13 completed, 2 not yet recruiting, 1 recruiting. 5 Phase 3, 4 Not applicable, 2 Phase 2, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 5 |
| Not applicable | 4 | Not yet recruiting 2, Completed 1, Recruiting 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
Follow Yaws: new trials by email Literature Review of Yaws trials Research Report on Yaws
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Maitland Mobilization With and Without Stroking Release Technique of Rotator Cuff Muscle in Frozen Shoulder Maitland mobilization combined with Stroking release technique, Maitland Mobilization, along with baseline treatment - Adhesive Capsulitis | Not applicable | Recruiting | Riphah International University | 44 | 2026-05-01 | 2026-10-02 |
| Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers A mobile app with AI functionality for diagnosing skin-related NTDs - Skin and Connective Tissue Diseases, Neglected Tropical Diseases | Not applicable | Not yet recruiting | Kenya Medical Research Institute | 2420 | 2026-05-01 | 2026-04-02 |
| Integrating Mental Health Into Neglected Tropical Disease Care in Ghana WHO Essential Care package for mental health and NTDs - Leprosy, Lymphatic Filariases | Not applicable | Not yet recruiting | Liverpool School of Tropical Medicine | 200 | 2025-11-01 | 2025-11-25 |
| Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws) Linezolid Oral Tablet, Azithromycin Oral Tablet - Yaws, Cutaneous Ulcer | Phase 3 | Completed | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 383 | 2023-03-14 | 2026-10-22 |
| Evaluation of a LAMP Assay for T. Pallidum. Pertenue PCR, LAMP - Yaws | Completed | London School of Hygiene and Tropical Medicine | 563 | 2021-03-15 | 2025-03-24 | |
| The Effects of Using an Interactive Game With Virtual Reality for Children During Intravenous Placement Virtual reality, Photo book - Pian, Fear | Not applicable | Completed | National Yang Ming Chiao Tung University | 134 | 2020-06-05 | 2020-09-22 |
| An Accessible Low-cost Plant Treatment for Cutaneous Ulcers Topical antiseptic treatment - Yaws; Cutaneous, Cutaneous Ulcer | Phase 2 | Completed | Oriol Mitja | 150 | 2019-11-01 | 2020-09-03 |
| Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Albendazole on Day 1, Ivermectin on Day 1, Diethylcarbamazine on day 1 - Trachoma, Yaws | Phase 3 | Completed | Lihir Medical Centre | 20000 | 2018-10-01 | 2019-02-28 |
| PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) Azithromycin, Albendazole, Ivermectin - Lymphatic Filariasis, Yaws | Phase 2 | Completed | Lihir Medical Centre | 42 | 2018-09-01 | 2019-02-28 |
| Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia Leprosy, Buruli Ulcer | Completed | London School of Hygiene and Tropical Medicine | 56285 | 2018-06-14 | 2024-06-10 | |
| Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication R1-Total community treatment with azithromycin, R2-Total community treatment with azithromycin, R3-Total community treatment with azithromycin - Yaws | Phase 4 | Completed | Lihir Medical Centre | 56000 | 2018-04-16 | 2021-06-23 |
| Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Ivermectin, Azithromycin, Permethrin - Scabies, Yaws | Phase 4 | Completed | London School of Hygiene and Tropical Medicine | 1291 | 2016-07-01 | 2019-09-17 |
| Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Azithromycin - Yaws | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 583 | 2015-06-01 | 2018-10-31 |
| Dual Point-of-care Test for the Diagnosis of Yaws Yaws | Completed | Oriol Mitja | 703 | 2013-04-01 | 2014-11-18 | |
| Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Azithromycin - Yaws | Phase 3 | Completed | Lihir Medical Centre | 16000 | 2013-03-01 | 2017-08-28 |
| Single-dose Azithromycin for the Treatment of Yaws Penicillin-G-benzathine, Azithromycin - Yaws, Treponema Infection | Phase 3 | Completed | Lihir Medical Centre | 255 | 2010-09-01 | 2012-04-13 |
Elephantiasis, Filarial (5) · Buruli Ulcer (3) · Leprosy (3) · Neglected Diseases (3) · Scabies (3) · Onchocerciasis (2) · Skin Ulcer (2) · Bursitis (1) · Disease (1) · Elephantiasis (1) · Impetigo (1) · Leishmaniasis, Cutaneous (1) · Mycetoma (1) · Pain (1)
Bacterial Infections (16) · Bacterial Infections and Mycoses (16) · Gram-Negative Bacterial Infections (16) · Infections (16) · Skin Diseases (16) · Skin Diseases, Bacterial (16) · Skin Diseases, Infectious (16) · Spirochaetales Infections (16) · Skin and Connective Tissue Diseases (15) · Treponemal Infections (15) · Parasitic Diseases (6) · Filariasis (5) · Helminthiasis (5) · Hemic and Lymphatic Diseases (5) · Lymphatic Diseases (5)
Azithromycin (8) · Ivermectin (3) · Albendazole (2) · Diethylcarbamazine (2) · Linezolid (1) · Mental Health (1) · Penicillin G (1) · Penicillin G Benzathine (1) · Permethrin (1)
Lihir Medical Centre (5) · London School of Hygiene and Tropical Medicine (4) · Oriol Mitja (2) · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (1) · Kenya Medical Research Institute (1) · Liverpool School of Tropical Medicine (1) · National Yang Ming Chiao Tung University (1) · Riphah International University (1)
Papua New Guinea (9) · Ghana (2) · Cameroon (1) · Côte d’Ivoire (1) · Democratic Republic of the Congo (1) · Ethiopia (1) · Kenya (1) · Liberia (1) · Nigeria (1) · Pakistan (1) · Senegal (1) · Solomon Islands (1) · Taiwan (1) · United Kingdom (1)
Camila Beiras (1) · David Mabey (1) · Gustavo H Penaloza, PhD (1) · Karsor Kollie, MSc (1) · Lucy John, MD (1) · Michael Marks (1) · Muhammad Umar Hasnain, MS (1) · Oriol Mitja, MD, PhD (1) · Quique Bassat, MD, PhD (1) · Rachel L Pullan, PhD (1)
PMID 22240407, PMID 25103395, PMID 25693010, PMID 29107621, PMID 29428183, PMID 29456191, PMID 29985978, PMID 32818264, PMID 34986286, PMID 35351731, PMID 37262040, PMID 42848323