12 recruiting, 10 completed, 8 not yet recruiting, 2 active not recruiting. 24 Not applicable, 4 Phase 4, 1 Phase 2, 1 Phase 3.
Follow ACL Reconstruction: new trials by email Literature Review of ACL Reconstruction trials Research Report on ACL Reconstruction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Anodal Transcranial Direct Current Stimulation on Muscle Inhibition After ACL Reconstruction Anodal Transcranial Direct Current Stimulation (tDCS), Standard Physical Therapy - ACL Reconstruction | Not applicable | Not yet recruiting | University of Lahore | 64 | 2026-11-01 | 2026-10-09 |
| The Effect of Plyometric Training in Post-ACLR Surgery Standard program, Plyometrics Training - Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Reconstruction Rehabilitation | Not applicable | Recruiting | Cairo University | 40 | 2026-10-01 | 2026-10-15 |
| The Effect of Isokinetic Vs Plyometric Training in Post-ACLR Surgery Isokinetic Training, Plyometrics Training - Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Reconstruction Rehabilitation | Not applicable | Recruiting | Cairo University | 40 | 2026-10-01 | 2026-10-15 |
| Mid-term Postoperative Clinical Evaluation of Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction Using the Over-The-Top Technique, Fixed With Metal Staples or Soft Anchors. ACL reconstruction using the Over-The-Top technique - ACL Reconstruction, Fixation | Not applicable | Not yet recruiting | Stefano Zaffagnini | 46 | 2026-09-01 | 2026-09-15 |
| Methylprednisolone Addition to Multimodal Pain Regimens After Anterior Cruciate Ligament Reconstruction Methyl Prednisolone (MP), Standard Post-Operative Pain Control, Surgeon's Standard ACL Postoperative Regimen - ACL Reconstruction | Phase 4 | Not yet recruiting | University of Alabama at Birmingham | 64 | 2026-09-01 | 2026-05-26 |
| Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction Losartan, Placebo - ACL Injury, ACL Reconstruction | Phase 4 | Not yet recruiting | Rush University Medical Center | 144 | 2026-08-01 | 2025-12-15 |
| Effects of Blood Flow Restriction Training and Instrument-Assisted Soft Tissue Mobilization for Pain, Strength, Range of Motion, and Kinesiophobia Among ACL Reconstruction Patients. Blood Flow Restriction Training, Instrument-Assisted Soft Tissue Mobilization (IASTM) - ACL Reconstruction | Not applicable | Active not recruiting | Lahore University of Biological and Applied Sciences | 46 | 2026-06-26 | 2026-10-14 |
| Readiness Outcomes Affecting Return to Sport 3.0 Mental Skills Training (MST) - ACL Reconstruction | Not applicable | Not yet recruiting | Boston Children's Hospital | 130 | 2026-06-01 | 2026-03-17 |
| Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET) ACL Reconstruction, Tenodesis | Recruiting | Stefano Zaffagnini | 51 | 2026-03-24 | 2026-04-22 | |
| Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection. PRP injection - ACL Reconstruction, Intraarticular Injection | Phase 2 | Recruiting | Lahore General Hospital | 60 | 2026-02-20 | 2026-03-13 |
| Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients Zynex NexWave Electrotherapy Device - ACL Reconstruction, ACL Surgery | Not applicable | Enrolling by invitation | University of Kansas Medical Center | 25 | 2026-02-10 | 2026-03-17 |
| Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training High Load Isokinetic Training with Blood Flow Restriction, Low Load Isokinetic Training with Blood Flow Restriction - ACL Reconstruction, ACL Repair | Not applicable | Not yet recruiting | Gulf Medical University | 60 | 2026-02-01 | 2026-02-05 |
| Study the Anti-inflammatory Effect of Tranexamic Acid When Used in Anterior Cruciate Ligament Reconstruction. Tranexamic Acid (TXA), Placebo (NaCl 0,9%) - ACL Reconstruction, Hemarthrosis | Phase 4 | Not yet recruiting | Chirec | 60 | 2026-01-20 | 2026-01-12 |
| Kinesiophobia vs. Task-Specific Fear: Defining Movement-Related Fear in ACL Reconstruction Patients Exposure to neutral images visualization, Exposure to nocive images visualisation, Exposure to anticipated realisation of a feared movement - ACL Reconstruction | Not applicable | Recruiting | Egas Moniz - Cooperativa de Ensino Superior, CRL | 21 | 2026-01-01 | 2026-09-10 |
| Application of Multiple Vertical Jump Tests in Return-to-Play Assessment for Anterior Cruciate Ligament Reconstruction Athletes ACL Reconstruction | Not yet recruiting | Kaohsiung Medical University | 36 | 2025-12-29 | 2025-12-22 | |
| Comparative Effectiveness of Blood Flow Restriction With or Without Total Motion Release in ACL Rehabilitation Blood Flow Restriction, Total Motion Release - ACL Injury, ACL Reconstruction | Not applicable | Completed | Green International University | 44 | 2025-11-02 | 2026-05-15 |
| Psychological and Physiological Parameters for Return-to-sport After ACL Reconstruction ACL Reconstruction | Completed | Johannes Kepler University of Linz | 30 | 2025-04-16 | 2026-04-20 | |
| Effect of Internal Brace on Outcomes Following ACL Reconstruction With BTB Autograft Arthrex Internal Brace, ACL Reconstruction - ACL Reconstruction | Not applicable | Recruiting | NYU Langone Health | 90 | 2025-03-17 | 2026-03-05 |
| Developing and Validating the Risk-taking Intention and Sport Engagement After ACL Reconstruction (RISE-ACL) Scale RISE-ACL development, RISE-ACL scale validation - ACL Surgery, ACL Injuries | Not applicable | Active not recruiting | University Hospital, Caen | 162 | 2025-02-03 | 2025-08-05 |
| Test of Return to Sport After ACL Reconstruction and Cognitive Task. Single leg hop for distance, Single leg hop for distance plus cognitive task - ACL Reconstruction, Cognitive Function | Not applicable | Completed | Simon VALOT | 31 | 2025-01-08 | 2025-04-09 |
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Anterior Cruciate Ligament Injuries (11) · Osteoarthritis (3) · Muscular Atrophy (2) · Asthenia (1) · Athletic Injuries (1) · Hemarthrosis (1) · Kinesiophobia (1) · Knee Injuries (1) · Motor Activity (1) · Osteoarthritis, Knee (1) · Pain (1) · Pain, Postoperative (1) · Risk-Taking (1) · Wounds and Injuries (1)
Leg Injuries (12) · Wounds and Injuries (12) · Knee Injuries (11) · Pathological Conditions, Signs and Symptoms (5) · Joint Diseases (4) · Musculoskeletal Diseases (4) · Neurologic Manifestations (4) · Signs and Symptoms (4) · Arthritis (3) · Rheumatic Diseases (3) · Atrophy (2) · Behavior (2) · Nervous System Diseases (2) · Neuromuscular Manifestations (2) · Pathologic Processes (2)
Blood Flow Restriction Therapy (4) · Adrenal Cortex Hormones (1) · Alendronate (1) · Estrogens, Conjugated (USP) (1) · Losartan (1) · Physical Examination (1) · Physical Therapy Modalities (1) · Proteins (1) · Rehabilitation (1) · Sodium Chloride (1) · Testosterone (1) · Tranexamic Acid (1) · Transcranial Direct Current Stimulation (1) · testosterone enanthate (1)
Cairo University (2) · Stefano Zaffagnini (2) · University Hospital, Caen (2) · Berivan Beril Kılıç (1) · Boston Children's Hospital (1) · Chang Gung Memorial Hospital (1) · Charite University, Berlin, Germany (1) · Chinese University of Hong Kong (1) · Chirec (1) · Duke University (1) · Egas Moniz - Cooperativa de Ensino Superior, CRL (1) · Green International University (1) · Gulf Medical University (1) · Illinois Center for Orthopaedic Research and Education (1) · Johannes Kepler University of Linz (1)
United States (12) · France (3) · Pakistan (3) · Canada (2) · Egypt (2) · Italy (2) · Austria (1) · Belgium (1) · Germany (1) · Hong Kong (1) · Portugal (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Aaron J Krych, MD (1) · Adam Rivadeneyra, MD (1) · Ahmed El Melhat (1) · Ahmed El Melhat, PhD (1) · Amit Momaya, MD (1) · Andrew Bi, MD (1) · Dean C Taylor, MD (1) · Dr Shaoib Waqas, Phd (1) · Jorge Chahla, MD, PhD (1) · Karim Touihri (1) · Matthew D Milewski, MD (1) · Michael J. Alaia, MD (1) · Nicholas G. Mohtadi, MD, MSc (1)
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R01AR055563 (1)