10 not yet recruiting, 6 completed, 5 recruiting, 2 unknown. 9 Not applicable, 3 Phase 4, 2 Phase 2, 1 Phase 1, 1 Phase 3.
Follow Traumatic Brain Injuries: new trials by email Literature Review of Traumatic Brain Injuries trials Research Report on Traumatic Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doppler Ultrasonography Parameters and Mortality in Traumatic Brain Injury Transcranial and Carotid Doppler Ultrasonography - Traumatic Brain Injuries, Brain Injuries,Traumatic | Not yet recruiting | Inonu University | 110 | 2026-10-15 | 2026-10-22 | |
| Therapeutic Benefits of Pareidolia in Acute Traumatic Brain Injury Patients Therapeutic Benefits of Pareidolia, Active Comparator #1 - Traumatic Brain Injuries | Not applicable | Not yet recruiting | Shirley Ryan AbilityLab | 50 | 2026-10-10 | 2026-10-09 |
| PIRe 2.0: A Stepped-Care Model for Involving Relatives Across Sectors Supportive Care - Brain Injuries, Acute, Brain Tumor Adult | Not applicable | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 160 | 2026-10-01 | 2026-05-19 |
| Anti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein Complex Magnesium sulfate (MgSO4), Normal Saline - Traumatic Brain Injuries | Phase 4 | Not yet recruiting | Assiut University | 64 | 2026-10-01 | 2026-08-13 |
| Impact of Dexmedetomidine Versus Propofol on Intracranial Pressure in Adult Traumatic Brain Injury Patients: Randomized Controlled Double-Blind Trial Propofol, Dexmedetomidine - Traumatic Brain Injuries | Phase 4 | Not yet recruiting | Assiut University | 80 | 2026-10-01 | 2026-09-10 |
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| TCD and ONSD for Noninvasive Assessment of Increased ICP in TBI Transcranial Doppler (TCD), Optic Nerve Sheath Diameter (ONSD) Ultrasound - Intracranial Pressure Increase, Traumatic Brain Injuries | Active not recruiting | Ain Shams University | 40 | 2026-06-07 | 2026-09-11 | |
| Effectiveness of a Customized Digital Platform to Increase Coordination of Care and Uptake of Evidence-based Practices The intervention will be the BRILLIANT Platform, an online platform which provides five Modules aimed at increasing coordination of care and direct rehabilitation time - Aquired Brain Injury, Traumatic Brain Injuries | Not applicable | Not yet recruiting | Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal | 962 | 2025-09-30 | 2025-08-28 |
| Point of Care Testing in Emergency Departments After Mild Traumatic Brain Injury Injuries, Head, Traumatic Brain Injuries | Not yet recruiting | Cambridge University Hospitals NHS Foundation Trust | 400 | 2025-09-01 | 2025-08-19 | |
| Tidal Model Nursing for TBI Caregivers Tidal Model Based Nursing - Traumatic Brain Injuries, Caregivers | Not applicable | Completed | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | 18 | 2025-08-01 | 2026-04-02 |
| Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial) Phenytoin, Levetiracetam, Placebo - Seizures, Traumatic Brain Injuries | Phase 4 | Recruiting | All India Institute of Medical Sciences, Jodhpur | 1260 | 2025-07-23 | 2026-10-29 |
| Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury Decompressive Craniectomy, Expansion Craniotomy - Traumatic Brain Injuries, Intracranial Hypertension | Not yet recruiting | Meditech Foundation | 292 | 2025-07-08 | 2025-05-08 | |
| Security and Effectiveness Assessment of Locking Systems in Ventriculostomy for Traumatic Brain Injury Ventriculostomy, Ventriculostomy + Locking Device - Traumatic Brain Injuries, Intracranial Hypertension | Not yet recruiting | Meditech Foundation | 292 | 2025-07-05 | 2025-05-08 | |
| Walking With Overground Robotic Exoskeletons to Improve Arrousal in Individuals With Disorders of Consciousness Overground Walking - Traumatic Brain Injuries | Phase 2 / Phase 3 | Not yet recruiting | Craig Hospital | 25 | 2025-03-20 | 2025-02-24 |
| Validation and Standardisation of a "Neuralix" Digital Ecological Battery Traumatic Brain Injuries | Recruiting | Direction Centrale du Service de Santé des Armées | 800 | 2025-03-11 | 2026-08-28 | |
| Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study Tendon lengthening surgery, BoNT Injections - Muscle Spasticity, Spinal Cord Injury | Not applicable | Recruiting | Vastra Gotaland Region | 30 | 2025-01-07 | 2025-09-17 |
| Recovery Trajectory for Coma and Disorders of Consciousness Coma, Disorders of Consciousness | Recruiting | University of California, San Francisco | 2000 | 2023-09-26 | 2026-06-02 | |
| Standard Craniectomy Against Laparotomy for the Treatment of Traumatic Rise in Intracranial Pressure and the Effect on Long-term Outcome Decompressive Laparotomy, Decompressive Craniectomy - Traumatic Brain Injuries | Not applicable | Unknown | Technical University of Munich | 100 | 2022-10-01 | 2023-05-16 |
| Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Severe Traumatic Brain Injury Proprioceptive stimulations, Sham stimulations - Traumatic Brain Injuries | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 50 | 2021-10-20 | 2021-10-27 |
| Mortality in Brain Injury at the Intensive Care Unit (TraVi II) Risk factor present - Traumatic Brain Injuries | Completed | Hospital Departamental de Villavicencio | 80 | 2019-01-01 | 2025-01-15 |
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Brain Injuries, Traumatic (24) · Brain Injuries (4) · Intracranial Hypertension (3) · Stroke (3) · Brain Concussion (2) · Consciousness Disorders (2) · Muscle Spasticity (2) · Spinal Cord Injuries (2) · Anxiety Disorders (1) · Brain Neoplasms (1) · Cardiovascular Diseases (1) · Caregiver Burden (1) · Cerebral Palsy (1) · Cognition Disorders (1) · Coma (1)
Brain Diseases (24) · Central Nervous System Diseases (24) · Nervous System Diseases (24) · Trauma, Nervous System (24) · Craniocerebral Trauma (23) · Wounds and Injuries (23) · Brain Injuries (20) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Neurologic Manifestations (6) · Mental Disorders (5) · Cerebrovascular Disorders (4) · Vascular Diseases (4) · Behavior (3) · Cardiovascular Diseases (3)
Decompressive Craniectomy (2) · Dexmedetomidine (1) · Levetiracetam (1) · Magnesium Sulfate (1) · Palliative Care (1) · Phenytoin (1) · Propofol (1) · Saline Solution (1) · Surveys and Questionnaires (1) · Ultrasonography (1) · Ultrasonography, Doppler, Transcranial (1) · Ventriculostomy (1)
Assiut University (2) · Meditech Foundation (2) · Ain Shams University (1) · All India Institute of Medical Sciences, Jodhpur (1) · Assistance Publique - Hôpitaux de Paris (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Centre d'Investigation Clinique et Technologique 805 (1) · Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (1) · Copenhagen University Hospital, Rigshospitalet (1) · Craig Hospital (1) · Direction Centrale du Service de Santé des Armées (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Gaziler Physical Medicine and Rehabilitation Education and Research Hospital (1) · Hospital Departamental de Villavicencio (1) · Inonu University (1)
United States (5) · France (4) · Turkey (Türkiye) (2) · Canada (1) · Colombia (1) · Denmark (1) · Egypt (1) · Germany (1) · India (1) · Sweden (1)
Andres M Rubiano, MD (2) · Luigi V Berra, MD (2) · Annabelle Arnould, psychologue (1) · Armando James Rotondi (1) · Claude Hemphill, MD, MAS (1) · Dr Apinderpreet Singh Additional Professor, MCh Neurosugery (1) · Dr Kamlesh Bhaisora Additional Professor, MCh Neurosugery (1) · Durga Roy, MD (1) · Frank Chang, MD (1) · Khaled M Maghawry, Professor (1) · Laura Dreer, Ph.D. (1) · Norton Perez, MD (1)
PMID 15226070, PMID 25189470, PMID 27821129, PMID 29430327, PMID 30447560, PMID 30735020, PMID 31486027, PMID 32741786, PMID 33554739, PMID 34493135, PMID 34725728, PMID 34725957, PMID 35125410, PMID 35198210, PMID 36585608, PMID 37265152, PMID 37763678, PMID 37822567, PMID 37832428, PMID 39209251, PMID 40353282
R01HD036075 (1)