17 completed, 15 recruiting, 7 not yet recruiting, 1 active not recruiting. 20 Not applicable, 9 Phase 1, 3 Early Phase 1, 3 Phase 2, 1 Phase 4.
Follow Alzheimer's Disease (AD): new trials by email Literature Review of Alzheimer's Disease (AD) trials Research Report on Alzheimer's Disease (AD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improv Music Therapy for Older Adults Clinical Improvisation - Alzheimer's Disease (AD), Older Adults (65 Years and Older) | Not applicable | Not yet recruiting | University of California, San Francisco | 40 | 2026-12-01 | 2026-02-23 |
| Negotiation Training for Family Caregivers of People With Alzheimer's Disease NegotiAge, PlanYourLifespan - Alzheimer's Disease (AD), Dementia | Not applicable | Not yet recruiting | Northwestern University | 200 | 2026-11-01 | 2026-10-05 |
| CMN LIFU for Enhanced Glymphatic Clearance in Amyloid-Positive MCI ATTN201 Focused Ultrasound to the CMN, ATTN201 Unfocused Ultrasound - Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | University of California, San Francisco | 28 | 2026-10-01 | 2026-10-14 |
| The Effect of Urolithin A (Mitopure®) on Alzheimer's Disease Urolithin A, Placebo Control - Alzheimer's Disease (AD), Early Alzheimer's Disease | Not applicable | Recruiting | University Hospital, Akershus | 60 | 2026-09-26 | 2026-10-08 |
| Phase 1 Study to Evaluate the Safety and Tolerability of 8M2D in Healthy People and Alzheimer's Patients 8M2D, Placebo - Alzheimer's Disease (AD) | Phase 1 | Not yet recruiting | Cenna Biosciences Inc. | 54 | 2026-09-15 | 2026-05-05 |
| Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement Personalized optimal gamma auditory frequency stimulation, Non-optimal gamma auditory frequency stimulation - Gamma Oscillations, Healthy Adults | Not applicable | Not yet recruiting | Chang Gung Memorial Hospital | 20 | 2026-08-01 | 2026-07-16 |
| Blood-based Biomarkers for Alzheimer's Disease at the Primary Care Level. ptau217 - Alzheimer's Disease (AD) | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 240 | 2026-05-26 | 2026-06-24 |
| Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease blood sampling - Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 48 | 2026-05-18 | 2026-09-03 |
| Improvement of Sleep Disorders in Patients With Alzheimer's Disease After Sunlight Exposure Therapy. sunlight therapy - Alzheimer's Disease (AD), Sleep Disorders, Circadian Rhythm | Not applicable | Active not recruiting | National Taiwan University Hospital | 60 | 2026-05-13 | 2026-07-17 |
| Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI Plase-Locked Acoustic Stimulation during slow-wave sleep, Phase-locked acoustic stimulation-Sham condition - Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic | Not applicable | Not yet recruiting | Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida) | 114 | 2026-04-01 | 2026-04-14 |
| Adapting RDAD for DS Remote Exercise Sessions, Caregiver Education Sessions - Down Syndrome (DS), Alzheimer's Disease (AD) | Not applicable | Recruiting | University of Kansas Medical Center | 40 | 2026-03-31 | 2026-08-03 |
| Prospective Single-Arm Safety Study of Cervical LVA in AD Patients Supermicrosurgical Lymphaticovenular Anastomosis (LVA) - Alzheimer's Disease (AD) | Phase 1 | Not yet recruiting | Chang Gung Memorial Hospital | 35 | 2026-03-01 | 2026-03-09 |
| Social-cognitive Functioning: Validation of a New Neuropsychological Test REALSOCOG, BCS, Hetero-questionnaires - Alzheimer's Disease (AD), Lewy Body Dementia (LBD) | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2026-02-04 | 2026-03-13 |
| Contribution of Pathological Alpha-synuclein as a Diagnostic Biomarker for Dementia With Lewy Bodies Biological : blood sampling, nasopharyngeal swab, Procedure : Lumbar puncture - Dementia With Lewy Bodies (DLB), Alzheimer's Disease (AD) | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 286 | 2026-01-01 | 2025-09-10 |
| Evaluation of a Neuropsychological Tool to Assess Temporal Processing Abilities in Alzheimer's Disease Chronos battery - Alzheimer's Disease (AD), Time Perception | Recruiting | University Hospital, Caen | 40 | 2025-12-30 | 2026-03-19 | |
| Biofluid Research on Age-Related or Inherited Neurodegeneration Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis) | Recruiting | University of Pennsylvania | 1000 | 2025-12-12 | 2026-09-01 | |
| The BRidge Towards Implementation of Blood-based Biomarkers to Enable Early and Accurate Diagnosis of Alzheimer's Disease Plasma p-tau217 and neurofilament light chain results - Alzheimer Blood Biomarkers, Alzheimer's Disease (AD) | Not applicable | Recruiting | Alzheimercentrum Amsterdam | 550 | 2025-09-17 | 2026-07-02 |
| Evaluation of SCALE PET Software for Quantitative Brain PET Analysis in Alzheimer's Disease Neurophet SCALE PET - Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) | Not applicable | Completed | NEUROPHET | 190 | 2025-06-02 | 2026-02-18 |
| COGSCREEN II: Early Detection of Cognitive Impairment Early Detection - Alzheimer's Disease (AD) | Not applicable | Recruiting | Robert Perneczky | 400 | 2025-06-01 | 2026-03-12 |
| Exploring the Utility of [18F]3F4AP for Demyelination Imaging [ 18F]3F4AP, [18F]MK6240, [11C]PIB - Demyelinating Disorders, MCI | Phase 1 | Recruiting | Yale University | 105 | 2025-05-05 | 2026-09-09 |
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Alzheimer Disease (43) · Cognitive Dysfunction (12) · Dementia (9) · Plaque, Amyloid (6) · Neurodegenerative Diseases (4) · Amyotrophic Lateral Sclerosis (3) · Cognition Disorders (3) · Lewy Body Disease (3) · Parkinson Disease (3) · Pick Disease of the Brain (3) · Supranuclear Palsy, Progressive (3) · Frontotemporal Dementia (2) · Aphasia, Primary Progressive (1) · Caregiver Burden (1) · Chronic Traumatic Encephalopathy (1)
Brain Diseases (43) · Central Nervous System Diseases (43) · Mental Disorders (43) · Nervous System Diseases (43) · Neurocognitive Disorders (43) · Tauopathies (42) · Neurodegenerative Diseases (39) · Dementia (34) · Pathological Conditions, Signs and Symptoms (10) · Cognition Disorders (9) · Basal Ganglia Diseases (6) · Pathological Conditions, Anatomical (6) · Frontotemporal Lobar Degeneration (5) · Movement Disorders (5) · Parkinsonian Disorders (5)
7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (3) · florbetapir (3) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (2) · Magnetic Resonance Spectroscopy (2) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one (1) · Blood Specimen Collection (1) · Donepezil (1) · Exercise Test (1) · Functional Status (1) · Lorazepam (1) · Memantine (1) · Neuropsychological Tests (1) · Oxaloacetic Acid (1) · Sodium Chloride (1)
Molecular NeuroImaging (3) · University of Southern California (3) · AbbVie (2) · Chang Gung Memorial Hospital (2) · Universitaire Ziekenhuizen KU Leuven (2) · University of California, San Francisco (2) · AC Immune SA (1) · Alzheimercentrum Amsterdam (1) · Amoneta Diagnostics SAS (1) · Assistance Publique - Hôpitaux de Paris (1) · Atridia Pty Ltd. (1) · Cenna Biosciences Inc. (1) · Chong Kun Dang Pharmaceutical (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · HealthPartners Institute (1)
United States (18) · France (5) · Germany (3) · Taiwan (3) · Australia (2) · Belgium (2) · Canada (2) · Netherlands (2) · South Korea (2) · Spain (2) · China (1) · Czechia (1) · Israel (1) · Italy (1) · Japan (1)
Danna Jennings, MD (3) · Michael W. Weiner, MD (2) · Paul Aisen, MD (2) · Amy Bodde, PhD (1) · Andrew Krystal, MD (1) · Corey McMillan, PhD (1) · Cynthia Stonnington, MD (1) · Donald R. Royall, MD (1) · Elsmarieke van de Giessen, MD (1) · Eric Guedj, Prof. (1) · Evandro Fei Fang-Stavem, PhD (1)
PMID 34187867, PMID 38853879, PMID 39219209, PMID 39324520, PMID 42862762, PMID 27908967, PMID 29107051, PMID 33719017, PMID 33773598, PMID 42348024, PMID 42565245
U01AG024904 (2), 2015 (1), 2017 (1), 2023 (1), K01AG088475 (1), KL2TR002367 (1), P01AG066597 (1), P30AG072979 (1), P41EB022544 (1), R01AG054029 (1), R01AG076153 (1), R01AG080548 (1), R01AG085561 (1), R01EB033582 (1), R56AG068421 (1)