Tuberculosis, Pulmonary: Clinical Trials

172 completed, 57 unknown, 35 recruiting, 18 not yet recruiting. 91 Phase 2, 63 Not applicable, 45 Phase 3, 27 Phase 1, 15 Phase 4.

By phase and status

Phase	Trials	Status
Phase 2	91	Completed 58, Recruiting 13, Unknown 6, Not yet recruiting 5, Active not recruiting 3, Suspended 2, Terminated 2, Withdrawn 2
Not applicable	63	Completed 37, Unknown 14, Recruiting 5, Terminated 2, Withdrawn 2, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1
Phase 3	45	Completed 22, Recruiting 9, Not yet recruiting 5, Unknown 4, Active not recruiting 3, Terminated 1, Withdrawn 1
Phase 1	27	Completed 20, Unknown 3, Withdrawn 2, Recruiting 1, Terminated 1
Phase 4	15	Unknown 8, Completed 4, Not yet recruiting 1, Recruiting 1, Terminated 1
Early Phase 1	2	Not yet recruiting 1, Recruiting 1

Follow Tuberculosis, Pulmonary: new trials by email Literature Review of Tuberculosis, Pulmonary trials Research Report on Tuberculosis, Pulmonary

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB ID93 + GLA-SE vaccine, Placebo vaccine - Tuberculosis, Pulmonary	Phase 2	Not yet recruiting	Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections	1500	2027-01-31	2026-08-24
The LalelaLung Study: Digital Stethoscope Clinical Evaluation StethoMe AI-enabled digital stethoscope system, Standard IMCI assessment - Pneumonia, Tuberculosis, Pulmonary	Phase 4	Not yet recruiting	Johns Hopkins University	350	2026-12-07	2026-11-10
A Trial of Stratified Patient-Centered Treatment Regimens for Active TB (SPECTRA-TB) Isoniazid, Rifampin, Pyrazinamide - Tuberculosis	Phase 2	Not yet recruiting	National Institute of Allergy and Infectious Diseases (NIAID)	900	2026-10-30	2026-08-19
Plasma MTB cfDNA Before Bronchoscopy Diagnostic Test: Plasma MTB cfDNA assay - Tuberculosis Diagnosis		Not yet recruiting	Chinese University of Hong Kong	600	2026-10-01	2025-11-17
Study of Combinations of Novel Promising Drugs for Pulmonary Tuberculosis TBAJ-587 50 mg, Pretomanid 200mg, Linezolid 600Mg Tab - Tuberculosis, Pulmonary	Phase 2	Not yet recruiting	TASK Applied Science	135	2026-09-25	2026-09-25
Fibroblast Activating Protein (FAP) PET/CT in Adults With Tuberculosis [18F]-FAPI-74 - Tuberculosis, Pulmonary	Early Phase 1	Recruiting	University of Pennsylvania	10	2026-09-22	2026-11-10
A Step Forward for Unraveling the Immune Mechanisms and Tools for Tuberculosis Spectrum Management Tuberculosis		Not yet recruiting	Irene Latorre Rueda	940	2026-09-01	2026-07-30
AIPH-TB: AI-Optimised Pyrazinamide-Hydroxychloroquine vs Standard RIPE for Drug-Sensitive Pulmonary Tuberculosis - A Phase II RCT Pyrazinamide and Hydroxychloroquine (AI-Optimised), Standard RIPE Regimen (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) - Pulmonary Tuberculosis	Phase 2	Not yet recruiting	Ministry of Health, Saudi Arabia	200	2026-09-01	2026-03-12
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial Omega-3 (EPA+DHA), Placebo - Tuberculosis, Inflammation Biomarkers	Phase 2	Recruiting	North-West University, South Africa	40	2026-08-19	2026-09-09
Effectiveness of Psychosocial Counseling in Patients With a New Tuberculosis Diagnosis psychosocial counseling - Pulmonary Tuberculosis, Treatment Adherence	Not applicable	Not yet recruiting	Universitas Diponegoro	108	2026-08-19	2026-07-14
Channa Striata and Curcuma Domestica Supplementation in Patients With Active Pulmonary Tuberculosis CHANA STRIATA AND CURCUMA, Maltodextrin (Placebo) - Pulmonary Tuberculosis	Not applicable	Recruiting	DINA KEUMALA SARI	80	2026-08-01	2026-10-21
Sorfequiline-based Regimens in Adults With Newly Diagnosed Drug-sensitive Pulmonary TB sorfequiline, Pretomanid, Linezolid - Tuberculosis, Pulmonary	Phase 2	Recruiting	Global Alliance for TB Drug Development	100	2026-07-09	2026-08-19
BRIGHT-Child TB: Short-Course Treatment for Non-Severe Pulmonary Tuberculosis in Children 4-month FDC-based regimen, 3-month BDCZ regimen, Standard 6-month treatment regimen - Tuberculosis	Phase 2	Recruiting	Huashan Hospital	90	2026-07-08	2026-10-26
Effect of Vitamin D and Zinc Supplementation on Inflammatory Biomarkers in Pulmonary Tuberculosis Patients Vitamin D (Cholecalciferol ), Zinc (zinc sulphate) - Pulmonary Tuberculosis	Not applicable	Completed	Hasanuddin University	32	2026-06-03	2026-10-27
Artificial Intelligence-driven Tuberculosis Landscape Analysis & Stratification Research Pulmonary Tuberculosis, Tuberculosis (TB)		Not yet recruiting	Huashan Hospital	31600	2026-06-01	2026-05-28
Digital Health Intervention to Improve TPT Uptake Digital health intervention - Tuberculosis, Pulmonary	Not applicable	Recruiting	Arba Minch University	304	2026-05-22	2026-09-25
Evaluating Urine Isoniazid Testing to Detect Nonadherence to Tuberculosis Medications in India Urine isoniazid testing (IsoScreen test) - Tuberculosis, Pulmonary, Medication Adherence	Not applicable	Enrolling by invitation	Tufts University	900	2026-04-07	2026-06-04
Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure) 8 week (short arm) Intervention - pulmonary rehabilitation, 24 week (long arm) Intervention - pulmonary rehabilitation - TB - Tuberculosis, TB	Not applicable	Recruiting	Johns Hopkins University	690	2026-03-18	2026-03-27
18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) in Tuberculosis Patients 18F-FAPI-74 - Tuberculosis, Pulmonary		Recruiting	Children's Hospital Medical Center, Cincinnati	30	2026-03-12	2026-03-31
Remimazolam for Bronchoscopy in High-Risk Patients propofol and alfentanil, remimazolam combined with propofol and alfentanil - Pulmonary Infection, Pulmonary Nodule	Phase 4	Recruiting	First Affiliated Hospital of Zhejiang University	360	2026-02-09	2026-02-24

Showing 20 of 311. Sign in to see all of them.

Narrower conditions

Tuberculosis (128)  ·  Tuberculosis, Multidrug-Resistant (29)  ·  Latent Tuberculosis (12)  ·  HIV Infections (11)  ·  Extensively Drug-Resistant Tuberculosis (10)  ·  Acquired Immunodeficiency Syndrome (9)  ·  Mycobacterium Infections (8)  ·  Disease (7)  ·  Lung Diseases (7)  ·  Lung Neoplasms (7)  ·  Pulmonary Disease, Chronic Obstructive (7)  ·  Bacterial Infections (6)  ·  COVID-19 (6)  ·  Tuberculosis, Extrapulmonary (6)

Broader conditions

Actinomycetales Infections (311)  ·  Bacterial Infections and Mycoses (311)  ·  Respiratory Tract Diseases (310)  ·  Infections (309)  ·  Gram-Positive Bacterial Infections (308)  ·  Respiratory Tract Infections (307)  ·  Bacterial Infections (305)  ·  Lung Diseases (304)  ·  Mycobacterium Infections (303)  ·  Tuberculosis (183)  ·  Pathological Conditions, Signs and Symptoms (28)  ·  Pathologic Processes (23)  ·  Virus Diseases (23)  ·  RNA Virus Infections (22)  ·  Immune System Diseases (19)

Interventions

Rifampin (53)  ·  Isoniazid (49)  ·  Pyrazinamide (47)  ·  Ethambutol (40)  ·  bedaquiline (33)  ·  Moxifloxacin (29)  ·  Linezolid (23)  ·  pretomanid (23)  ·  OPC-67683 (18)  ·  Clofazimine (12)  ·  Protons (10)  ·  Levofloxacin (9)  ·  rifapentine (9)  ·  2-(2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (7)  ·  Cholecalciferol (7)

Sponsors

Global Alliance for TB Drug Development (22)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (15)  ·  Michael Hoelscher (9)  ·  Johns Hopkins University (7)  ·  Beijing Chest Hospital (6)  ·  Seoul National University Hospital (6)  ·  Foundation for Innovative New Diagnostics, Switzerland (5)  ·  Huashan Hospital (5)  ·  National University Hospital, Singapore (5)  ·  TASK Applied Science (5)  ·  Access to Advanced Health Institute (AAHI) (4)  ·  Assistance Publique - Hôpitaux de Paris (4)  ·  Assiut University (4)  ·  Centers for Disease Control and Prevention (4)  ·  Tuberculosis Research Centre, India (4)

Countries

South Africa (73)  ·  China (27)  ·  India (26)  ·  United States (26)  ·  Uganda (24)  ·  Tanzania (17)  ·  South Korea (16)  ·  Brazil (13)  ·  Indonesia (13)  ·  Peru (13)  ·  Philippines (13)  ·  Pakistan (12)  ·  Georgia (9)  ·  Vietnam (9)  ·  Ethiopia (8)

Top investigators

Andreas Diacon, MD (5)  ·  Nicholas Paton (5)  ·  Rodney Dawson, MD (5)  ·  Susan Dorman, MD (5)  ·  Antonio Lombardi, MD (3)  ·  Bolanle A Omotoso, MD (3)  ·  Kelly Dooley, MD (3)  ·  Anatoly I Saulin, Master (2)  ·  Andreas Diacon (2)  ·  Bindu Dey, Ph.D. (2)  ·  Carole Mitnick, Sc.D (2)  ·  Clifton E Barry, Ph.D. (2)  ·  Cristina Vilaplana, MD, PhD (2)

Results publications

PMID 33616229, PMID 36808186, PMID 21215445, PMID 24675585, PMID 33542052, PMID 36053506, PMID 36546625, PMID 37980911, PMID 38768617, PMID 40067046, PMID 11009160, PMID 11401954, PMID 11682541, PMID 12507953, PMID 15141729, PMID 15374844, PMID 15746302, PMID 16466066, PMID 16675781, PMID 16898366, PMID 17084741, PMID 17159896, PMID 17574096, PMID 17624822, PMID 17705950, PMID 17712405, PMID 18173355, PMID 18245055, PMID 18647985, PMID 19383198, PMID 19416361, PMID 19424460, PMID 19555526, PMID 19864480, PMID 19880906, PMID 20174642, PMID 20504986, PMID 20610636, PMID 20656559, PMID 20720033, PMID 20825313, PMID 21030451, PMID 21393153, PMID 21956689, PMID 22260950, PMID 22430968, PMID 22670901, PMID 22828481, PMID 22850121, PMID 22936710

NIH funding

2005 (1), 2019 (1), 272201400041C-0-0-1 (1), R01AI104824 (1), R01AI152142 (1), R01AI169588 (1), R01HL130192 (1), R01HL138728 (1), R21AI161301 (1), R21AI192087 (1), R21EB023679 (1), R33HD109804 (1), R43EB028736 (1), U01AI068636 (1), U01AI134585 (1)