32 completed, 14 recruiting, 7 active not recruiting, 5 unknown. 23 Phase 2, 14 Phase 1, 9 Not applicable, 5 Phase 3, 1 Early Phase 1.
Follow Desmoid Tumors: new trials by email Literature Review of Desmoid Tumors trials Research Report on Desmoid Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Patient-reported Outcomes Following Percutaneous Ablation of Desmoid Tumors Desmoid tumor ablation - Desmoid Tumor, Aggressive Fibromatoses | Enrolling by invitation | Mayo Clinic | 30 | 2026-10-01 | 2026-09-29 | |
| A Study in Adults With Desmoid Tumors ES014 - Desmoid Tumor | Phase 2 | Recruiting | Elpiscience (Suzhou) Biopharma, Ltd. | 50 | 2026-04-24 | 2026-10-21 |
| Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) Nirogacestat - Desmoid Tumor, Aggressive Fibromatosis | Phase 4 | Recruiting | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 50 | 2025-09-17 | 2026-10-13 |
| A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) Nirogacestat oral tablet - Desmoid Tumor, Aggressive Fibromatosis | Phase 2 | Active not recruiting | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany | 20 | 2025-08-08 | 2026-09-15 |
| Treatment of Desmoid Fibromatosis With Arterial Embolization embolization therapy - Desmoid Fibromatosis | Recruiting | Istituto Ortopedico Rizzoli | 20 | 2025-07-01 | 2025-09-12 | |
| Immunological Phenotype of Desmoid-fibromatosis-affected Patients. Desmoid-Type Fibromatosis | Recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 200 | 2025-05-27 | 2026-03-27 | |
| Electrochemotherapy for Desmoid Tumors Electrochemotherapy with bleomycin - Desmoid Fibromatosis | Withdrawn | Istituto Ortopedico Rizzoli | 2024-10-17 | 2026-05-14 | ||
| PRISM for Depression and Anxiety in Young Adults With Cancer Promoting Resilience in Stress Management Program - Cancer Diagnosis, Non-Metastatic Neoplasm | Not applicable | Completed | Dana-Farber Cancer Institute | 13 | 2024-09-06 | 2026-04-21 |
| Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare) Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP) | Active not recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 1500 | 2024-05-13 | 2026-03-10 | |
| A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors radiofrequency ablation - Desmoid Tumor, Desmoid Fibromatosis | Not applicable | Not yet recruiting | Blokhin's Russian Cancer Research Center | 27 | 2024-04-01 | 2024-04-10 |
| Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting Cryoablation, Chemotherapy drug - Desmoid Tumor | Not applicable | Recruiting | University Hospital, Strasbourg, France | 150 | 2024-03-04 | 2025-11-19 |
| Radiomics Compared With Conventional Response Criteria for Predicting Progression of Desmoid Tumor After Cryoablation Cryoablation - Desmoid | Recruiting | Istituto Ortopedico Rizzoli | 21 | 2024-02-20 | 2026-05-12 | |
| Arterial Chemoembolization for the Treatment of Desmoid Fibromatosis Chemoembolization with Doxorubicin - Desmoid | Recruiting | Istituto Ortopedico Rizzoli | 20 | 2024-02-20 | 2026-05-14 | |
| Burden of Disease and Living Situation in Desmoid Patients No Intervention - Desmoid Tumor, Quality of Life | Completed | Technische Universität Dresden | 100 | 2023-10-01 | 2025-08-24 | |
| Study of Cryoablation and Nirogacestat for Desmoid Tumor Nirogacestat, Cryoablation - Desmoid Tumor | Phase 2 | Recruiting | Nam Bui | 28 | 2023-08-15 | 2026-09-10 |
| FOG-001 in Locally Advanced or Metastatic Solid Tumors FOG-001, mFOLFOX-6, Nivolumab - Cancer, Colorectal Cancer | Phase 1 / Phase 2 | Recruiting | Parabilis Medicines, Inc. | 619 | 2023-05-23 | 2026-10-07 |
| Clinical Study of Anlotinib Combined With Chemotherapy in the Treatment of Unresectable Advanced Desmoid Tumor Anlotinib - Desmoid | Not applicable | Unknown | Henan Cancer Hospital | 30 | 2022-08-20 | 2023-10-30 |
| Desmoid Tumor and Pregnancy: Effect of Pregnancy on Disease Control and Effect of Diagnosis on Pregnancy History. Pregnancy - Desmoid, Desmoid; Abdominal | Unknown | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 400 | 2022-03-01 | 2023-01-27 | |
| HIFU Ablation of Soft Tissue Sarcoma High Intensity Focused Ultrasound Ablation, Tumour Biopsy and Venous Blood Tests - Soft Tissue Sarcoma, Desmoid Tumors | Not applicable | Recruiting | Oxford University Hospitals NHS Trust | 10 | 2021-12-10 | 2026-02-04 |
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Sarcoma (9) · Neoplasms (8) · Carcinoma, Hepatocellular (7) · Colorectal Neoplasms (6) · Endometrial Neoplasms (6) · Osteosarcoma (6) · Chordoma (5) · Melanoma (5) · Sarcoma, Ewing (5) · Adenomatous Polyposis Coli (4) · Adrenocortical Carcinoma (4) · Desmoplastic Small Round Cell Tumor (4) · Fibroma (4) · Rhabdomyosarcoma (4)
Neoplasms by Histologic Type (67) · Neoplasms, Connective Tissue (67) · Neoplasms, Connective and Soft Tissue (67) · Neoplasms, Fibrous Tissue (67) · Fibroma (63) · Neoplasms (59) · Neoplasms by Site (17) · Neoplasms, Glandular and Epithelial (16) · Digestive System Diseases (15) · Digestive System Neoplasms (13) · Gastrointestinal Diseases (13) · Gastrointestinal Neoplasms (12) · Neoplasms, Germ Cell and Embryonal (12) · Female Urogenital Diseases and Pregnancy Complications (11) · Intestinal Diseases (11)
nirogacestat (8) · Cryosurgery (3) · Imatinib Mesylate (3) · Magnetic Resonance Spectroscopy (3) · Nivolumab (3) · Specimen Handling (3) · Blood Specimen Collection (2) · Phantoms, Imaging (2) · Toremifene (2) · X-Rays (2) · 4-hydroxy-N-desmethyltamoxifen (1) · Abdominoplasty (1) · Absorptiometry, Photon (1) · Albumin-Bound Paclitaxel (1) · Bevacizumab (1)
Children's Oncology Group (7) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (5) · Istituto Ortopedico Rizzoli (5) · National Cancer Institute (NCI) (4) · SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany (4) · University Hospital, Strasbourg, France (3) · Centre Oscar Lambret (2) · Memorial Sloan Kettering Cancer Center (2) · Abramson Cancer Center at Penn Medicine (1) · Advocate Lutheran General Hospital (1) · AeRang Kim (1) · Blokhin's Russian Cancer Research Center (1) · Children's Hospital of Philadelphia (1) · Dana-Farber Cancer Institute (1) · Eisai Co., Ltd. (1)
United States (33) · Italy (13) · Canada (8) · France (8) · Germany (7) · Netherlands (7) · Australia (6) · United Kingdom (6) · Belgium (4) · China (4) · New Zealand (3) · Puerto Rico (3) · Spain (3) · Israel (2) · Japan (2)
Steve Skapek, MD (2) · Aaron R Weiss, DO (1) · AeRang Kim, MD, PhD (1) · Aimee M Crago, MD, PhD (1) · Alessandro Gronchi, MD (1) · Alice P Chen, M.D. (1) · Ashish Patel, MD (1) · Benjamin Oshrine (1) · Bernd Kasper, MD (1) · Bernd Kasper, PD Dr. med. (1)
PMID 31401903, PMID 17290057, PMID 19451429, PMID 19768644, PMID 20622000, PMID 22480131, PMID 23114473, PMID 24089446, PMID 26602014, PMID 26861905, PMID 27020837, PMID 27064168, PMID 28282612, PMID 28350521, PMID 30575484, PMID 31236956, PMID 31969335, PMID 33258687, PMID 33290994, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34420143, PMID 34716198, PMID 35247923, PMID 35294527, PMID 36884323, PMID 37347393, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39856213, PMID 39956770, PMID 40402690, PMID 40588371, PMID 41115259, PMID 41672597, PMID 41720620, PMID 41892875, PMID 41903360, PMID 41995270, PMID 42499790
U10CA098543 (2), 2008 (1), 2016 (1), P30CA008748 (1), P30CA068485 (1), U10CA024507 (1), U10CA031946 (1), U10CA180821 (1), U10CA180886 (1), U10CA180888 (1), UG1CA189958 (1), UM1CA228823 (1)