34 completed, 19 unknown, 17 recruiting, 11 terminated. 24 Not applicable, 22 Phase 2, 10 Phase 1, 9 Phase 3, 4 Phase 4.
Follow Adenomatous Polyposis Coli: new trials by email Literature Review of Adenomatous Polyposis Coli trials Research Report on Adenomatous Polyposis Coli
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis Rapamycin - Familial Adenomatous Polyposis | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 25 | 2026-09-01 | 2026-05-08 |
| Evaluation of the Ileo-anal Pouch in FAP (ENDOPOL) Chromoendoscopy (Indigo Carmine), Virtual Chromoendoscopy - Familial Adenomatous Polyposis (FAP), Pouches, Ileoanal | Not applicable | Recruiting | London North West Healthcare NHS Trust | 50 | 2026-07-09 | 2026-07-24 |
| Trial of Exercise Therapy in Familial Adenomatous Polyp (FAP) Exercise Therapy - Familial Adenomatous Polyposis | Not applicable | Recruiting | University of Michigan Rogel Cancer Center | 32 | 2026-05-13 | 2026-05-19 |
| An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis Biopsy Procedure, Biospecimen Collection, EP2/EP4 Antagonist TPST-1495 - Colorectal Carcinoma, Familial Adenomatous Polyposis | Phase 2 | Recruiting | National Cancer Institute (NCI) | 38 | 2026-03-31 | 2026-09-14 |
| Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion preoperative stoma identification and education - Colorectal Anastomosis, Endometrial | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 100 | 2026-03-01 | 2025-11-18 |
| Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma Tegavivint - Metastatic Colorectal Carcinoma (mCRC), Colorectal Cancer (CRC) | Phase 1 / Phase 2 | Recruiting | HonorHealth Research Institute | 126 | 2026-02-17 | 2026-03-11 |
| Testing for Safety and Colorectal Cancer Preventive Effects of ONC201 Biopsy Procedure, Biospecimen Collection, Colonoscopy - Colorectal Adenomatous Polyp, Colorectal Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2025-10-06 | 2026-10-15 |
| Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis eRapa (encapsulated rapamycin), Placebo - Familial Adenomatous Polyposis (FAP) | Phase 3 | Recruiting | Rapamycin Holdings Inc. | 168 | 2025-07-18 | 2026-06-02 |
| Ten Versus Fifteen Centimeter Pouch in IPAA Surgery 10 cm pouch, 15 cm pouch - Ulcerative Colitis, Familial Adenomatous Polyposis | Not applicable | Recruiting | Odense University Hospital | 120 | 2025-07-03 | 2025-07-09 |
| Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions Colonoscopy - Colorectal Cancer (CRC), Adenomatous Polyposis | Not applicable | Recruiting | Instituto do Cancer do Estado de São Paulo | 1000 | 2025-02-01 | 2026-06-23 |
| Microbial and Environmental Factors Associated With Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP) Sampling of feces and duodenal fluids - Familial Adenomatous Polyposis | Recruiting | Hospices Civils de Lyon | 100 | 2024-12-17 | 2026-05-27 | |
| Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis R-1,3-Butanediol (10G-A), R-1,3-Butanediol (20G-A), R-1,3-Butanediol (30G-A) - FAP, Familial Adenomatous Polyposis | Not applicable | Enrolling by invitation | Abramson Cancer Center at Penn Medicine | 20 | 2024-09-20 | 2026-09-16 |
| Detection of Ileoanal Pouch/Reservoir Adenomas Adenomas detection rate with the different observation methods - Adenomatous Polyps | Unknown | Jean Christophe Saurin | 40 | 2024-09-09 | 2023-09-25 | |
| Chemopreventive Effect of Combination of Celecoxib and Metformin in Patients With Familial Adenomatous Polyposis celecoxib monotherapy, celecoxib and metformin combination - Familial Adenomatous Polyposis | Phase 3 | Unknown | Yonsei University | 28 | 2024-08-13 | 2024-08-09 |
| Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare) Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP) | Active not recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 1500 | 2024-05-13 | 2026-03-10 | |
| Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients. Vitamin B1 - Familial Adenomatous Polyposis (FAP) | Not applicable | Enrolling by invitation | Shanghai Zhongshan Hospital | 10 | 2024-01-08 | 2026-04-24 |
| Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis low energy argonplasma coagulation - Adenomatous Polyposis Coli, Familial Adenomatous Polyposis | Not applicable | Unknown | Universitätsklinikum Hamburg-Eppendorf | 10 | 2023-12-06 | 2024-05-30 |
| Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP) REC-4881, Placebo - Familial Adenomatous Polyposis | Phase 1 / Phase 2 | Recruiting | Recursion Pharmaceuticals Inc. | 67 | 2023-07-10 | 2026-06-05 |
| FOG-001 in Locally Advanced or Metastatic Solid Tumors FOG-001, mFOLFOX-6, Nivolumab - Cancer, Colorectal Cancer | Phase 1 / Phase 2 | Recruiting | Parabilis Medicines, Inc. | 619 | 2023-05-23 | 2026-10-07 |
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Colorectal Neoplasms (20) · Colitis, Ulcerative (11) · Colorectal Neoplasms, Hereditary Nonpolyposis (7) · Polyps (7) · Adenoma (6) · Crohn Disease (5) · Desmoid Tumors (5) · Duodenal Neoplasms (5) · Colonic Neoplasms (4) · Rectal Neoplasms (4) · Adenomatous Polyps (3) · Anastomotic Leak (3) · Attenuated familial adenomatous polyposis (3) · Gastrointestinal Neoplasms (3)
Colonic Diseases (93) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (93) · Intestinal Polyposis (93) · Neoplasms by Histologic Type (93) · Neoplasms by Site (93) · Neoplasms, Glandular and Epithelial (93) · Digestive System Diseases (92) · Digestive System Neoplasms (92) · Gastrointestinal Diseases (92) · Intestinal Diseases (92) · Intestinal Neoplasms (92) · Genetic Diseases, Inborn (91) · Neoplastic Syndromes, Hereditary (91) · Adenomatous Polyps (90) · Gastrointestinal Neoplasms (90)
Celecoxib (7) · Biopsy (5) · Sulindac (4) · Curcumin (3) · Eflornithine (3) · Endoscopy (3) · Sirolimus (3) · Specimen Handling (3) · Colonoscopy (2) · Endoscopy, Digestive System (2) · Endoscopy, Gastrointestinal (2) · Erlotinib Hydrochloride (2) · Erythromycin (2) · Gastroscopy (2) · Sigmoidoscopy (2)
National Cancer Institute (NCI) (8) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (4) · Charite University, Berlin, Germany (3) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (3) · Janssen Research & Development, LLC (3) · M.D. Anderson Cancer Center (3) · Yonsei University (3) · Cancer Prevention Pharmaceuticals, Inc. (2) · Johns Hopkins University (2) · London North West Healthcare NHS Trust (2) · Radboud University Medical Center (2) · Rapamycin Holdings Inc. (2) · S.L.A. Pharma AG (2) · Tel-Aviv Sourasky Medical Center (2) · Vanderbilt University Medical Center (2)
United States (39) · Netherlands (11) · Germany (8) · Puerto Rico (8) · France (7) · Italy (6) · Spain (6) · United Kingdom (6) · Denmark (5) · Israel (4) · South Korea (4) · Belgium (3) · China (3) · Sweden (3) · Australia (2)
Niloy J Samadder (3) · Gary Shangold, MD (2) · Marco Vitellaro, MD (2) · Revital Kariv, MD (2) · Alexander G Raufi, MD (1) · Alfred M. Cohen, M.D. (1) · Andre Latchford, MBBS PhD FRCP (1) · Angela George (1) · Anthony J Senagore, MD, MBA, MS (1) · Arthur F Stucchi, PhD (1) · Ashish Patel, MD (1) · Benjamin Oshrine (1)
PMID 37119510, PMID 29802852, PMID 20018966, PMID 20234350, PMID 20348368, PMID 21899713, PMID 23114473, PMID 23919274, PMID 24245549, PMID 25792707, PMID 26528500, PMID 27002448, PMID 29423501, PMID 30012100, PMID 31898110, PMID 32905675, PMID 33376109, PMID 33509804, PMID 34253565, PMID 34261858, PMID 35477756, PMID 35636921, PMID 35962368, PMID 37201686, PMID 38422953, PMID 39956770
N01CN00042 (2), P30CA015083 (2), P30CA016672 (2), P30CA068485 (2), UG1CA242632 (2), 2019 (1), 2023 (1), P01CA073992 (1), P30CA006973 (1), P30CA014520 (1), P30CA046592 (1), R01CA106577 (1), R01CA134620 (1), R41CA126453 (1), UG1CA242596 (1)