20 completed, 8 unknown, 3 recruiting, 3 terminated. 17 Not applicable, 9 Phase 2, 4 Phase 3, 4 Phase 4, 2 Phase 1.
Follow Alcohol Withdrawal: new trials by email Literature Review of Alcohol Withdrawal trials Research Report on Alcohol Withdrawal
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients Sodium Acetate, Placebo - Alcohol Withdrawal, Alcohol Abstinence | Phase 1 / Phase 2 | Not yet recruiting | University of Colorado, Denver | 75 | 2026-11-01 | 2026-10-30 |
| Comparison of the Effect on Anxiety of Combining Hypnosis and Aromatherapy Through Olfactory Anchoring Versus Standard Care in Patients Undergoing Alcohol Withdrawal Usual treatment, Experimental treatment - Alcohol Withdrawal, Anxiety | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 80 | 2026-03-01 | 2026-03-06 |
| Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,, magnetic resonance imaging session, Placebo beverage - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 30 | 2025-08-01 | 2025-09-15 |
| Use of tAN® in Alcohol Withdrawal Management Transcutaneous Auricular Neurostimulation (tAN) - Alcohol Withdrawal | Not applicable | Terminated | Erin Takemoto | 12 | 2025-04-21 | 2026-08-05 |
| Motivational Interviews Post Hospitalisation on Maintaining AbstiNence for 1 Year après le Sevrage en Alcool Experimental group : PSH (usual care) with motivational interviewing - Alcohol Use Disorder, Addiction | Not applicable | Recruiting | University Hospital, Montpellier | 104 | 2024-12-18 | 2026-06-18 |
| Validation of the French Version of the Prediction of the Alcohol Withdrawal Severity Scale (PAWSS) French version PAWSS - Addiction, Substance, Alcohol Use Disorder | Recruiting | Etablissement Public de Santé Barthélemy Durand | 545 | 2024-11-11 | 2025-02-25 | |
| Effects of Ketone Supplementation on Acute Alcohol Withdrawal Kenetik; Ketone Concentrate, Isocaloric dextrose placebo - Alcohol Use Disorder, Alcohol Withdrawal | Phase 2 / Phase 3 | Enrolling by invitation | University of Pennsylvania | 50 | 2024-03-11 | 2026-04-06 |
| Using Transcutaneous Auricular Vagus Nerve Stimulation to Treat Acute Alcohol Withdrawal Transcutaneous Nerve Stimulation, Sham Stimulation - Alcohol Withdrawal, Alcohol Use Disorder | Not applicable | Withdrawn | Northwell Health | 2024-01-31 | 2024-03-13 | |
| Study of Exploratory Plasmatic Markers of Alcohol Withdrawal Alcohol Withdrawal | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 28 | 2023-04-19 | 2026-09-23 | |
| Safety & Efficacy of Baclofen for Alcohol Withdrawal in Chronic Liver Disease With Active Alcohol Consumption Baclofen - Alcoholic Cirrhosis, Alcohol Abstinence | Enrolling by invitation | Corporacion Parc Tauli | 120 | 2022-12-22 | 2025-02-21 | |
| Bright Light Therapy During Residential Alcohol Withdrawal Light exposure, Placebo light - Alcohol Use Disorder, Alcohol Withdrawal | Not applicable | Unknown | Centre Hospitalier St Anne | 100 | 2022-05-31 | 2025-03-14 |
| Metabolism of Chlordiazepoxide in the Treatment of Alcohol Withdrawal Symptoms Blood samples - Alcohol Withdrawal | Completed | University Hospital Bispebjerg and Frederiksberg | 26 | 2022-01-29 | 2024-05-07 | |
| Riboflavin for Glutamate Reduction in Alcohol Withdrawal Riboflavin, Placebo - Alcohol Withdrawal, Nutrition Disorders | Phase 2 | Unknown | Oregon Health and Science University | 40 | 2021-12-01 | 2021-09-29 |
| Digitally Assisted Recovery Coach Digitally assisted peer recovery coach - Alcohol Use Disorder, Alcohol Withdrawal | Not applicable | Completed | Brigham and Women's Hospital | 10 | 2021-11-01 | 2022-05-26 |
| Remote Treatment of Alcohol Withdrawal Diazepam - Alcohol Withdrawal | Not applicable | Completed | Centre for Addiction and Mental Health | 30 | 2021-09-24 | 2026-05-14 |
| Evaluation of Bilateral HF-rTMS on Abstinence in Alcohol Use Disorder Patients With Executive Dysfunction Active rTMS, Sham rTMS - Alcohol Withdrawal | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 95 | 2021-09-01 | 2021-08-30 |
| Prazosin for Alcohol Use Disorder With Withdrawal Symptoms Prazosin, 12-Step Facilitation with Relapse Prevention and Contingency Management - Alcohol Withdrawal | Phase 2 | Completed | Yale University | 152 | 2021-07-01 | 2026-09-30 |
| Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome Phenobarbital Sodium, Inactive placebo - Alcohol Withdrawal Delirium, Alcohol Withdrawal | Not applicable | Terminated | Unity Health Toronto | 8 | 2021-06-11 | 2023-11-02 |
| Impact of COVID-19 Outbreak on the Alcohol Consumption in Patients With Alcohol-related Liver Disease (ICoLD) Study questionnaire - Alcohol-related Liver Disease, Alcohol Dependence | Unknown | King's College Hospital NHS Trust | 200 | 2020-10-08 | 2021-05-10 | |
| Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit Phenobarbital, Lorazepam - Alcohol Withdrawal, Alcohol Withdrawal Delirium | Phase 4 | Unknown | OSF Healthcare System | 142 | 2020-07-06 | 2020-10-08 |
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Alcoholism (22) · Alcohol Abstinence (3) · Behavior, Addictive (3) · Ketosis (3) · Substance-Related Disorders (3) · Alcohol Drinking (2) · Alcohol Withdrawal Delirium (2) · Acidosis, Lactic (1) · Alcohol Withdrawal Seizures (1) · Alcohol-Related Disorders (1) · Alcoholic Intoxication (1) · Anxiety Disorders (1) · Beriberi (1) · Cocaine-Related Disorders (1) · Drug-Related Side Effects and Adverse Reactions (1)
Chemically-Induced Disorders (28) · Mental Disorders (28) · Alcohol-Related Disorders (26) · Substance-Related Disorders (25) · Behavior (8) · Nutritional and Metabolic Diseases (5) · Acid-Base Imbalance (4) · Acidosis (4) · Drinking Behavior (4) · Metabolic Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Alcohol-Induced Disorders (3) · Compulsive Behavior (3) · Impulsive Behavior (3) · Nervous System Diseases (3)
Diazepam (4) · Baclofen (3) · Phenobarbital (3) · Chlordiazepoxide (2) · Gabapentin (2) · Lorazepam (2) · Saline Solution (2) · Blood Specimen Collection (1) · Cannabidiol (1) · Control Groups (1) · Dexmedetomidine (1) · Ketamine (1) · Ketones (1) · Magnesium Sulfate (1) · Motivational Interviewing (1)
University of Colorado, Denver (3) · Centre Hospitalier Intercommunal Creteil (2) · University of North Carolina, Chapel Hill (2) · University of Pennsylvania (2) · Anders Fink-Jensen, MD, DMSci (1) · Assistance Publique - Hôpitaux de Paris (1) · Brigham and Women's Hospital (1) · Centre Hospitalier Esquirol (1) · Centre Hospitalier St Anne (1) · Centre for Addiction and Mental Health (1) · Corporacion Parc Tauli (1) · Erin Takemoto (1) · Essentia Health (1) · Etablissement Public de Santé Barthélemy Durand (1) · Glasgow Royal Infirmary (1)
United States (18) · France (9) · Denmark (3) · Canada (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Spain (1)
Alain Dervaux (1) · Anders Fink-Jensen, MD, DMSc (1) · Andrew C Chen, MD, PhD (1) · Bhagat Aulakh, MD (1) · Brandon Cornejo, MD, PhD (1) · Brenda A Miller, Ph.D. (1) · Christopher J Stock, PharmD (1) · Corinde E Wiers, Ph.D. (1) · Corinde Wiers, Ph.D. (1) · Cort A Pedersem, M.D. (1) · Cort A Pedersen, M.D. (1) · David Fiellin, MD (1) · Donogh Maguire, MB BCh (1)
PMID 19560604, PMID 22898443, PMID 23780805, PMID 29172702, PMID 30146330, PMID 30640504, PMID 32150232, PMID 33410985, PMID 34128818, PMID 34256607, PMID 35065662, PMID 35484175, PMID 37405844, PMID 37635913, PMID 38828963, PMID 42070965
R01AA029113 (1), R21AA031337 (1)