Altitude Sickness: Clinical Trials

22 completed, 3 unknown, 2 terminated, 1 not yet recruiting. 29 Phase 4.

By phase and status

Phase	Trials	Status
Phase 4	29	Completed 22, Unknown 3, Terminated 2, Not yet recruiting 1, Recruiting 1

Follow Altitude Sickness: new trials by email Literature Review of Altitude Sickness trials Research Report on Altitude Sickness

Trials (filtered) newest first · largest first

All 29 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo - Acute Mountain Sickness	Phase 4	Not yet recruiting	Insel Gruppe AG, University Hospital Bern	30	2027-06-01	2026-07-01
HighCycle Study: Acetazolamide, High Altitude and Plasma Volume Acetazolamide, Placebo - High Altitude Effects, High Altitude Hypoxia	Phase 4	Recruiting	Centre d'Expertise sur l'Altitude EXALT	270	2024-07-15	2025-08-12
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men Acetazolamide, Placebo - Acute Mountain Sickness	Phase 4	Completed	University of Zurich	303	2024-07-15	2026-01-23
HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men Acetazolamide, Placebo - High Altitude	Phase 4	Completed	University of Zurich	303	2024-07-15	2026-06-05
Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance Acetazolamide 250Mg Tab, Methazolamide Pill, Placebo - High Altitude Effects	Phase 4	Completed	University of Waterloo	15	2023-08-11	2024-03-12
Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude Pioglitazone 15mg, Placebo - High Altitude	Phase 4	Completed	United States Army Research Institute of Environmental Medicine	9	2023-03-01	2026-03-19
Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide Acetazolamide, Doctormate® (twice daily for 6 days), Doctormate® (forth daily for 3 days) - Acute Mountain Sickness	Phase 4	Completed	Ji Xunming,MD,PhD	252	2021-12-01	2022-10-03
Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness Immediate descent from altitude., Diphenhydramine, Prochlorperazine 10 mg - AMS, Acute Mountain Sickness	Phase 4	Completed	CHRISTUS Health	30	2021-05-20	2024-05-28
Colorado-Oregon Altitude Study Erythropoietin, Iron sucrose (Venofer), Sterile Sodium Chloride - Acute Mountain Sickness	Phase 4	Completed	University of Oregon	121	2021-02-17	2023-03-10
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude. ACETAZOLAMIDE oral capsule, Placebo oral capsule - Altitude Hypoxia	Phase 4	Unknown	University of Zurich	400	2018-06-01	2023-03-10
Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude ACETAZOLAMIDE oral capsule, Placebo oral capsule - Altitude Hypoxia	Phase 4	Unknown	University of Zurich	100	2018-06-01	2022-11-02
Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude ACETAZOLAMIDE oral capsule, Placebo oral capsule - Altitude Hypoxia	Phase 4	Unknown	University of Zurich	100	2018-06-01	2022-11-02
Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude ACETAZOLAMIDE oral capsule, Placebo oral capsule - Altitude Hypoxia	Phase 4	Completed	University of Zurich	185	2018-05-15	2021-11-05
Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude ACETAZOLAMIDE oral capsule, Placebo oral capsule - Altitude Hypoxia	Phase 4	Completed	University of Zurich	59	2018-05-15	2021-10-12
Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years ACETAZOLAMIDE oral capsule, Placebo oral capsule - Acute Mountain Sickness	Phase 4	Completed	University of Zurich	349	2018-05-15	2021-05-13
Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude ACETAZOLAMIDE oral capsule, Placebo oral capsule - Altitude Hypoxia	Phase 4	Completed	University of Zurich	99	2018-05-15	2021-10-12
Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude ACETAZOLAMIDE oral capsule, Placebo oral capsule - Altitude Hypoxia	Phase 4	Completed	University of Zurich	92	2018-05-15	2021-10-12
Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography Acetazolamide, Placebo - High Altitude Pulmonary Edema	Phase 4	Terminated	Vincent Kan	18	2018-03-23	2019-05-10
Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia Cetirizine, Placebo oral capsule, Hypoxia - Hypoxia, Altitude	Phase 4	Completed	Indiana University	13	2017-08-31	2020-06-16
AZ, MZ, and the Pulmonary System Response to Hypoxia Acetazolamide, Methazolamide, Placebo - Altitude Sickness, Hypertension, Pulmonary	Phase 4	Completed	University of British Columbia	14	2016-05-01	2016-10-19

Showing 20 of 29. Sign in to see all of them.

Narrower conditions

Hypoxia (5)  ·  Hypertension, Pulmonary (3)  ·  Motor Activity (2)  ·  Headache (1)  ·  Hypertension (1)  ·  Hypoventilation (1)  ·  Migraine Disorders (1)  ·  Polycythemia (1)  ·  Pulmonary edema of mountaineers (1)  ·  Respiratory Aspiration (1)  ·  Sleep Apnea Syndromes (1)

Broader conditions

Respiration Disorders (29)  ·  Respiratory Tract Diseases (29)  ·  Pathological Conditions, Signs and Symptoms (6)  ·  Signs and Symptoms (6)  ·  Signs and Symptoms, Respiratory (5)  ·  Cardiovascular Diseases (4)  ·  Vascular Diseases (4)  ·  Hypertension (3)  ·  Lung Diseases (3)  ·  Behavior (2)  ·  Nervous System Diseases (2)  ·  Apnea (1)  ·  Brain Diseases (1)  ·  Central Nervous System Diseases (1)  ·  Dyssomnias (1)

Interventions

Acetazolamide (17)  ·  Methazolamide (3)  ·  Erythropoietin (2)  ·  Acetaminophen (1)  ·  Altitude (1)  ·  Cetirizine (1)  ·  Diphenhydramine (1)  ·  Ferric Oxide, Saccharated (1)  ·  Ibuprofen (1)  ·  Metformin (1)  ·  Nifedipine (1)  ·  Nitrites (1)  ·  Pioglitazone (1)  ·  Prochlorperazine (1)  ·  Quercetin (1)

Sponsors

University of Zurich (10)  ·  United States Army Research Institute of Environmental Medicine (2)  ·  Altitude Physiology Expeditions (1)  ·  Association pour la Recherche en Physiologie de l'Environnement (1)  ·  CHRISTUS Health (1)  ·  Centre d'Expertise sur l'Altitude EXALT (1)  ·  Indiana University (1)  ·  Insel Gruppe AG, University Hospital Bern (1)  ·  Istituto Auxologico Italiano (1)  ·  Ji Xunming,MD,PhD (1)  ·  Mountain Medicine Society of Nepal (1)  ·  Oxford University Clinical Research Unit, Vietnam (1)  ·  Richard Moon (1)  ·  University of British Columbia (1)  ·  University of Colorado, Denver (1)

Countries

Kyrgyzstan (11)  ·  United States (8)  ·  Canada (2)  ·  Nepal (2)  ·  Peru (2)  ·  China (1)  ·  South Korea (1)  ·  Switzerland (1)

Top investigators

Konrad E Bloch, MD (8)  ·  Michael Furian, MSc (7)  ·  Talant M Sooronbaev, MD (6)  ·  Silvia Ulrich, MD (3)  ·  Michael Furian, Prof. Dr. (2)  ·  Talant M Sooronbaev,, MD (2)  ·  Talant Sooronbaev, Prof. Dr. (2)  ·  Benoit Champigneulle, MD, PhD (1)  ·  Buddha Basnyat, MD (1)  ·  Buddha Basnyat, MD PhD (1)  ·  Charles S Fulco, ScD (1)  ·  Fabiola Leon-Velarde, PHD (1)  ·  Gianfranco Parati, MD, PhD (1)  ·  Glen E Foster, Ph.D. (1)  ·  Hillary Irons, MD, PhD (1)

Results publications

PMID 18388356, PMID 18719057, PMID 21962063, PMID 23098412, PMID 23270443, PMID 24616593, PMID 25895588, PMID 29886423, PMID 36356042, PMID 36662903, PMID 38166913, PMID 38250659, PMID 38296630, PMID 39778901, PMID 40878988