277 completed, 57 recruiting, 54 unknown, 45 terminated. 116 Not applicable, 101 Phase 2, 54 Phase 1, 49 Phase 3, 43 Phase 4.
Follow Emphysema: new trials by email Literature Review of Emphysema trials Research Report on Emphysema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of CTX460 in Adults With Emphysema Associated With Severe Alpha-1 Antitrypsin Deficiency (AATD) CTX460 - Alpha-1 Antitrypsin Deficiency (AATD) | Phase 1 / Phase 2 | Not yet recruiting | CRISPR Therapeutics | 68 | 2026-10-31 | 2026-09-30 |
| Natural Course and Molecular Basis of Alpha 1- Antitrypsin Deficiency-associated Liver Disease. Multi-omic spatial analysis - Alpha 1-antitrypsin Deficiency (AATD) | Not yet recruiting | Assiut University | 45 | 2026-10-01 | 2026-06-10 | |
| A Study of the Safety and Efficacy of Prime Editing (PM647a) in Participants With Alpha-1 Antitrypsin Deficiency PM647a - Alpha-1 Antitrypsin Deficiency, Alpha-1 Antitrypsin Deficiency-associated Lung Disease | Phase 1 / Phase 2 | Not yet recruiting | Prime Medicine, Inc. | 54 | 2026-10-01 | 2026-10-21 |
| Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD) CE1226 - Alpha1 Antitrypsin Deficiency, Alpha1-Proteinase Inhibitor Deficiency | Phase 4 | Recruiting | CSL Behring | 270 | 2026-09-29 | 2026-10-16 |
| Lung Disease and FLNA Mutations Radiation: Chest HRCT - Emphysema | Not applicable | Not yet recruiting | University Hospital, Lille | 70 | 2026-09-01 | 2026-05-26 |
| A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) Brenipatide, Placebo, Standard of Care - Pulmonary Disease, Chronic Obstructive | Phase 2 | Recruiting | Eli Lilly and Company | 606 | 2026-08-07 | 2026-10-08 |
| DIVision of the Interlobar Fissure in Patients Who Do Not Respond to Endobronchial Lung Volume Reduction Surgical Lung Fissure Division - Chronic Obstructive Pulmonary Disease (COPD), Emphysema | Not applicable | Not yet recruiting | Rocco Bilancia | 15 | 2026-08-01 | 2026-07-02 |
| IBS-Oriented CDED Versus Low FODMAP Diet for Irritable Bowel Syndrome Modified Crohn's Disease Exclusion Diet (CDED), Low FODMAP Diet - Irritable Bowel Syndrome (IBS) | Not applicable | Not yet recruiting | Ariel University | 150 | 2026-07-07 | 2026-07-16 |
| Improve Muscle Weakness in Patient With COPD Aerobic Exercise Combined with Blood Flow Restriction, Aerobic exercise - Emphysema or COPD | Not applicable | Withdrawn | Al-Zaytoonah University of Jordan | 2026-06-10 | 2026-10-21 | |
| A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD) Alpha-1 15%, Liquid Alpha1-PI - Alpha 1 Antitrypsin Deficiency | Phase 3 | Recruiting | Grifols Therapeutics LLC | 40 | 2026-05-05 | 2026-08-11 |
| A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD) TSRA-196 - Alpha-1 Antitrypsin Deficiency (AATD) | Phase 1 / Phase 2 | Recruiting | Tessera Therapeutics, Inc. | 72 | 2026-04-21 | 2026-09-24 |
| Ventilation-Perfusion Discrepancy Index Versus Conventional Anatomic-Physiologic Assessment for Target Lung Lobe Selection in Endobronchial Valve Placement: A Multicenter, Randomised Controlled Trial VQDI-assisted target lung lobe selection strategy, Conventional target lung lobe selection strategy - Emphysema | Not applicable | Not yet recruiting | China-Japan Friendship Hospital | 285 | 2026-04-01 | 2026-02-11 |
| A Multi Center Study Testing a New Implant for Adults With Severe Emphysema Implantable Artificial Bronchus - Emphysema or COPD, Emphysema | Not applicable | Recruiting | Pulmair Medical, Inc. | 60 | 2026-03-25 | 2026-10-14 |
| A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD) AIR-001 SAD dose level 1, AIR-001 SAD dose level 2, AIR-001 SAD dose level 3 - Alpha 1 Antitrypsin Deficiency | Phase 1 | Recruiting | AIRNA Corporation | 54 | 2026-03-17 | 2026-10-06 |
| Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency Alpha-1-antitrypsin Deficiency, Emphysema | Recruiting | University Hospital, Bordeaux | 230 | 2026-02-16 | 2026-07-20 | |
| A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema Implantable pulmonary stent - COPD, Emphysema | Not applicable | Recruiting | Pulmair Medical, Inc. | 20 | 2026-02-04 | 2026-06-03 |
| Prevalence of Alpha-1 Antitrypsin Deficiency in Non-Cirrhotic Liver Cancer multiplex digital PCR - Retrospective Cohort of Patients Diagnosed With HCC on Non-Cirrhotic Liver | Not yet recruiting | University Hospital, Bordeaux | 71 | 2026-01-01 | 2026-01-05 | |
| Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD Multidisciplinary clinic evaluation, COPD standard of care - COPD, Emphysema | Not applicable | Recruiting | The Cleveland Clinic | 80 | 2025-10-10 | 2025-10-30 |
| Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency 20-valent pneumococcal conjugate vaccine - Alpha 1-Antitrypsin, COPD | Phase 4 | Recruiting | University of Alabama at Birmingham | 30 | 2025-09-03 | 2025-11-10 |
| COPD Resources, Education, and Activity Designed for You Study Education (self-guided), Education (counselor-led), Physical Activity - COPD | Not applicable | Recruiting | Rush University Medical Center | 448 | 2025-08-18 | 2026-10-08 |
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Pulmonary Disease, Chronic Obstructive (310) · alpha 1-Antitrypsin Deficiency (139) · Bronchitis, Chronic (84) · Lung Diseases (43) · Pulmonary Emphysema (33) · Bronchitis (22) · Asthma (17) · Lung Diseases, Obstructive (16) · Pulmonary Fibrosis (16) · Cystic Fibrosis (13) · Respiratory Tract Diseases (13) · Lung Diseases, Interstitial (12) · Lung Neoplasms (11) · Bronchiectasis (9)
Pathological Conditions, Signs and Symptoms (494) · Pathologic Processes (487) · Respiratory Tract Diseases (431) · Lung Diseases (398) · Disease Attributes (321) · Chronic Disease (320) · Lung Diseases, Obstructive (305) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (148) · Digestive System Diseases (145) · Genetic Diseases, Inborn (138) · Subcutaneous Emphysema (136) · Liver Diseases (135) · Bronchial Diseases (118) · Infections (113)
alpha 1-Antitrypsin (26) · Formoterol Fumarate (18) · Pneumonectomy (15) · aclidinium bromide (13) · Blood Specimen Collection (7) · Mp alpha1 receptor (7) · Tiotropium Bromide (7) · Acetazolamide (5) · Fluticasone (5) · Exercise (4) · Salmeterol Xinafoate (4) · Sildenafil Citrate (4) · Albuterol (3) · Educational Status (3) · GSK573719 (3)
Aeris Therapeutics (17) · AstraZeneca (16) · Grifols Therapeutics LLC (12) · National Heart, Lung, and Blood Institute (NHLBI) (11) · University Medical Center Groningen (11) · University of Zurich (10) · Boston Scientific Corporation (9) · GlaxoSmithKline (9) · Pulmonx Corporation (9) · Baxalta now part of Shire (8) · University of Pittsburgh (8) · Columbia University (7) · Olympus Corporation of the Americas (7) · Weill Medical College of Cornell University (7) · Imperial College London (6)
United States (224) · Germany (69) · United Kingdom (66) · Netherlands (45) · Canada (44) · France (34) · Spain (29) · Australia (27) · Austria (25) · Italy (23) · Sweden (22) · Denmark (21) · Ireland (20) · New Zealand (20) · Poland (20)
Esther Garcia, MD (11) · Konrad E Bloch, MD (8) · Charlie Strange, MD (7) · Dirk-Jan Slebos, MD PhD (7) · Gerard Criner, MD (7) · Talant M Sooronbaev, MD (6) · Louise E Donnelly, PhD (5) · Mark Brantly, MD (5) · Roberto P Benzo (4) · Mark Gotfried, MD (3) · Narinder Shargill, PhD (3) · Ronald G Crystal, MD (3) · Terence R. Flotte, MD (3)
PMID 34256305, PMID 19179484, PMID 22374920, PMID 33590989, PMID 18684848, PMID 20368443, PMID 21424325, PMID 22075481, PMID 22459779, PMID 22634621, PMID 22654006, PMID 22927751, PMID 25321447, PMID 25418910, PMID 26026936, PMID 26233481, PMID 26836895, PMID 27168432, PMID 27462120, PMID 27564413, PMID 28558833, PMID 29313714, PMID 29373977, PMID 30237305, PMID 30429371, PMID 31827323, PMID 32071149, PMID 36001294, PMID 39269427, PMID 39515624, PMID 39756820, PMID 40268239, PMID 40387356, PMID 42852919, PMID 10680096, PMID 10737279, PMID 10988213, PMID 11112130, PMID 11328918, PMID 11463604, PMID 11914989, PMID 12324669, PMID 12406835, PMID 12648974, PMID 12970040, PMID 14760160, PMID 14982513, PMID 14985567, PMID 15115866, PMID 15155777
2017 (5), 2023 (4), 2025 (3), R01HL069877 (3), 2009 (2), 2018 (2), 2019 (2), R01HL090339 (2), R01HL093081 (2), R01HL130883 (2), U01DK062436 (2), U01DK062445 (2), U01DK062452 (2), U01DK062453 (2), U01DK062456 (2)