16 completed, 6 not yet recruiting, 5 recruiting, 3 unknown. 31 Not applicable, 2 Early Phase 1, 1 Phase 1.
Follow Vagus Nerve Stimulation: new trials by email Literature Review of Vagus Nerve Stimulation trials Research Report on Vagus Nerve Stimulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| How Does Vagus Nerve Stimulation Affect Blood Glucose, Food, and Movement Cravings? Active taVNS, Sham taVNS - Vagus Nerve Stimulation | Not applicable | Withdrawn | University of Minnesota | 2026-09-01 | 2026-07-20 | |
| TaVNS for Capsaicin-Induced Pain Transcutaneous Auricular Vagus Nerve Stimulation - Pain Management, Capsaicin-Induced Pain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 30 | 2026-07-10 | 2026-07-22 |
| Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression Transcutaneous vagal nerve stimulation, Sham (No Treatment) - Post Operative Delirium, Cognitive Impairment | Not applicable | Recruiting | Northwestern University | 40 | 2026-04-23 | 2026-05-28 |
| Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters Pulsetto FIT™ - Sham tcVNS, Pulsetto FIT™ - tcVNS 10 Hz, Pulsetto FIT™ - tcVNS 25 Hz - Vagus Nerve Stimulation, Autonomic Nervous System | Not applicable | Not yet recruiting | SEFA HAKTAN HATIK | 36 | 2025-12-22 | 2025-12-10 |
| Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences Active taVNS, Sham Stimulation - Cognitive Assessment, Cognition | Not applicable | Not yet recruiting | Bahçeşehir University | 60 | 2025-12-01 | 2025-12-01 |
| Vagal Nerve Stimulation To Enhance Cognition and Learning VNS for Cognition - Vagus Nerve Stimulation, Stroke | Not applicable | Enrolling by invitation | Stony Brook University | 20 | 2025-11-17 | 2026-07-22 |
| Transcutaneous Auricular Vagus Nerve Stimulation and Quality of Recovery After Major Noncardiac Surgery Transcutaneous auricular vagus nerve stimulation, Sham stimulation - Vagus Nerve Stimulation, Transcutaneous Electric Nerve Stimulation | Not applicable | Recruiting | Peking University First Hospital | 320 | 2025-05-13 | 2025-06-03 |
| Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease Active RAVANS, Sham RAVANS - Parkinson Disease, Apathy | Not applicable | Recruiting | Anhui Medical University | 60 | 2025-05-01 | 2025-11-19 |
| Rehabilitation Paired with VNS for Motor Function Recovery Active-VNS, Sham VNS - Spontaneous Intracerebral Hemorrhage, Motor Function | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 10 | 2025-04-01 | 2025-03-26 |
| Effect of Vagus Nerve Stimulation Via the Outer Ear on Motor and Cognitive Deficits After Ischemic Stroke transcutaneous auricular vagus nerve stimulation, sham-stimulation - Ischemic Stroke, Motor Deficits | Not applicable | Not yet recruiting | Rheinburg-Klinik | 144 | 2025-04-01 | 2025-02-19 |
| Vagal Stimulation in Individuals With Stroke vagus nerve stimulation, classic rehabilitation - Stroke, Vagus Nerve Stimulation | Not applicable | Active not recruiting | Nermin KART | 34 | 2025-02-25 | 2026-09-16 |
| The ENHANCE Study: taVNS and Psilocybin Psilocybin, Transcutaneous auricular Vagus Nerve Stimulation (taVNS), Psychosocial Support Alone - Healthy, Psychedelic Experiences | Phase 1 | Recruiting | University of Wisconsin, Madison | 115 | 2025-01-27 | 2026-10-20 |
| Transcutaneous Auricular Vagus Nerve Stimulation Prevents Postoperative Delirium in Elderly Patients transauricular auricular vagus nerve stimulation - Vagus Nerve Stimulation | Not applicable | Recruiting | Beijing Tiantan Hospital | 1776 | 2024-06-20 | 2025-04-25 |
| Transauricular Vagus Nerve Stimulation Improves Postoperative Sleep Disorders in Elderly Patients. Transauricular Vagal Nerve Stimulation - Vagus Nerve Stimulation | Not applicable | Completed | Beijing Tiantan Hospital | 164 | 2024-06-20 | 2026-10-07 |
| Transauricular Vagal Nerve Stimulation Improves Postoperative Delirium in Elderly Patients Transauricular Vagal Nerve Stimulation - Vagus Nerve Stimulation | Not applicable | Unknown | Beijing Tiantan Hospital | 150 | 2024-05-21 | 2024-07-03 |
| Effect Of Robotic Rehabilitation And Vagus Nerve Stimulation In Ischemia Stroke Patients Robotic Rehabilitation, Transcutaneous Auricular Vagal Nerve Stimulation - Ischemic Stroke, Vagus Nerve Stimulation | Not applicable | Unknown | SEFA HAKTAN HATIK | 40 | 2024-05-10 | 2024-04-24 |
| Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding Transcutaneous vagal nerve stimulation - Vagus Nerve Stimulation | Completed | University of California, San Francisco | 160 | 2024-02-17 | 2025-05-04 | |
| Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus Transcutaneous Vagus Nerve Stimulation Paired with Tailor-Made Notched Music Therapy, Tailor-made Notched Music Training - Tinnitus, Subjective, Vagus Nerve Stimulation | Not applicable | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 388 | 2023-11-23 | 2023-11-27 |
| Safety and Efficacy Study of Implantable Neuromodulation for Poststroke Hemiplegia The DBS electrodes are implanted into MLR., The electrodes are implanted into the patient's vagus nerve - Stroke Sequelae, Deep Brain Stimulation | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 98 | 2023-11-10 | 2023-11-08 |
| Comparison of Effectiveness In-ear and Behind-ear Vagus Nerve Stimulation Transcutaneous Vagus Nerve Stimulation - Vagus Nerve Stimulation | Not applicable | Completed | Bahçeşehir University | 76 | 2023-09-15 | 2024-03-15 |
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Stroke (4) · Cognitive Dysfunction (2) · Ischemic Stroke (2) · Abdominal Pain (1) · Acute Coronary Syndrome (1) · Agnosia (1) · Alcoholism (1) · Arm Injuries (1) · Atrial Fibrillation (1) · Auditory Diseases, Central (1) · Auditory Perceptual Disorders (1) · Body Weight (1) · Coronary Disease (1) · Delirium (1) · Depression (1)
Pathological Conditions, Signs and Symptoms (13) · Nervous System Diseases (11) · Signs and Symptoms (11) · Brain Diseases (8) · Central Nervous System Diseases (8) · Neurologic Manifestations (8) · Cardiovascular Diseases (7) · Vascular Diseases (7) · Cerebrovascular Disorders (6) · Mental Disorders (5) · Neurobehavioral Manifestations (4) · Behavior (3) · Behavioral Symptoms (3) · Cognition Disorders (3) · Neurocognitive Disorders (3)
Transcutaneous Electric Nerve Stimulation (2) · Vagus Nerve Stimulation (2) · Acetylcysteine (1) · Low-Level Light Therapy (1) · Mindfulness (1) · Psilocybin (1) · Psychiatric Rehabilitation (1)
Beijing Tiantan Hospital (4) · Bahçeşehir University (3) · Bakulev Scientific Center of Cardiovascular Surgery (2) · Medical University of South Carolina (2) · SEFA HAKTAN HATIK (2) · Anhui Medical University (1) · Chinese PLA General Hospital (1) · First Affiliated Hospital of Fujian Medical University (1) · Indiana University (1) · Istanbul Gelisim University (1) · Maastricht University Medical Center (1) · Medipol University (1) · National Medical Research Center for Therapy and Preventive Medicine (1) · Nermin KART (1) · Northwell Health (1)
United States (11) · China (7) · Turkey (Türkiye) (6) · Russia (3) · Germany (1) · Netherlands (1) · Switzerland (1)
Dorothea Jenkins, MD (2) · Ali Veysel Ozden (1) · Bashar Badran, PhD (1) · Brooke A Ammerman, PhD (1) · Charles Hogue, MD (1) · Charles Raison, MD (1) · Collet Jean-Paul, MD, Phd (1) · D. Keszthelyi (1) · Dong-Xin Wang, MD, PhD (1) · Ernesto P Molmenti, MD PhD MBA (1) · Fuxin Lin (1) · Kai Wang, Ph.D. (1)
PMID 11835542, PMID 17081672, PMID 26831988, PMID 30146041, PMID 31417453, PMID 32256328, PMID 32289710, PMID 33839137, PMID 35134082, PMID 37329979, PMID 37528897, PMID 37867315, PMID 39384245, PMID 40142674, PMID 40447430, PMID 41566492, PMID 41742071
P20GM109040 (2), P2CHD086844 (1), U24AG072699 (1)