13 completed, 8 recruiting, 3 unknown, 2 not yet recruiting. 7 Not applicable, 3 Phase 2, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 2, Recruiting 2, Unknown 2, Enrolling by invitation 1 |
| Phase 2 | 3 | Completed 2, Active not recruiting 1 |
| Phase 4 | 2 | Completed 1, Recruiting 1 |
Follow Williams Syndrome: new trials by email Literature Review of Williams Syndrome trials Research Report on Williams Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Case-Control Observational Study of Peripheral Blood-Derived iPSC Models to Investigate Oligodendrocyte Lineage Development in Children With Williams Syndrome and Healthy Controls one-time peripheral blood collection - Williams Syndrome, Induced Pluripotent Stem Cell (Ips Cell) | Not yet recruiting | Qilu Hospital of Shandong University | 6 | 2026-04-01 | 2026-04-17 | |
| Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder Williams Syndrome, Autism Disorder | Not yet recruiting | Qilu Hospital of Shandong University | 75 | 2026-04-01 | 2026-04-03 | |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| Physical Activity and Community EmPOWERment Project PACE Program - Intellectual Disability, Neurodevelopmental Disorders | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 376 | 2025-01-10 | 2026-02-23 |
| Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants Williams Beuren Syndrome, Williams Syndrome | Recruiting | University of Pennsylvania | 2000 | 2024-10-21 | 2026-06-08 | |
| Phonological Constraints on Language Development in Individuals With Williams Syndrome EEG-NIRS protocol, Questionnaire - Williams Syndrome, Language | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 130 | 2024-07-05 | 2025-12-16 |
| Clemastine Treatment in Individuals With Williams Syndrome Open Label Clemastine with a blinded randomize withdrawal - Williams Syndrome | Phase 2 | Active not recruiting | Sheba Medical Center | 30 | 2024-04-01 | 2026-03-06 |
| Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome Clemastine Fumarate Tablets, corn starch tablets - Williams Syndrome, Child | Phase 2 | Completed | Qilu Hospital of Shandong University | 28 | 2024-03-20 | 2026-03-19 |
| Motor Deficits and Signal Conduction in Individuals With Williams Syndrome Williams Syndrome | Withdrawn | Sheba Medical Center | 2023-02-01 | 2024-06-25 | ||
| Buspirone Treatment of Anxiety in Williams Syndrome Buspirone - Williams Syndrome, Anxiety | Phase 4 | Completed | Massachusetts General Hospital | 20 | 2021-08-01 | 2024-12-03 |
| Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication Syndrome Physical examination and Urine and blood samples, Urine and blood samples - Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome | Not applicable | Unknown | Hospices Civils de Lyon | 90 | 2019-10-01 | 2019-08-12 |
| Cognitive and Behavioral Therapy of Anxiety in Williams Syndrome Cognitive and Behavioral Therapy - Williams Syndrome, Anxiety | Unknown | University Hospital, Montpellier | 5 | 2019-08-29 | 2019-10-18 | |
| Parent and Infant Inter(X)Action Intervention (PIXI) Parent-Infant Inter(X)action Intervention (PIXI) - Fragile X Syndrome, Angelman Syndrome | Not applicable | Enrolling by invitation | RTI International | 120 | 2018-11-30 | 2026-07-13 |
| GROWing Up With Rare GENEtic Syndromes Retrospective file studies - Prader-Willi Syndrome, PWS-like Syndrome | Recruiting | dr. Laura C. G. de Graaff-Herder | 600 | 2018-10-01 | 2023-09-06 | |
| Williams Syndrome Strength, Hormones, Activity & Adiposity, DNA Programming, Eating Study Williams Syndrome, Lipedema | Completed | Massachusetts General Hospital | 144 | 2018-10-01 | 2023-10-19 | |
| Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren Syndrome Manipulation of valence and modality, Spatial and recognition memory, Source and content memory - Mental Disorders | Not applicable | Completed | Hôpital le Vinatier | 280 | 2018-06-28 | 2021-02-09 |
| Cooperative Parent Mediated Therapy in Children With Fragile X Syndrome and Williams Syndrome Cooperative Parent Mediated Therapy" (CPMT), As usual - Fragile X Syndrome, Williams Syndrome | Not applicable | Unknown | Bambino Gesù Hospital and Research Institute | 14 | 2017-05-17 | 2020-10-30 |
| WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study) Williams Syndrome, Cardiovascular Disease | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 43 | 2017-03-03 | 2026-10-13 | |
| Impact of Elastin Mediated Vascular Stiffness on End Organs Williams Syndrome, Supravalvular Aortic Stenosis | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 159 | 2016-12-02 | 2026-10-08 | |
| Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank Williams Syndrome, Supravalvular Aortic Stenosis | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 305 | 2016-05-11 | 2026-08-28 |
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DiGeorge Syndrome (5) · Fragile X Syndrome (5) · Autism Spectrum Disorder (4) · Prader-Willi Syndrome (4) · Aortic Stenosis, Supravalvular (3) · Cardiovascular Diseases (3) · De Lange Syndrome (3) · Down Syndrome (3) · Rare Diseases (3) · Angelman Syndrome (2) · Anxiety Disorders (2) · Autistic Disorder (2) · Chromosome Aberrations (2) · Developmental Disabilities (2)
Aortic Valve Disease (29) · Aortic Valve Stenosis (29) · Chromosome Disorders (29) · Congenital Abnormalities (29) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (29) · Heart Diseases (29) · Heart Valve Diseases (29) · Nervous System Diseases (29) · Neurobehavioral Manifestations (29) · Genetic Diseases, Inborn (27) · Intellectual Disability (27) · Neurologic Manifestations (27) · Aortic Stenosis, Supravalvular (26) · Cardiovascular Diseases (26) · Mental Disorders (9)
Blood Specimen Collection (1) · Buspirone (1) · Clemastine (1) · Cognitive Behavioral Therapy (1) · Exome Sequencing (1) · Fluoxetine (1) · Methylphenidate (1) · Minoxidil (1) · Restraint, Physical (1) · Risperidone (1) · Starch (1) · Surveys and Questionnaires (1) · Urination (1) · Vitamin D (1)
Hospices Civils de Lyon (3) · Massachusetts General Hospital (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Qilu Hospital of Shandong University (3) · Sheba Medical Center (2) · Bambino Gesù Hospital and Research Institute (1) · Centre Hospitalier Universitaire, Amiens (1) · Healing Hope International (1) · Hôpital le Vinatier (1) · National Center for Research Resources (NCRR) (1) · National Institute of Mental Health (NIMH) (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · RTI International (1) · Sanford Health (1) · The Chaim Sheba Medical Center (1)
United States (15) · France (5) · Israel (3) · China (2) · Australia (1) · Italy (1) · Netherlands (1)
Manfred Boehm, M.D. (3) · Anne Wheeler, PhD (1) · Benjamin Yerys, PhD (1) · Bonita P Klein-Tasman, Ph.D. (1) · Brianne R Tomaszewski, PhD., MPH (1) · Carolyn Mervis, PhD (1) · Daniel Rader, MD (1) · Dr. Tina Casoglos-Adamopoulos, OT, OTD, BCP (1) · Edward Brodkin, MD (1) · James R. Lupski (1) · Karen F Berman, M.D. (1) · Massimiliano Rossi, MD (1)
PMID 29614955, PMID 31138170, PMID 33667672, PMID 36752464, PMID 37010888, PMID 37633900
R01AG076678 (1)