 34665873, PMID 34879248, PMID 35231809, PMID 35304084, PMID 35403479, PMID 36230669, PMID 36717342, PMID 37079106, PMID 37236706, PMID 38262773, PMID 38456849, PMID 38591808, PMID 39005202, PMID 40784870, PMID 41290309, PMID 41327109, PMID 41781851
U01DE022939 (2)