24 completed, 7 unknown, 4 active not recruiting, 4 recruiting. 15 Phase 2, 9 Not applicable, 9 Phase 1, 6 Phase 3, 3 Phase 4.
Follow Toxicity: new trials by email Literature Review of Toxicity trials Research Report on Toxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neurocognitive Deficit After Paediatric Transplantation: Understanding the Role of Environment and Physical Function HSCT, Pediatric Cancer | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 100 | 2026-02-15 | 2026-02-20 | |
| Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70) Practical Geriatric Assessment, Correlation of body composition PGA and step count with outcomes - Geriatric Assessment, Advanced Cancer | Active not recruiting | Abramson Cancer Center at Penn Medicine | 150 | 2025-07-01 | 2026-09-24 | |
| Plasticizer Exposure and Its Consequences on Health Beta-thalassemia, Glioma | Not yet recruiting | Medical University of Vienna | 120 | 2024-10-01 | 2024-07-24 | |
| Feasibility of the Maastro Applicator in Rectal Cancer Maastro applicator - Rectal Cancer, Feasibility | Not applicable | Active not recruiting | Maastricht Radiation Oncology | 10 | 2024-08-27 | 2025-08-14 |
| Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases Online adaptive SBRT, Conventional SBRT - Adaptive Radiotherapy, Stereotactic Body Radiotherapy | Phase 2 | Recruiting | Sun Yat-sen University | 130 | 2024-05-22 | 2025-11-17 |
| Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer Patients CDK 4/6 inhibitors, Endocrine therapy - Metastatic Breast Cancer, Advanced Breast Cancer | Phase 3 | Recruiting | Region Örebro County | 495 | 2024-04-01 | 2024-11-19 |
| Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinoma Induction Immunotherapy-Toripalimab, Induction Chemotherapy-Albumin-paclitaxel combined with cisplatin, Radiotherapy - Esophageal Squamous Cell Carcinoma, Efficacy | Phase 2 | Completed | Sun Yat-sen University | 170 | 2024-02-15 | 2026-08-03 |
| The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study Short Chain Fatty Acid, Tapioca Flour - Toxicity, Radiation Toxicity | Phase 1 / Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 122 | 2023-12-15 | 2026-10-05 |
| Assessment of Peroxide Level in Saliva During Teeth Bleaching With 9.5% Hydrogen Peroxide Gel 9.5% hydrogen peroxide bleaching (POLA DAY advanced tooth whitening system, SDI) using a tray with reservoir, 9.5% hydrogen peroxide bleaching (POLA DAY advanced tooth whitening system, SDI) using a tray without reservoir. - Consumption, Toxicity | Not applicable | Completed | Cairo University | 34 | 2023-01-10 | 2025-01-03 |
| Apatinib With Ifosfamide Plus Etoposide for Relapsed or Refractory Osteosarcoma (OAIE) Apatinib+IE, IE - Effect of Drug, Drug | Phase 2 | Completed | Peking University People's Hospital | 81 | 2022-03-01 | 2024-07-31 |
| A Study of GFH312 in Healthy Subjects GFH312, Placebo - Toxicity, Healthy | Phase 1 | Completed | GenFleet Therapeutics (Australia) Pty Ltd. | 76 | 2021-04-27 | 2023-05-15 |
| Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project ASCAPE-based follow-up strategy - Breast Cancer, Prostate Cancer | Phase 2 | Active not recruiting | Region Örebro County | 500 | 2021-02-01 | 2024-11-19 |
| Prevention of Radiotherapy Induced Enteropathy by Probiotics (PREP) Bacillus Licheniformis, Placebo - Radiotherapy, Toxicity | Phase 3 | Unknown | Asan Medical Center | 248 | 2019-06-01 | 2021-01-19 |
| Safety Assessment of P2Et Extract in Healthy Voluntary Subjects in Colombia P2Et extract - Toxicity, Safety Issues | Phase 1 | Completed | Hospital Universitario San Ignacio | 7 | 2019-04-30 | 2024-03-13 |
| The OPTIMAL TDM Study: Determining Optimal Beta-lactam Plasma Concentrations Through Therapeutic Drug Monitoring The study is observational. - Beta-lactam Antibiotics, Therapeutic Drug Monitoring | Completed | University of Geneva, Switzerland | 771 | 2019-01-14 | 2025-05-20 | |
| The ESTxENDS Trial- Substudy on the Effect on Toxins From Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig) ENDS (Vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling - Smoking Cessation, Toxicity | Not applicable | Completed | University of Bern | 1246 | 2018-07-16 | 2023-11-15 |
| Effect of Tacrolimus Formulation on Neurological Side Effects in Older Kidney Transplant Recipients Envarsus, IR Tacrolimus - Kidney Transplant; Complications, Toxicity | Phase 4 | Completed | University of California, Davis | 64 | 2018-04-01 | 2025-04-08 |
| Apatinib Plus Anti-PD1 Therapy for Advanced Osteosarcoma Apatinib, SHR-1210 - Progression-free Survival, Overall Survival | Phase 2 | Completed | Peking University People's Hospital | 43 | 2018-01-01 | 2020-05-19 |
| Pegylated Liposomal Doxorubicin Versus Pirarubicin Plus Ifosfamide, Dacarbazine in Locally Advanced, Unresectable or Metastatic Soft-tissue Sarcoma pegylated liposomal doxorubicin, pirarubicin - Progression-free Survival, Overall Survival | Phase 2 / Phase 3 | Withdrawn | Peking University People's Hospital | 2017-11-06 | 2020-05-19 | |
| Alpha Lipoic Acid as an Adjuvant Treatment in Acute Phosphide Poisoning Alpha Lipoic Acid (Thioctacid), Placebo (for Alpha Lipoic Acid) - Toxicity | Phase 2 | Unknown | Heba Allah Ali Abd El-Halim Mabrouk | 50 | 2016-05-01 | 2016-05-10 |
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Breast Neoplasms (4) · Neoplasms (3) · Osteosarcoma (3) · Radiation Injuries (3) · Carcinoma, Non-Small-Cell Lung (2) · Drug-Related Side Effects and Adverse Reactions (2) · Lung Neoplasms (2) · Neurotoxicity Syndromes (2) · Sarcoma (2) · Arrhythmias, Cardiac (1) · Chondrosarcoma (1) · Cognition Disorders (1) · Colorectal Neoplasms (1) · Diabetes Mellitus (1) · Diarrhea (1)
Neoplasms (20) · Neoplasms by Site (13) · Pathological Conditions, Signs and Symptoms (8) · Neoplasms by Histologic Type (7) · Digestive System Diseases (6) · Pathologic Processes (6) · Digestive System Neoplasms (5) · Gastrointestinal Diseases (5) · Nervous System Diseases (5) · Breast Diseases (4) · Gastrointestinal Neoplasms (4) · Lung Diseases (4) · Neoplasms, Connective and Soft Tissue (4) · Respiratory Tract Diseases (4) · Respiratory Tract Neoplasms (4)
Carboplatin (3) · Capecitabine (2) · Cisplatin (2) · Oxaliplatin (2) · Radiotherapy (2) · apatinib (2) · (north)-methanocarbathymidine (1) · 1-((1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid (1) · 130-nm albumin-bound paclitaxel (1) · Albumin-Bound Paclitaxel (1) · Bevacizumab (1) · Blood Specimen Collection (1) · Butyric Acid (1) · Carnitine (1) · Dexmedetomidine (1)
Peking University People's Hospital (4) · Heba Allah Ali Abd El-Halim Mabrouk (2) · Region Örebro County (2) · Sun Yat-sen University (2) · University Hospital, Ghent (2) · Abramson Cancer Center at Penn Medicine (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Amsterdam UMC, location VUmc (1) · Asan Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Banner Health (1) · Cairo University (1) · Campus Bio-Medico University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Fudan University (1)
United States (8) · China (7) · Italy (4) · Netherlands (4) · Switzerland (3) · United Kingdom (3) · Austria (2) · Belgium (2) · Finland (2) · France (2) · Greece (2) · South Korea (2) · Spain (2) · Sweden (2) · Argentina (1)
Hui Liu, Professor (2) · Wei Guo, M.D.and Ph.D. (2) · Anne-Michelle Ruha, M.D. (1) · Antonios Valachis, Assoc Prof (1) · Aquilur Rahman, PhD (1) · Dan Benhamou (1) · Egbert F Smit, MD, PhD (1) · Gerd Fastner, Assoc.Prof. (1) · Giovanna Damia, PHD (1) · Hanneke WM van Laarhoven, Prof.Dr. (1) · Iman Ibrahim El Sayad, prof (1) · Jervoise Dr Andreyev, MA, Phd (1) · Jianhua Chang, MD,PhD (1) · Joel Greenberger, MD (1) · Jong Hoon Lee, MD (1)
PMID 19915187, PMID 24411228, PMID 26188037, PMID 27404223, PMID 28111294, PMID 28464906, PMID 29054923, PMID 29476349, PMID 30194205, PMID 30528370, PMID 32376724, PMID 34272204, PMID 34530750, PMID 34741815, PMID 35433441, PMID 35446854, PMID 35533793, PMID 36307826, PMID 36356279, PMID 36692475, PMID 36898361, PMID 36947036, PMID 37084629, PMID 38564692, PMID 39294452, PMID 39431459, PMID 39451742, PMID 40088865, PMID 40450795, PMID 41123568, PMID 41389716, PMID 41784985, PMID 42497369, PMID 42782098
2008 (1), 2014 (1), 2017 (1), 2018 (1), R01CA177592 (1), U10CA037420 (1), UG1CA189961 (1)