11 completed, 4 unknown, 2 not yet recruiting, 1 enrolling by invitation. 19 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 11, Unknown 4, Not yet recruiting 2, Enrolling by invitation 1, Recruiting 1 |
Follow Vegetative State: new trials by email Literature Review of Vegetative State trials Research Report on Vegetative State
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy - Disorders of Consciousness, Vegetative State | Not applicable | Not yet recruiting | Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. | 200 | 2026-12-01 | 2026-10-02 |
| Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Liege | 4 | 2026-09-01 | 2026-10-19 |
| Effectiveness of tTIs for Improving Consciousness in Patients With DoC Theta-burst Patterned Temporal Interference Stimulation (tTIs), Sham Temporal Interference Stimulation - Disorders of Consciousness, Vegetative State | Not applicable | Recruiting | Zhujiang Hospital | 136 | 2026-03-08 | 2026-04-20 |
| Prognostication of Recovery in Early Disorders of Consciousness Study Functional MRI (fMRI) - Disorder of Consciousness, Comatose | Not applicable | Enrolling by invitation | University of Pennsylvania | 150 | 2023-03-08 | 2026-07-30 |
| Cerebellar iTBS in Patients With Disorders of Consciousness iTBS stimulation, sham stimulation - Disorder of Consciousness, Vegetative State | Not applicable | Unknown | Xijing Hospital | 44 | 2022-04-29 | 2022-09-28 |
| Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness Active taVNS, sham taVNS - Consciousness Disorder, Minimally Conscious State | Not applicable | Completed | University of Liege | 44 | 2022-02-09 | 2026-05-01 |
| Chinese Validation of the Simplified Evaluation of CONsciousness Disorders（SECONDs） Simplified Evaluation of CONsciousness Disorders (SECONDs) - Brain Diseases, Vegetative State | Not applicable | Completed | Hangzhou Normal University | 49 | 2021-12-20 | 2022-08-11 |
| Neural, Behavioural, and Clinical Effects of tDCS in PDOC; Feasibility Study Transcranial direct current stimulation - Consciousness Disorder, Brain Injuries | Not applicable | Unknown | University of Birmingham | 15 | 2021-07-01 | 2021-05-03 |
| The Use of LIFUP in Chronic Disorders of Consciousness BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation - Disorder of Consciousness, Vegetative State | Not applicable | Completed | Casa Colina Hospital and Centers for Healthcare | 16 | 2021-06-21 | 2023-05-06 |
| Validation of the Chinese Version of the SECONDs Simplified Evaluation of CONsciousness Disorders (SECONDs) - Minimally Conscious State, Vegetative State | Not applicable | Completed | Hangzhou Normal University | 120 | 2020-11-10 | 2022-07-08 |
| Spinal Cord Stimulation in Patients With Disorders of Consciousness spinal cord stimulation - Disorder of Consciousness, Minimally Conscious State | Not applicable | Unknown | Huashan Hospital | 40 | 2019-07-01 | 2019-07-08 |
| Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes anodal tDCS, sham tDCS - Vegetative State, Minimally Conscious State | Not applicable | Completed | University of Liege | 15 | 2018-01-01 | 2019-07-17 |
| Reliability and Validity of the NCS (NCS-R)-Chinese Version Nociception Coma Scale (NCS) - Minimally Conscious State, Vegetative State | Not applicable | Completed | Hangzhou Normal University | 62 | 2017-10-28 | 2018-04-11 |
| Vagal Nerve Stimulation in Coma Patients stimulation device - Chronic Consciousness Disorders, Vegetative State | Not applicable | Unknown | Hospices Civils de Lyon | 4 | 2015-10-01 | 2019-11-25 |
| Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness Anodal tDCS, Sham tDCS - Vegetative State, Minimally Conscious State | Not applicable | Completed | University of Liege | 46 | 2015-01-01 | 2019-01-30 |
| Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients Transcranial direct current stimulation - Disorder of Consciousness, MMN | Not applicable | Completed | Oded Meiron | 16 | 2014-04-30 | 2024-02-28 |
| Transcranial Brain Stimulation in Vegetative State Patients Transcranial direct current stimulation (tDCS), Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (SHAM) - Vegetative State, Minimally Conscious State | Not applicable | Completed | IRCCS San Camillo, Venezia, Italy | 40 | 2011-07-01 | 2015-03-25 |
| Navigated Brain Stimulation in Diagnosis of Minimally Conscious State Navigated transcranial magnetic brain stimulation - Vegetative State, Stroke | Not applicable | Completed | Clinical Institute of the Brain, Russia | 6 | 2011-06-01 | 2013-02-15 |
| The Efficacy of Familiar Voice Stimulation During Coma Recovery Familiar Auditory Sensory Training, Sham Auditory Sensory Training - Traumatic Brain Injury, Coma | Not applicable | Completed | VA Office of Research and Development | 21 | 2008-07-01 | 2019-06-06 |
Persistent Vegetative State (19) · Consciousness Disorders (15) · Brain Injuries, Traumatic (5) · Coma (4) · Brain Injuries (3) · Hypoxia, Brain (2) · Stroke (2) · Akinetic Mutism (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Disease (1) · Unconsciousness (1)
Brain Damage, Chronic (19) · Nervous System Diseases (19) · Neurobehavioral Manifestations (19) · Neurologic Manifestations (19) · Pathological Conditions, Signs and Symptoms (19) · Signs and Symptoms (19) · Brain Diseases (18) · Central Nervous System Diseases (18) · Unconsciousness (18) · Mental Disorders (15) · Neurocognitive Disorders (15) · Craniocerebral Trauma (6) · Trauma, Nervous System (6) · Wounds and Injuries (6) · Consciousness Disorders (4)
Transcranial Direct Current Stimulation (5) · Magnetic Resonance Imaging (1) · Spinal Cord Stimulation (1) · Transcranial Magnetic Stimulation (1)
Hangzhou Normal University (3) · University of Liege (3) · Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. (1) · Casa Colina Hospital and Centers for Healthcare (1) · Centre Hospitalier Universitaire de Liege (1) · Clinical Institute of the Brain, Russia (1) · Hospices Civils de Lyon (1) · Huashan Hospital (1) · IRCCS San Camillo, Venezia, Italy (1) · Oded Meiron (1) · University of Birmingham (1) · University of Pennsylvania (1) · VA Office of Research and Development (1) · Xijing Hospital (1) · Zhujiang Hospital (1)
China (7) · Belgium (3) · United States (3) · France (1) · Israel (1) · Italy (1) · Russia (1) · United Kingdom (1)
Andrey A Belkin, Prof., MD, Phd (1) · Anqi Wang (1) · Aurore Thibaut (1) · Aurore Thibaut, PhD (1) · Caroline Schnakers, PhD (1) · David J Fischer, MD (1) · Efraim Jaul, MD (1) · Fanny Montulet (1) · Francesco Piccione, MD (1) · Haibo Di (1) · Haibo Di, Pro (1) · Haibo Di, Pro. (1) · Martin Monti, PhD (1) · Nicolas Lejeune (1)
PMID 10869046, PMID 20647501, PMID 21876461, PMID 22224835, PMID 23341285, PMID 24574549, PMID 25613986, PMID 27567470, PMID 28901969, PMID 31401074, PMID 36467262, PMID 42311279
K23NS136745 (1)