18 completed, 8 recruiting, 3 not yet recruiting, 3 unknown. 10 Not applicable, 3 Phase 2, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 4, Recruiting 2, Unknown 2, Enrolling by invitation 1, Not yet recruiting 1 |
| Phase 2 | 3 | Completed 2, Active not recruiting 1 |
| Phase 4 | 2 | Completed 1, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial to Evaluate the Effects of the NeuEve Dryness Treatment Kit on Vaginal Health, Comfort, and Quality of Life in Postmenopausal Women Intervention - Relieves Vaginal Dryness / Improves Self-Lubrication, Improves Strength & Elasticity of Vagina (Aka Collagen and Elastin) | Not applicable | Not yet recruiting | NeuEve | 40 | 2026-09-01 | 2026-10-26 |
| A Case-Control Observational Study of Peripheral Blood-Derived iPSC Models to Investigate Oligodendrocyte Lineage Development in Children With Williams Syndrome and Healthy Controls one-time peripheral blood collection - Williams Syndrome, Induced Pluripotent Stem Cell (Ips Cell) | Not yet recruiting | Qilu Hospital of Shandong University | 6 | 2026-04-01 | 2026-04-17 | |
| Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder Williams Syndrome, Autism Disorder | Not yet recruiting | Qilu Hospital of Shandong University | 75 | 2026-04-01 | 2026-04-03 | |
| Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD) | Recruiting | Healing Hope International | 100 | 2026-03-01 | 2026-03-25 | |
| Physical Activity and Community EmPOWERment Project PACE Program - Intellectual Disability, Neurodevelopmental Disorders | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 376 | 2025-01-10 | 2026-02-23 |
| Characterization and Natural History of Williams Syndrome and Other Chromosome 7q11.23 Variants Williams Beuren Syndrome, Williams Syndrome | Recruiting | University of Pennsylvania | 2000 | 2024-10-21 | 2026-06-08 | |
| Phonological Constraints on Language Development in Individuals With Williams Syndrome EEG-NIRS protocol, Questionnaire - Williams Syndrome, Language | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 130 | 2024-07-05 | 2025-12-16 |
| Clemastine Treatment in Individuals With Williams Syndrome Open Label Clemastine with a blinded randomize withdrawal - Williams Syndrome | Phase 2 | Active not recruiting | Sheba Medical Center | 30 | 2024-04-01 | 2026-03-06 |
| Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome Clemastine Fumarate Tablets, corn starch tablets - Williams Syndrome, Child | Phase 2 | Completed | Qilu Hospital of Shandong University | 28 | 2024-03-20 | 2026-03-19 |
| Motor Deficits and Signal Conduction in Individuals With Williams Syndrome Williams Syndrome | Withdrawn | Sheba Medical Center | 2023-02-01 | 2024-06-25 | ||
| Buspirone Treatment of Anxiety in Williams Syndrome Buspirone - Williams Syndrome, Anxiety | Phase 4 | Completed | Massachusetts General Hospital | 20 | 2021-08-01 | 2024-12-03 |
| Gene First Approach to Connective Tissue Disease Abnormal Elastogenesis, Vascular Diseases | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 32 | 2021-04-22 | 2026-08-07 | |
| Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication Syndrome Physical examination and Urine and blood samples, Urine and blood samples - Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome | Not applicable | Unknown | Hospices Civils de Lyon | 90 | 2019-10-01 | 2019-08-12 |
| Cognitive and Behavioral Therapy of Anxiety in Williams Syndrome Cognitive and Behavioral Therapy - Williams Syndrome, Anxiety | Unknown | University Hospital, Montpellier | 5 | 2019-08-29 | 2019-10-18 | |
| Comparison of Spectral Photon Counting CT (SPCCT) With Dual Energy CT (DECT) and Magnetic Resonance Imaging (MRI) for Plaque and Lumen Carotid Arteries Evaluation Spectral Photon Counting Computed Tomography (SPCCT), Dual Energy CT (DECT) - Supra-Aortic Stenosis | Not applicable | Completed | Hospices Civils de Lyon | 22 | 2019-06-20 | 2024-07-15 |
| Parent and Infant Inter(X)Action Intervention (PIXI) Parent-Infant Inter(X)action Intervention (PIXI) - Fragile X Syndrome, Angelman Syndrome | Not applicable | Enrolling by invitation | RTI International | 120 | 2018-11-30 | 2026-07-13 |
| Early Check: Expanded Screening in Newborns Confirmatory Testing - Spinal Muscular Atrophy, Fragile X Syndrome | Active not recruiting | RTI International | 30000 | 2018-10-15 | 2026-07-01 | |
| GROWing Up With Rare GENEtic Syndromes Retrospective file studies - Prader-Willi Syndrome, PWS-like Syndrome | Recruiting | dr. Laura C. G. de Graaff-Herder | 600 | 2018-10-01 | 2023-09-06 | |
| Williams Syndrome Strength, Hormones, Activity & Adiposity, DNA Programming, Eating Study Williams Syndrome, Lipedema | Completed | Massachusetts General Hospital | 144 | 2018-10-01 | 2023-10-19 | |
| Broad Band Light for the Treatment and Prevention of Senile Purpura Broad Band Light (BBL) - Senile Purpura, Bateman's Purpura | Not applicable | Completed | Siperstein Dermatology | 10 | 2018-08-27 | 2021-04-13 |
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Williams Syndrome (29) · Fragile X Syndrome (6) · DiGeorge Syndrome (5) · Prader-Willi Syndrome (5) · Autism Spectrum Disorder (4) · Angelman Syndrome (3) · Cardiovascular Diseases (3) · De Lange Syndrome (3) · Down Syndrome (3) · Rare Diseases (3) · Rett Syndrome (3) · Anxiety Disorders (2) · Ataxia with vitamin E deficiency (2) · Autistic Disorder (2)
Aortic Valve Disease (36) · Aortic Valve Stenosis (36) · Heart Diseases (36) · Heart Valve Diseases (36) · Cardiovascular Diseases (33) · Chromosome Disorders (30) · Congenital Abnormalities (30) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (30) · Nervous System Diseases (30) · Neurobehavioral Manifestations (30) · Genetic Diseases, Inborn (28) · Intellectual Disability (28) · Neurologic Manifestations (28) · Pathological Conditions, Signs and Symptoms (13)
Blood Specimen Collection (1) · Buspirone (1) · Clemastine (1) · Cognitive Behavioral Therapy (1) · Exome Sequencing (1) · Fluoxetine (1) · Methods (1) · Methylphenidate (1) · Minoxidil (1) · Restraint, Physical (1) · Risperidone (1) · Starch (1) · Surveys and Questionnaires (1) · Urination (1) · Vitamin D (1)
Hospices Civils de Lyon (4) · National Heart, Lung, and Blood Institute (NHLBI) (4) · Massachusetts General Hospital (3) · Qilu Hospital of Shandong University (3) · RTI International (2) · Sheba Medical Center (2) · Bambino Gesù Hospital and Research Institute (1) · Centre Hospitalier Universitaire, Amiens (1) · Healing Hope International (1) · Hôpital le Vinatier (1) · National Center for Research Resources (NCRR) (1) · National Institute of Mental Health (NIMH) (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · NeuEve (1) · Sanford Health (1)
United States (20) · France (6) · Israel (3) · China (2) · Finland (1) · Italy (1) · Netherlands (1)
Manfred Boehm, M.D. (4) · Anne Wheeler, PhD (1) · Benjamin Yerys, PhD (1) · Bonita P Klein-Tasman, Ph.D. (1) · Brianne R Tomaszewski, PhD., MPH (1) · Carolyn Mervis, PhD (1) · Curt Scharfe, MD, PhD (1) · Daniel Rader, MD (1) · Dr. Tina Casoglos-Adamopoulos, OT, OTD, BCP (1) · Edward Brodkin, MD (1) · James R. Lupski (1) · Karen F Berman, M.D. (1) · Massimiliano Rossi, MD (1)
PMID 29614955, PMID 31138170, PMID 31315600, PMID 33667672, PMID 35142618, PMID 36752464, PMID 37010888, PMID 37633900
R01AG076678 (1)