8 completed, 6 recruiting, 3 unknown, 2 not yet recruiting. 6 Not applicable, 4 Phase 4, 2 Phase 1, 2 Phase 3, 1 Phase 2.
Follow Atherosclerotic Plaque: new trials by email Literature Review of Atherosclerotic Plaque trials Research Report on Atherosclerotic Plaque
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma Evolocumab, Routine Lipid Management, Autoinjector - Coronary Artery Disease, Hypercholesterolemia | Phase 4 | Not yet recruiting | Amgen | 308 | 2027-01-31 | 2026-09-21 |
| PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke Recaticimab plus standard therapy, Recaticimab's placebo in combination with standard therapy - Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 1212 | 2026-09-01 | 2026-07-15 |
| PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis Recaticimab and Statin, Statin - Intracranial Atherosclerosis, Intracranial Artery Stenosis | Phase 4 | Recruiting | Peking Union Medical College Hospital | 300 | 2025-11-07 | 2026-06-12 |
| Fish Oil, Metformin and Heart Health in PCOS Fish oil, Metformin, Fish Oil and Metformin - PCOS, Cardiovascular Disease | Phase 1 | Recruiting | University of Alberta | 146 | 2025-11-01 | 2025-12-12 |
| Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT Rosuvastatin 40mg, Placebo, Coronary Computed Tomography Angiography (Coronary CTA) - Coronary Artery Disease, Atherosclerotic Plaque | Not applicable | Recruiting | Prof. Maurovich-Horvat Pál | 140 | 2025-05-28 | 2026-05-13 |
| Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS) Alirocumab, Atorvastatin - Intracranial Atherosclerosis, Atherosclerotic Plaque | Phase 3 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 80 | 2023-12-30 | 2023-12-21 |
| Whole Blood Transcriptomic Signal According to Coronary Atherosclerotic Plaque Burden Assessed by CT Angiography Calcific Coronary Arteriosclerosis, Coronary Stenosis | Enrolling by invitation | MultiplAI Health Limited | 200 | 2023-09-19 | 2024-01-08 | |
| Efficacy and Safety of Intravascular High-pressure Cutting Balloon Catheters for PCI PCI - Atherosclerotic Plaque | Not applicable | Completed | BrosMed Medical Co., Ltd | 168 | 2023-06-16 | 2025-06-06 |
| Pakistan Study of Premature Coronary Atherosclerosis in Young Adults Atherosclerotic Plaque, Diabetes Mellitus, Type 2 | Recruiting | Tabba Heart Institute | 2000 | 2023-03-15 | 2023-04-07 | |
| Detection of Coronary Artery Calcifications by Whole Blood Transcriptome Analyzed by Artificial InTelligence Algorithms Atherosclerosis, Atheroscleroses, Coronary | Completed | Santiago Gabriel Miriuka | 800 | 2022-11-07 | 2024-03-20 | |
| STabilization of Atheroma by Lipid-reducing Effect of Drug-Coated Balloon (STABLE-DCB) SeQuent Please Neo - Coronary Artery Disease, Atherosclerotic Plaque | Recruiting | Korea University Ansan Hospital | 65 | 2022-10-13 | 2024-10-15 | |
| First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI Dual-modal OCT-FLIm - Atherosclerosis Coronary Artery With Angina Pectoris, Atheroscleroses, Coronary | Not applicable | Completed | Korea University Guro Hospital | 40 | 2022-02-14 | 2023-12-04 |
| Digital Secondary Prevention in Cardiovascular Disease PreventiPlaque App - Atherosclerotic Plaque | Not applicable | Unknown | University Hospital, Essen | 240 | 2021-11-01 | 2021-10-27 |
| Coronary Artery Geometry and the Severity of Coronary Atherosclerosis CCTA - Coronary Artery Disease, Atherosclerosis | Unknown | Aristotle University Of Thessaloniki | 100 | 2020-06-04 | 2020-06-05 | |
| 99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques 99mTc-Annexin-V-128 uptake on scintigraphy - Carotid Atherosclerosis, Atherosclerotic Plaque | Phase 2 / Phase 3 | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2018-09-01 | 2021-10-20 | |
| Long-term Follow-up NIRS-IVUS Imaging of Pre-existing Carotid Stents Near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS) - Carotid Atherosclerosis, Carotid Artery Stenting | Not applicable | Completed | University Hospital, Motol | 52 | 2017-07-15 | 2020-04-29 |
| Reduced Radiation Dose and IR-impact on Coronary Calcium Quantification Iterative reconstruction at reduced radiation dose - Atherosclerotic Plaque | Not applicable | Terminated | University of Pennsylvania | 190 | 2017-07-01 | 2024-03-07 |
| 18F-fluoride (18F-NaF) PET for Identifying Coronary Atherosclerotic Plaques 18F-NaF PET and coronary CTA imaging - Coronary Artery Disease, Atherosclerotic Plaque | Phase 4 | Completed | Cedars-Sinai Medical Center | 41 | 2015-11-13 | 2022-07-22 |
| Diagnosis of Macrophage Coronary Plaque by Optical Tomographic Imaging The heart subject will undergo OCT - Atherosclerotic Plaque | Completed | Young-Hak Kim, MD, PhD | 20 | 2015-05-12 | 2018-09-06 | |
| Molecular Mechanisms and Carotid Atherosclerosis statin Oral Tablet plus PCSK9i - Diabetes Mellitus, Type 2, Atherosclerosis of Artery | Completed | University of Campania Luigi Vanvitelli | 76 | 2015-01-01 | 2022-08-03 |
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Plaque, Atherosclerotic (22) · Atherosclerosis (7) · Coronary Artery Disease (7) · Cardiovascular Diseases (4) · Intracranial Arteriosclerosis (3) · Carotid Artery Diseases (2) · Diabetes Mellitus, Type 2 (2) · Inflammation (2) · Angina, Stable (1) · Arteriosclerosis (1) · Cardiomegaly (1) · Carotid Stenosis (1) · Constriction, Pathologic (1) · Coronary Stenosis (1) · Heart Diseases (1)
Pathological Conditions, Anatomical (22) · Pathological Conditions, Signs and Symptoms (22) · Vascular Diseases (16) · Arterial Occlusive Diseases (14) · Arteriosclerosis (13) · Cardiovascular Diseases (13) · Coronary Disease (8) · Heart Diseases (8) · Myocardial Ischemia (8) · Brain Diseases (7) · Central Nervous System Diseases (7) · Cerebrovascular Disorders (7) · Nervous System Diseases (7) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4)
Hydroxymethylglutaryl-CoA Reductase Inhibitors (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Atorvastatin (1) · Clinical Laboratory Techniques (1) · Fish Oils (1) · Hematologic Tests (1) · Indocyanine Green (1) · Metformin (1) · Observation (1) · Rosuvastatin Calcium (1) · Sodium Fluoride (1) · Spectroscopy, Near-Infrared (1) · Standard of Care (1) · alirocumab (1) · evolocumab (1)
Peking Union Medical College Hospital (2) · Amgen (1) · Aristotle University Of Thessaloniki (1) · Assistance Publique - Hôpitaux de Paris (1) · BrosMed Medical Co., Ltd (1) · Cedars-Sinai Medical Center (1) · Korea University Ansan Hospital (1) · Korea University Guro Hospital (1) · Lund University (1) · Massachusetts General Hospital (1) · MultiplAI Health Limited (1) · Prof. Maurovich-Horvat Pál (1) · Santiago Gabriel Miriuka (1) · Tabba Heart Institute (1) · The First Affiliated Hospital with Nanjing Medical University (1)
China (4) · South Korea (3) · United States (3) · Argentina (2) · Canada (1) · Czechia (1) · Greece (1) · Hungary (1) · Italy (1) · Pakistan (1) · Sweden (1)
Sunwon Kim, MD, PhD (2) · Daniel S. Berman (1) · Dong Oh Kang, MD, PhD (1) · Farouc A Jaffer, MD PhD (1) · Georgios Rampidis, MD, MSc (1) · Haralambos Karvounis, MD, PhD (1) · Hongki Yoo, PhD (1) · Isabel Goncalves, MD, PhD (1) · Jin Won Kim, MD, PhD (1) · Kezhong Zhang, MD (1) · Konstantinos Kouskouras, MD, PhD (1) · Marc Dewey, Prof., Dr. (1)
PMID 28304224, PMID 17548554, PMID 17548555, PMID 21899409, PMID 24489130, PMID 27544892, PMID 27846344, PMID 30066942, PMID 31011477, PMID 31707788, PMID 31886149, PMID 32561535, PMID 32817184, PMID 34353533, PMID 35048716, PMID 35070788, PMID 35143758, PMID 35943472, PMID 37009731, PMID 37738517, PMID 37984941, PMID 38048667, PMID 38212060, PMID 38648030, PMID 38817546, PMID 39087353, PMID 39182330, PMID 39387764, PMID 39505412, PMID 39548030, PMID 39755915, PMID 39818872, PMID 39843925, PMID 40616232, PMID 40820974, PMID 41107765, PMID 41389830, PMID 41500725, PMID 41582814, PMID 42262770, PMID 42760081
2017 (1), 2025 (1)