6 completed, 2 terminated, 1 unknown. 4 Phase 2, 2 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Nitrites: new trials by email Literature Review of Nitrites trials Research Report on Nitrites
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nutritional Supplementation and Insulin Sensitivity L-arginine + Nitrate / Nitrite, Placebo - Nitric Oxide, Insulin Sensitivity | Not applicable | Terminated | Maastricht University Medical Center | 1 | 2020-09-01 | 2021-06-11 |
| Nutritional Supplements and Nitric Oxide Bioactivity L-Arginine, Nitrate / Nitrite, Placebo - Nitric Oxide, Vascular Function | Not applicable | Completed | Maastricht University Medical Center | 20 | 2018-12-01 | 2020-02-20 |
| Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction sodium nitrite, Control - Heart Failure | Phase 2 | Completed | Gladwin, Mark, MD | 15 | 2017-04-03 | 2020-01-22 |
| Haemodynamic Effects of Dobutamine and Nitrite in LV Dysfunction Dobutamine, Nitrite - Heart Failure | Unknown | King's College London | 45 | 2016-10-01 | 2016-09-05 | |
| Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in Heart Failure With Preserved Ejection Fraction (HFpEF) (INABLE-Training) Placebo, Sodium Nitrite, Accelerometer - Heart Failure | Phase 2 | Completed | Barry Borlaug | 92 | 2016-09-01 | 2023-04-26 |
| Three New Ideas to Protect Special Forces From the Stress of High Altitude Quercetin, Nifedipine extended release, Methazolamide - Mountain Sickness | Phase 4 | Completed | University of Colorado, Denver | 148 | 2015-08-01 | 2021-03-30 |
| Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction Nitrite, Saline Placebo for Nitrite - Heart Disease, Heart Failure With Preserved Ejection Fraction | Phase 2 | Completed | Barry Borlaug | 28 | 2013-08-01 | 2016-03-14 |
| A Phase 2 Study to Determine the Safety and Efficacy of AIR001 in Subjects With Pulmonary Arterial Hypertension (PAH) AIR001 (sodium nitrite inhalation solution) - Pulmonary Arterial Hypertension | Phase 2 | Terminated | Aires Pharmaceuticals, Inc. | 29 | 2012-11-01 | 2014-04-09 |
| Pilot Study of Sodium Nitrite in Resuscitated Cardiac Arrest Patients nitrite - Cardiac Arrest | Phase 1 | Completed | University of Washington | 11 | 2010-01-01 | 2017-05-18 |
Heart Failure (3) · Altitude Sickness (1) · Heart Arrest (1) · Heart Diseases (1) · Hypertension, Pulmonary (1) · Insulin Resistance (1) · Motor Activity (1) · Pulmonary Arterial Hypertension (1) · Ventricular Fibrillation (1)
Barry Borlaug (2) · Maastricht University Medical Center (2) · Aires Pharmaceuticals, Inc. (1) · Gladwin, Mark, MD (1) · King's College London (1) · University of Colorado, Denver (1) · University of Washington (1)
United States (6) · Netherlands (2) · Australia (1) · Hungary (1) · United Kingdom (1)
Peter J Joris, PhD (2) · Adaani E Frost, M.D. (1) · Barry A Borlaug, MD (1) · Barry Borlaug, MD (1) · Daniel E Forman, MD (1) · Francis Kim, MD (1) · Robert Roach, PhD (1)
PMID 26449137, PMID 33421267, PMID 37565977, PMID 38127015
R01HL128526 (1), R56AG051637 (1)