5 terminated. 5 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Terminated 5 |
| Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Acidosis: new trials by email Literature Review of Acidosis trials Research Report on Acidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM) zagociguat 15mg - Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome) | Phase 2 | Terminated | Tisento Therapeutics | 37 | 2025-08-18 | 2026-11-03 |
| Bone in CKD Alkali Response (BICARb Pilot Trial) Potassium Citrate Extended Release Oral Tablet, Placebo, Potassium Citrate and Citric Acid Oral Solution - Chronic Kidney Diseases, Bone Loss | Phase 2 / Phase 3 | Terminated | Albert Einstein College of Medicine | 6 | 2024-08-15 | 2026-07-28 |
| Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Thiamine, placebo - Cardiac Arrest, Shock | Phase 2 | Terminated | Beth Israel Deaconess Medical Center | 41 | 2017-05-01 | 2025-04-10 |
| A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease Cysteamine Bitartrate - Mitochondrial Diseases | Phase 2 | Terminated | Amgen | 22 | 2015-05-19 | 2024-12-27 |
| Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation nitric oxide for inhalation, Oxygen - Lung Disease, Hypoxemia | Phase 1 / Phase 2 | Terminated | Mallinckrodt | 7 | 2002-05-01 | 2016-10-19 |
Acidosis, Lactic (3) · Acidosis, Respiratory (1) · Beriberi (1) · Bone Diseases, Metabolic (1) · Epilepsies, Myoclonic (1) · Fractures, Bone (1) · Heart Arrest (1) · Hypoxia (1) · Leigh Disease (1) · Lung Diseases (1) · MELAS Syndrome (1) · Mitochondrial Diseases (1) · Mitochondrial Encephalomyopathies (1) · Mitochondrial encephalopathy (1)
Acid-Base Imbalance (5) · Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5) · Pathological Conditions, Signs and Symptoms (4) · Musculoskeletal Diseases (3) · Pathologic Processes (3) · Brain Diseases (2) · Brain Diseases, Metabolic (2) · Brain Diseases, Metabolic, Inborn (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Chronic Disease (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Disease Attributes (2)
Citric Acid (1) · Cysteamine (1) · Endothelium-Dependent Relaxing Factors (1) · Inhalation (1) · Nitric Oxide (1) · Oxygen (1) · Potassium Citrate (1) · Saline Solution (1) · Thiamine (1)
Albert Einstein College of Medicine (1) · Amgen (1) · Beth Israel Deaconess Medical Center (1) · Mallinckrodt (1) · Tisento Therapeutics (1)
United States (5) · Australia (1) · Germany (1) · Italy (1) · United Kingdom (1)
Katherine M Berg, MD (1) · Kimberly Reidy, MD (1) · Waldemar Carlo, MD (1)
2023 (1), K23HL128814 (1), R01DK131811 (1)