20 completed, 7 unknown, 2 not yet recruiting, 1 enrolling by invitation. 19 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 11, Unknown 4, Not yet recruiting 2, Enrolling by invitation 1, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Vegetative State: new trials by email Literature Review of Vegetative State trials Research Report on Vegetative State
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy - Disorders of Consciousness, Vegetative State | Not applicable | Not yet recruiting | Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. | 200 | 2026-12-01 | 2026-10-02 |
| Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Liege | 4 | 2026-09-01 | 2026-10-19 |
| Effectiveness of tTIs for Improving Consciousness in Patients With DoC Theta-burst Patterned Temporal Interference Stimulation (tTIs), Sham Temporal Interference Stimulation - Disorders of Consciousness, Vegetative State | Not applicable | Recruiting | Zhujiang Hospital | 136 | 2026-03-08 | 2026-04-20 |
| Prognostication of Recovery in Early Disorders of Consciousness Study Functional MRI (fMRI) - Disorder of Consciousness, Comatose | Not applicable | Enrolling by invitation | University of Pennsylvania | 150 | 2023-03-08 | 2026-07-30 |
| Eye Tracking Technology in the Diagnosis of Neurological Patients Postcomatose Unawareness State, Minimally Conscious State | Completed | AssisTech Sp. z o.o. | 90 | 2022-05-01 | 2023-07-20 | |
| Cerebellar iTBS in Patients With Disorders of Consciousness iTBS stimulation, sham stimulation - Disorder of Consciousness, Vegetative State | Not applicable | Unknown | Xijing Hospital | 44 | 2022-04-29 | 2022-09-28 |
| Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness Active taVNS, sham taVNS - Consciousness Disorder, Minimally Conscious State | Not applicable | Completed | University of Liege | 44 | 2022-02-09 | 2026-05-01 |
| Chinese Validation of the Simplified Evaluation of CONsciousness Disorders（SECONDs） Simplified Evaluation of CONsciousness Disorders (SECONDs) - Brain Diseases, Vegetative State | Not applicable | Completed | Hangzhou Normal University | 49 | 2021-12-20 | 2022-08-11 |
| Neural, Behavioural, and Clinical Effects of tDCS in PDOC; Feasibility Study Transcranial direct current stimulation - Consciousness Disorder, Brain Injuries | Not applicable | Unknown | University of Birmingham | 15 | 2021-07-01 | 2021-05-03 |
| The Use of LIFUP in Chronic Disorders of Consciousness BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation - Disorder of Consciousness, Vegetative State | Not applicable | Completed | Casa Colina Hospital and Centers for Healthcare | 16 | 2021-06-21 | 2023-05-06 |
| Validation of the Chinese Version of the SECONDs Simplified Evaluation of CONsciousness Disorders (SECONDs) - Minimally Conscious State, Vegetative State | Not applicable | Completed | Hangzhou Normal University | 120 | 2020-11-10 | 2022-07-08 |
| Development of a Point of Care System for Automated Coma Prognosis Coma, Disorder of Consciousness | Unknown | McMaster University | 33 | 2019-10-01 | 2023-02-06 | |
| Spinal Cord Stimulation in Patients With Disorders of Consciousness spinal cord stimulation - Disorder of Consciousness, Minimally Conscious State | Not applicable | Unknown | Huashan Hospital | 40 | 2019-07-01 | 2019-07-08 |
| tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury Anodal tDCS, Usual care - Consciousness Disorders, Brain Injuries | Terminated | Montecatone Rehabilitation Institute S.p.A. | 1 | 2018-06-18 | 2020-08-14 | |
| The Effects of Olfactory Stimulation on Diagnosis and Prognosis of DOC Patients Coma Recovery Scale-Revised - Minimally Conscious State, Vegetative State | Completed | Jing Wang | 20 | 2018-03-15 | 2020-12-29 | |
| Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness. Analgesic administration, Placebo administration - Disorders of Consciousness, Severe Brain Injury | Phase 1 | Completed | University of Liege | 19 | 2018-02-21 | 2021-05-03 |
| Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes anodal tDCS, sham tDCS - Vegetative State, Minimally Conscious State | Not applicable | Completed | University of Liege | 15 | 2018-01-01 | 2019-07-17 |
| Reliability and Validity of the NCS (NCS-R)-Chinese Version Nociception Coma Scale (NCS) - Minimally Conscious State, Vegetative State | Not applicable | Completed | Hangzhou Normal University | 62 | 2017-10-28 | 2018-04-11 |
| Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients transcranial direct current stimulation (tDCS) / Comparison of current intensities - Disorder of Consciousness, Minimally Conscious State | Phase 3 | Unknown | Groupe Hospitalier Pitie-Salpetriere | 300 | 2017-01-01 | 2017-01-18 |
| The Initiation of Swallowing Can Indicate the Prognosis of DOC Coma Recovery Scale-Revised - Minimally Conscious State, Vegetative State | Completed | Hangzhou Normal University | 24 | 2016-06-03 | 2018-04-25 |
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Persistent Vegetative State (32) · Consciousness Disorders (27) · Coma (7) · Brain Injuries (6) · Brain Injuries, Traumatic (6) · Cognitive Dysfunction (3) · Disease (2) · Hypoxia, Brain (2) · Stroke (2) · Akinetic Mutism (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Coma, Post-Head Injury (1) · Hypoxia (1) · Muscle Hypertonia (1)
Brain Damage, Chronic (32) · Neurobehavioral Manifestations (32) · Neurologic Manifestations (32) · Pathological Conditions, Signs and Symptoms (32) · Signs and Symptoms (32) · Brain Diseases (31) · Central Nervous System Diseases (31) · Nervous System Diseases (31) · Unconsciousness (31) · Mental Disorders (27) · Neurocognitive Disorders (27) · Craniocerebral Trauma (9) · Trauma, Nervous System (8) · Wounds and Injuries (8) · Consciousness Disorders (5)
Transcranial Direct Current Stimulation (9) · Magnetic Resonance Imaging (2) · Spinal Cord Stimulation (1) · Transcranial Magnetic Stimulation (1)
Hangzhou Normal University (6) · University of Liege (6) · AssisTech Sp. z o.o. (1) · Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. (1) · Casa Colina Hospital and Centers for Healthcare (1) · Centre Hospitalier Universitaire de Liege (1) · Clinical Institute of the Brain, Russia (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Groupe Hospitalier Pitie-Salpetriere (1) · Hospices Civils de Lyon (1) · Huashan Hospital (1) · IRCCS San Camillo, Venezia, Italy (1) · Jing Wang (1) · McMaster University (1) · Montecatone Rehabilitation Institute S.p.A. (1)
China (10) · Belgium (6) · Italy (3) · United States (3) · France (2) · Canada (1) · Israel (1) · Poland (1) · Russia (1) · United Kingdom (1)
Haibo Di, Pro (3) · Alison Fox-Robichaud, MD (1) · Andrey A Belkin, Prof., MD, Phd (1) · Angela Morreale, MD (1) · Anqi Wang (1) · Aurore Thibaut (1) · Aurore Thibaut, PhD (1) · Bartosz Kunka, Ph.D. (1) · Caroline Schnakers, PhD (1) · David J Fischer, MD (1) · Efraim Jaul, MD (1) · Fanny Montulet (1) · Francesco Piccione, MD (1) · Haibo Di (1)
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K23NS136745 (1)