15 completed, 6 unknown, 5 recruiting, 2 withdrawn. 9 Not applicable, 5 Phase 3, 3 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 8, Recruiting 1 |
| Phase 3 | 5 | Unknown 4, Recruiting 1 |
| Phase 4 | 3 | Completed 2, Terminated 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Hypertensive Crisis: new trials by email Literature Review of Hypertensive Crisis trials Research Report on Hypertensive Crisis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension Tonlamarsen, Placebo - Hypertension, Acute Severe Hypertension | Phase 2 | Recruiting | Kardigan, Inc. | 140 | 2026-06-23 | 2026-10-15 |
| Determinants of Malignant Hypertension Onset and Related Target Organ Damages: the HAMA Biobank biobank - Malignant Hypertension | Recruiting | Centre Hospitalier de PAU | 1000 | 2026-03-19 | 2026-10-22 | |
| Nicardipine vs. Labetalol nicardipine intravenous, labetalol intravenous - Acute Ischemic Stroke, Hypertensive Crisis | Phase 4 | Completed | Haseki Training and Research Hospital | 34 | 2025-02-01 | 2025-12-11 |
| Optic Nerve Sheath Diameter in Hypertensive Emergency Optic Nerve Sheath Diameter - Hypertensive Emergency, Papilledema | Not yet recruiting | Leiden University Medical Center | 375 | 2024-11-01 | 2024-10-09 | |
| HYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP Hypertensive Urgency, Weather | Recruiting | Saglik Bilimleri Universitesi | 350 | 2024-09-15 | 2024-10-10 | |
| The Use of Virtual Reality and Music Therapy for Hypertensive Urgency Captopril 25Mg Tab, Virtual Reality Exposure, Classic Music Therapy - Hypertensive Urgency, Primary Hypertension | Not applicable | Completed | Ankara City Hospital Bilkent | 130 | 2024-08-01 | 2026-05-07 |
| The Value of TOI in Evaluating Renal Function Damage in Hypertensive Emergency Patients The relationship between TOI composite index and renal function in hypertensive emergency patients was compared - Hypertensive Emergency | Unknown | The Affiliated Hospital of Hangzhou Normal University | 300 | 2024-02-01 | 2024-01-22 | |
| Eculizumab in Hypertensive Emergency-associated Hemolytic Uremic Syndrome Soliris®, Renin angiotensin system blockers - Hypertensive Emergency-associated Hemolytic Uremic Syndrome | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 66 | 2023-11-09 | 2024-01-05 |
| a Study Evaluating the Safety and Efficacy of Clevidipine for Patients Who With Hypertensive Emergency and Sub-emergency QLG2071, Cleviprex® - Hypertensive Emergency | Phase 3 | Unknown | Qilu Pharmaceutical (Hainan) Co., Ltd. | 378 | 2023-07-15 | 2023-06-28 |
| A Study of Clevidipine Butyrate Injectable Emulsion in the Treatment of Hypertensive Emergency and Sub-emergency Clevidipine Butyrate Injectable Emulsion, Cleviprex® - Hypertensive Emergency | Phase 3 | Unknown | CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. | 398 | 2023-05-01 | 2023-03-24 |
| Postpartum Hypertension Study Labetalol, Nifedipine - Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia | Phase 4 | Terminated | Columbia University | 2 | 2022-07-04 | 2026-05-06 |
| Rural Hospital-Level Care at Home for Acutely Ill Adults Home Hospital care, Traditional Hospital care - Infections, Heart Failure | Not applicable | Completed | Brigham and Women's Hospital | 160 | 2022-02-16 | 2025-11-12 |
| Interrupters of VAscular daMAge in Malignant Hypertension analyse of angiogenic, vasoactive and VEGF systems - Malignant Hypertension | Completed | Centre Hospitalier de PAU | 45 | 2022-02-07 | 2024-10-30 | |
| Clinical Relevance of Nicardipine Induced Hypoxemia in the Intensive Care Unit Antihypertensive Agents - Hypoxemic Respiratory Failure, Side Effect | Unknown | University Hospital, Caen | 300 | 2021-11-15 | 2024-02-13 | |
| Clinical Study of Clevidipine Butyrate Injection in the Treatment of Hypertensive Emergency and Sub-emergency This is a randomized, single-blind, parallel-controlled clinical study with the original research clevidipine butyrate injection as the positive control drug, which is an equivalence test. - Hypertensive Emergency | Phase 3 | Unknown | Shenzhen People's Hospital | 10 | 2021-10-11 | 2021-09-14 |
| Prediction of Patient Deterioration Using Machine Learning Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2 - Infection, Heart Failure | Completed | Brigham and Women's Hospital | 526 | 2021-03-20 | 2026-03-17 | |
| Serum Potassium Prediction Using Machine Learning and Single-lead ECG Potassium estimation algorithm - Infection, Heart Failure | Withdrawn | Brigham and Women's Hospital | 2021-03-20 | 2026-03-25 | ||
| Prediction of Expected Length of Hospital Stay Using Machine Learning Infection, Heart Failure | Withdrawn | Brigham and Women's Hospital | 2021-03-20 | 2026-03-17 | ||
| Rural Home Hospital: Proof of Concept Home hospital care - Infection, Heart Failure | Not applicable | Completed | Brigham and Women's Hospital | 7 | 2021-02-18 | 2025-01-30 |
| Safety and Efficacy Study of Clevidipine Butyrate Injection in Hypertensive Emergencies Clevidipine Butyrate Injection, Ncardipine Hydrochloride Injection - Hypertensive Emergency | Phase 3 | Unknown | Nanjing Yoko Biomedical Co., Ltd. | 262 | 2020-07-27 | 2020-12-17 |
Showing 20 of 30. Sign in to see all of them.
Hypertension (10) · Asthma (9) · Heart Failure (9) · Infections (9) · Pulmonary Disease, Chronic Obstructive (9) · Renal Insufficiency, Chronic (9) · Emergencies (4) · Hypertension, Malignant (2) · Acute Kidney Injury (1) · Atypical Hemolytic Uremic Syndrome (1) · Diabetes Mellitus (1) · Essential Hypertension (1) · Hypoventilation (1) · Ischemic Stroke (1)
Cardiovascular Diseases (30) · Vascular Diseases (30) · Hypertension (20) · Disease Attributes (14) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Female Urogenital Diseases and Pregnancy Complications (11) · Respiratory Tract Diseases (11) · Urogenital Diseases (11) · Chronic Disease (10) · Female Urogenital Diseases (10) · Kidney Diseases (10) · Male Urogenital Diseases (10) · Renal Insufficiency (10) · Urologic Diseases (10)
Home Care Services, Hospital-Based (2) · Labetalol (2) · clevidipine (2) · Antihypertensive Agents (1) · Biological Specimen Banks (1) · Captopril (1) · Checklist (1) · Educational Status (1) · Nicardipine (1) · Nifedipine (1) · Single-Blind Method (1) · eculizumab (1)
Brigham and Women's Hospital (9) · Centre Hospitalier de PAU (2) · Ankara City Hospital Bilkent (1) · Assistance Publique - Hôpitaux de Paris (1) · CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. (1) · Columbia University (1) · Haseki Training and Research Hospital (1) · Johns Hopkins University (1) · Kardigan, Inc. (1) · Khon Kaen University (1) · Leiden University Medical Center (1) · Nanjing Yoko Biomedical Co., Ltd. (1) · Qilu Pharmaceutical (Hainan) Co., Ltd. (1) · RWTH Aachen University (1) · Russian Cardiology Research and Production Center (1)
United States (13) · France (4) · Turkey (Türkiye) (3) · China (2) · Canada (1) · Germany (1) · Pakistan (1) · Russia (1) · Thailand (1)
David Levine, MD MPH MA (4) · Adem Az, Assoc. Prof. (1) · Candace McNaughton, MD (1) · Changsheng Ma (1) · Evgeniy I Chazov, MD (1) · Jeffrey Schnipper, MD, MPH (1) · Joseph Varon, MD (1) · Junaid A Razzak (1) · Tessa Mulder, MD (1) · W. Frank Peacock, MD (1) · Whitney A. Booker, MD (1)
PMID 12441212, PMID 21707983, PMID 23055089, PMID 23381792, PMID 23535700, PMID 25141250, PMID 27294333, PMID 31415308, PMID 31842232, PMID 32371787, PMID 33479931, PMID 33954888, PMID 34690012, PMID 34825613, PMID 35195015, PMID 35323883, PMID 36040741, PMID 36352567, PMID 36418425, PMID 37644380, PMID 38132649, PMID 39604146, PMID 40672455, PMID 41231022, PMID 41324962, PMID 42555132
K23HL125670 (1), R21TW011175 (1)