76 completed. 76 Phase 1, 24 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 76 | Completed 76 |
| Phase 2 | 24 | Completed 24 |
Follow Type 1 Diabetes: new trials by email Literature Review of Type 1 Diabetes trials Research Report on Type 1 Diabetes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500 Portal Insulin U-500, Humulin R U-500, Lyumjev U-100 Insulin - Type 1 Diabetes | Phase 1 | Completed | Portal Diabetes, Inc. | 29 | 2026-02-10 | 2026-11-04 |
| R-5280 in Newly Diagnosed Patients With Type 1 Diabetes R-5280, Placebo - Type 1 Diabetes, Type 1 Diabetes (Juvenile Onset) | Phase 1 | Completed | Rise Therapeutics LLC | 9 | 2023-12-05 | 2025-11-10 |
| A Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes CT-868, Placebo, Victoza - Type 1 Diabetes | Phase 1 | Completed | Carmot Therapeutics, Inc. | 32 | 2023-03-21 | 2024-12-27 |
| Acetazolamide in Persons With Type 1 Diabetes - Dose Finding Acetazolamide - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | University of California, San Diego | 12 | 2023-03-20 | 2025-05-15 |
| A Trial Comparing the Pharmacodynamics and Pharmacokinetics of BC Combo THDB0207 and Lantus® and Humalog® in Subjects With Type 1 Diabetes Euglycemic clamp with BC Combo THDB0207, Euglycemic clamp with Lantus®, Euglycemic clamp with Humalog® - Type 1 Diabetes | Phase 1 | Completed | Adocia | 30 | 2022-05-12 | 2023-09-15 |
| A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes Glucagon Nasal Powder [Baqsimi] - Type 1 Diabetes | Phase 1 | Completed | Eli Lilly and Company | 7 | 2022-03-24 | 2024-05-23 |
| Device-Less Technique in Islet Transplantation Implantation of Nylon catheter (Device-less sentinel unit) - Type 1 Diabetes | Phase 1 | Completed | University of Alberta | 5 | 2022-03-22 | 2025-03-20 |
| Evaluating the Benefits of Physiologic Insulin Delivery Ultra-rapid insulin - Type 1 Diabetes | Phase 1 | Completed | Stanford University | 16 | 2021-11-01 | 2024-10-01 |
| Evaluate Safety of Adipose Derived Mesenchymal Stem Cell Transplantation for Type 1 Diabetes Treatment adipose-derived messenchymal stem cell - Type 1 Diabetes | Phase 1 | Completed | Vinmec Research Institute of Stem Cell and Gene Technology | 10 | 2021-05-04 | 2025-08-17 |
| Combination GRA and SGLT-2i Treatment in Type 1 Diabetes Dapagliflozin 10 MG [Farxiga], REMD-477, Placebo - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | University of California, San Diego | 12 | 2021-02-22 | 2023-01-23 |
| Low Dose Empagliflozin in Adults With Type 1 Diabetes on Closed Loop Insulin System 14-day outpatient intervention - Type 1 Diabetes | Phase 1 | Completed | McGill University | 25 | 2020-11-02 | 2022-10-12 |
| A Trial to Compare BioChaperone Insulin Lispro Formulations With US Approved Humalog® and With EU Approved Humalog® in Patients With Type 1 Diabetes Mellitus Administration of BioChaperone insulin lispro reconstituted with Humalog® (IMP1), Administration of Ready-to-use BioChaperone insulin lispro (IMP2), Administration of US-approved Humalog® (IMP3) - Type 1 Diabetes | Phase 1 | Completed | Adocia | 32 | 2020-08-03 | 2020-11-30 |
| Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function Acetylated and Butyrylated High Amylose Maize Starch - Type 1 Diabetes | Phase 1 | Completed | Indiana University | 12 | 2020-06-22 | 2024-10-01 |
| SGLT2 Inhibitor Adjunctive Therapy to Closed Loop Control in Type 1 Diabetes Mellitus Empagliflozin + Control-IQ x 4 wks then Basal-IQ x 2 wks, Empagliflozin + Basal-IQ x 2 wks then Control-IQ x 4 wks, No Empagliflozin + Control-IQ x 4 wks then Basal-IQ x 2 wks - Type 1 Diabetes | Phase 1 | Completed | Ananda Basu, MD | 34 | 2020-02-24 | 2022-08-11 |
| Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes Co-transplantation of PTG with pancreatic islets - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | Peter Stock | 4 | 2019-07-01 | 2026-03-06 |
| A Bioequivalence Study Comparing Two Different Strengths Formulations of Insulin Lispro in Patients With Type 1 Diabetes Insulin Lispro SAR342434 - Type 1 Diabetes | Phase 1 | Completed | Sanofi | 90 | 2019-03-26 | 2025-09-24 |
| Comparison of Exposure and Activity of SAR341402 Mix 70/30 to NovoLog Mix 70/30, NovoMix 30 and SAR341402 Rapid-acting Solution in Patients With Type 1 Diabetes Mellitus SAR341402, Insulin Aspart - Type 1 Diabetes | Phase 1 | Completed | Sanofi | 52 | 2017-12-13 | 2022-04-25 |
| Enhanced Epidermal Antigen Specific Immunotherapy Trial -1 C19-A3 GNP - Type 1 Diabetes | Phase 1 | Completed | Cardiff University | 6 | 2016-09-29 | 2023-03-31 |
| Tandem Predictive Low Glucose Suspend Inpatient Feasibility Study t:slim insulin pump with predictive low glucose suspend - Diabetes Mellitus, Type 1 Diabetes | Phase 1 | Completed | Tandem Diabetes Care, Inc. | 10 | 2016-08-01 | 2016-09-01 |
| Omental Islet Transplant Omental Islet transplant, Anti-Thymocyte Globulin, Mycophenolate mofetil - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | University of Alberta | 4 | 2016-05-01 | 2022-05-09 |
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Diabetes Mellitus, Type 1 (76) · Diabetes Mellitus (16) · Hypoglycemia (8) · Insulin Resistance (5) · Hyperglycemia (2) · Diabetes Mellitus, Type 2 (1) · Enterovirus Infections (1) · Obesity (1) · Overweight (1) · Prediabetic State (1) · Unconsciousness (1) · alpha 1-Antitrypsin Deficiency (1)
Autoimmune Diseases (76) · Endocrine System Diseases (76) · Glucose Metabolism Disorders (76) · Immune System Diseases (76) · Metabolic Diseases (76) · Nutritional and Metabolic Diseases (76) · Diabetes Mellitus (60) · Hyperinsulinism (5) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (2) · Body Weight (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Consciousness Disorders (1) · Digestive System Diseases (1) · Emphysema (1)
Insulin Lispro (5) · Insulin Aspart (3) · Sodium Chloride (3) · aldesleukin (3) · Continuous Glucose Monitoring (2) · Etanercept (2) · Hematologic Tests (2) · Insulin (2) · Interleukin-2 (2) · Islets of Langerhans Transplantation (2) · Mycophenolic Acid (2) · Sirolimus (2) · dapagliflozin (2) · thymoglobulin (2) · 2,4-thiazolidinedione (1)
Sanofi (4) · University of Minnesota (4) · Medical University of Graz (3) · University of Alberta (3) · Adocia (2) · AstraZeneca (2) · Baylor Research Institute (2) · Cambridge University Hospitals NHS Foundation Trust (2) · Cardiff University (2) · Diatranz Otsuka Limited (2) · Indiana University (2) · Jaeb Center for Health Research (2) · Ospedale San Raffaele (2) · Stanford University (2) · University of California, San Diego (2)
United States (42) · Germany (7) · Canada (6) · United Kingdom (6) · Austria (4) · Israel (3) · Italy (3) · France (2) · Argentina (1) · China (1) · New Zealand (1) · Switzerland (1) · Vietnam (1)
Bernhard J. Hering, M.D. (2) · Howard Zisser, MD (2) · Lorenzo Piemonti, MD (2) · Michael J Haller, MD (2) · Roy W Beck, MD, PhD (2) · Thomas R Pieber, MD (2) · Ahmad Haidar, PhD (1) · Aleksandra Pastrak, M.D. (1) · Ananda Basu, MD (1) · Andrew M Posselt, M.D., Ph.D. (1) · Andrew Posselt, M.D., Ph.D. (1) · Antonio Secchi, MD (1) · Bruce Buckingham, MD (1)
PMID 14961992, PMID 15383562, PMID 15713772, PMID 16380489, PMID 17130571, PMID 19366957, PMID 21084848, PMID 22634621, PMID 23274902, PMID 23359039, PMID 23611977, PMID 24432999, PMID 24622415, PMID 25003311, PMID 25188375, PMID 25211216, PMID 25286053, PMID 25881192, PMID 25898052, PMID 26040429, PMID 26134834, PMID 26345338, PMID 27727279, PMID 28866779, PMID 30130323, PMID 30282826, PMID 30787930, PMID 30895467, PMID 31825248, PMID 32010488, PMID 32345707, PMID 32582156, PMID 32715853, PMID 33236518, PMID 33475138, PMID 34282646, PMID 35073398, PMID 35255229, PMID 35919496, PMID 37626387, PMID 37700317, PMID 37918404, PMID 39466253
2017 (1), 2018 (1), DP3DK106785 (1), K23DK122017 (1), KL2TR002530 (1), M01RR000069 (1), R01DK062440 (1), R01DK070917 (1), R01DK101984 (1), R21DK078863 (1), UL1TR002529 (1)