20 completed, 5 unknown, 4 active not recruiting, 4 terminated. 16 Phase 2, 14 Phase 1, 6 Phase 3, 4 Not applicable.
Follow Islets of Langerhans Transplantation: new trials by email Literature Review of Islets of Langerhans Transplantation trials Research Report on Islets of Langerhans Transplantation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Breakthrough - T1DM and Chronic Kidney Disease Tegoprubart, Islet Cell Transplant - Diabete Type 1, Chronic Kidney Disease | Phase 1 / Phase 2 | Recruiting | University of Chicago | 10 | 2027-04-29 | 2026-08-20 |
| Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D) Islet transplantation with Tegoprubart (AT-1501) immunosupression-based therapy - Type 1 Diabetes Mellitus | Phase 1 / Phase 2 | Active not recruiting | University of Chicago | 70 | 2024-03-04 | 2026-09-22 |
| Novel Method of Pancreatic Islet Transplantation Into the Omentum Pancreatic islet transplantation - Islets of Langerhans Transplantation | Not applicable | Unknown | Frantisek Saudek | 6 | 2019-08-15 | 2021-08-31 |
| Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant Alpha 1-Antitrypsin, Islet Transplantation, Thymoglobulin - Kidney Transplant, Type 1 Diabetes | Phase 2 | Completed | Massachusetts General Hospital | 2 | 2017-01-01 | 2023-12-22 |
| Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes Islet graft, best medical care - Type 1 Diabetes | Phase 3 | Unknown | University Hospital, Grenoble | 42 | 2016-07-07 | 2022-06-24 |
| Pancreatic Islet Transplantation in the Anterior Chamber of the Human Eye - a Pilot Study Pancreatic islet transplantation in the anterior chamber - Type 1 Diabetes Mellitus | Not applicable | Unknown | University Hospital, Basel, Switzerland | 4 | 2016-03-01 | 2024-03-29 |
| Islet Cell Transplant for Type 1 Diabetes Allogenic Human Islet Cells, Immunosuppressive Agents, Gastrin 17 - Type 1 Diabetes Mellitus | Phase 2 | Active not recruiting | City of Hope Medical Center | 10 | 2015-07-10 | 2026-10-26 |
| Nephrologic Prognosis 10 Years After Diabetes Cell Therapy islet transplanted, non islet transplanted - Islet Transplantation | Completed | University Hospital, Lille | 45 | 2014-11-03 | 2022-04-29 | |
| Allogeneic Islet Cells Transplanted Onto the Omentum Islet transplantation - Type 1 Diabetes Mellitus, Hypoglycemia | Phase 1 / Phase 2 | Completed | Rodolfo Alejandro | 3 | 2014-09-01 | 2025-08-12 |
| A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients Islet Cell Transplant - Type 1 Diabetes, Severe Hypoglycemic Unawareness | Phase 3 | Completed | Northwestern University | 10 | 2012-06-01 | 2026-06-18 |
| A Comparison of Islet Cell Transplantation With Medical Therapy for the Treatment of Diabetic Eye Disease islet cell transplant, Medical therapy - Diabetic Retinopathy, Diabetic Macular Edema | Phase 3 | Withdrawn | University of British Columbia | 2009-12-01 | 2014-03-17 | |
| Islet After Kidney Transplantation (IAK) in Patients With Type 1 Diabetes Islet Transplantation, Islet cell transplantation - Diabetes Mellitus | Phase 1 | Completed | City of Hope Medical Center | 3 | 2008-10-18 | 2026-04-27 |
| Pancreatic Islet Cell Transplantation After Kidney Transplantation - A Novel Approach to Immunosupression Islet cell transplantation - Islet Cell Transplantation, Type 1 Diabetes | Phase 1 | Withdrawn | Baylor Research Institute | 2008-07-01 | 2017-02-15 | |
| Pancreatic Islet Cell Transplantation - A Novel Approach to Improve Islet Quality and Engraftment Islet cell transplantation - Islet Cell Transplantation, Type 1 Diabetes | Phase 1 | Completed | Baylor Research Institute | 1 | 2008-07-01 | 2017-04-24 |
| Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol Islets of Langerhans transplantation - Type 1 Diabetes Mellitus | Phase 3 | Active not recruiting | CellTrans Inc. | 21 | 2007-09-05 | 2026-04-06 |
| Efficacy of Islet After Kidney Transplantation Islet transplantation, Antithymocyte Globulin, Daclizumab or Basiliximab - Type 1 Diabetes Mellitus | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 24 | 2007-01-01 | 2017-10-20 |
| UVA Islet Cell Transplantation in Patients With Type I Diabetes Pancreatic Islets of Langerhans Cell Transplant - Diabetes Mellitus, Type 1 | Phase 1 | Unknown | University of Virginia | 20 | 2007-01-01 | 2009-02-18 |
| Islet Transplantation in Type 1 Diabetes Allogeneic Pancreatic Islet Cells, Antithymocyte Globulin, Sirolimus - Type 1 Diabetes Mellitus | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 48 | 2006-10-01 | 2019-07-17 |
| Steroid-free and Long-term Calcineurin-free Trial in Islet Cell Transplantation Islet transplantation - Type 1 Diabetes Mellitus | Phase 2 | Completed | Rodolfo Alejandro | 3 | 2005-07-01 | 2017-05-25 |
| Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging ferucarbotran (iron-based MRI contrast agent), Islet transplantation, Magnetic resonance imaging - Type 1 Diabetes Mellitus | Phase 1 | Terminated | University Hospital, Geneva | 5 | 2005-06-01 | 2014-12-02 |
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Diabetes Mellitus, Type 1 (30) · Diabetes Mellitus (12) · Hypoglycemia (10) · Hyperglycemia (3) · Autoimmune Diseases (2) · Diabetic Retinopathy (1) · Metabolic Diseases (1) · Renal Insufficiency, Chronic (1)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4) · Rodolfo Alejandro (4) · Baylor Research Institute (3) · City of Hope Medical Center (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · University Hospital, Lille (3) · University of Chicago (2) · CellTrans Inc. (1) · Frantisek Saudek (1) · Massachusetts General Hospital (1) · National Center for Research Resources (NCRR) (1) · Northwestern University (1) · University Hospital, Basel, Switzerland (1) · University Hospital, Geneva (1) · University Hospital, Grenoble (1)
United States (27) · France (4) · Switzerland (4) · Canada (3) · Czechia (1) · Germany (1) · Italy (1)
Rodolfo Alejandro, M.D. (3) · Rodolfo Alejandro, MD (3) · Fouad Kandeel, MD (2) · James Shapiro, MD, PhD (2) · Jose Oberholzer, MD (2) · Ali Naji, PhD (1) · Andrew Posselt, MD, PhD (1) · Bernhard Hering, MD (1) · Camillo Ricordi, M.D. (1) · Camillo Ricordi, MD (1) · Daniel Borja-Cacho, MD (1) · David M. Thompson, MD (1) · Fouad Kandeel, MD, PhD (1) · Francois Pattou, MD (1)
PMID 19005394, PMID 20003758, PMID 22996144, PMID 23438305, PMID 25393157, PMID 28941330, PMID 31615852, PMID 39780302, PMID 15257060, PMID 15996257, PMID 17005949, PMID 18360260, PMID 18444920, PMID 19104407, PMID 19418039, PMID 19638525, PMID 20660050, PMID 23630300, PMID 25629445, PMID 27208344, PMID 27465220, PMID 28219959, PMID 29506054, PMID 29563196, PMID 29654388, PMID 29779835, PMID 39735417, PMID 39881535
M01RR000036 (1), R01DK025802 (1), R01DK055347 (1), R01DK056953 (1), U42RR016603 (1)