9 completed, 3 recruiting, 2 terminated. 3 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 1, Recruiting 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Torsades de Pointes: new trials by email Literature Review of Torsades de Pointes trials Research Report on Torsades de Pointes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Do QT-Prolonging Drugs Cause Major Adverse Cardiac Events in Hospitalized Adults? Acquired Long QT, Ventricular Arrhythmias | Recruiting | St. Joseph's Healthcare Hamilton | 990000 | 2025-02-01 | 2026-01-28 | |
| Effect of Hyperglycaemia and Moxifloxacin on QTc Interval in T2DM glucose, moxifloxacin - Diabetes Type 2, Hyperglycaemia (Diabetic) | Not applicable | Terminated | Richmond Pharmacology Limited | 14 | 2023-04-13 | 2026-07-01 |
| Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP) Hormone replacement therapy:effect on ventricular repolarization, ECG - Premature Ovarian Insufficiency | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2021-04-14 | 2025-12-09 |
| Clinical Cohort Study - TRUST Arrhythmias, Cardiac, Atrial Fibrillation | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 5000 | 2021-03-17 | 2025-03-30 | |
| Study of Arrhythmia and ECG Abnormalities in Patients With COVID-19 ECG data analysis, Treatment data collect, Biological check-up data collect - Arrhythmia, SARS-CoV-2 Infection | Completed | University Hospital, Bordeaux | 196 | 2020-06-02 | 2021-06-24 | |
| Safety of Short-term Hydroxychloroquine Plus Azithromycin Treatment in Critically Ill Patients With Severe COVID-19 COVID-19 | Completed | Institut Mutualiste Montsouris | 40 | 2020-03-19 | 2020-09-01 | |
| Pharmacist Use of ECG to Inform Drug Therapy Decisions for Patients Receiving QT Prolonging Medications Pharmacist Intervention - Torsades de Pointe Caused by Drug (Disorder), Torsades de Pointes | Not applicable | Completed | Northeast Iowa Medical Education Foundation | 54 | 2019-07-11 | 2020-04-09 |
| Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes Testosterone, Progesterone, Placebo - Long QT Syndrome | Phase 4 | Completed | Indiana University | 14 | 2016-05-01 | 2019-08-28 |
| Risk of QT-prolongation and Torsade de Pointes in Patients Treated With Acute Medication in a University Hospital Haloperidol, azi/clari/erythromycin, levo/moxifloxacin, co-trimoxazole, vori/keto/flu/itraconazole, methadone, tacrolimus, sunitinib - Delirium, QT-prolongation | Completed | KU Leuven | 178 | 2014-02-01 | 2015-07-28 | |
| A Registry to Determine the Clinical and Genetic Risk Factors for Torsade De Pointes Long qt Syndrome, Torsade de Pointes | Terminated | Massachusetts General Hospital | 11 | 2013-10-01 | 2021-12-03 | |
| Drug Interactions With Risk of QT-prolongation in a General Hospital Haloperidol - QT-prolongation | Completed | KU Leuven | 222 | 2013-07-01 | 2014-06-11 | |
| Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening Progesterone, Placebo, Ibutilide - Prolonged QT Interval in EKG and Sudden Death | Phase 2 | Completed | Indiana University | 19 | 2013-04-01 | 2015-10-30 |
| QT-prolongation in Psychiatric Hospitals drugs linked with QT-prolongation - QT-prolongation | Completed | KU Leuven | 152 | 2010-10-01 | 2015-07-28 | |
| A Study to Evaluate How VI-0521 Affect Cardiac Repolarization in Healthy Male and Female Volunteers VI-0521 - Torsades de Pointes | Phase 1 | Completed | VIVUS LLC | 112 | 2009-02-01 | 2010-01-21 |
Long QT Syndrome (7) · Arrhythmias, Cardiac (2) · COVID-19 (2) · Risk Reduction Behavior (2) · Arrhythmogenic Right Ventricular Dysplasia (1) · Atrial Fibrillation (1) · Atrial Flutter (1) · Brugada Syndrome (1) · Cardiovascular Diseases (1) · Delirium (1) · Diabetes Mellitus, Type 2 (1) · Hyperglycemia (1) · Jervell-Lange Nielsen Syndrome (1) · Polymorphic Catecholaminergic Ventricular Tachycardia (1)
Cardiac Conduction System Disease (14) · Heart Diseases (14) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Tachycardia (14) · Cardiovascular Diseases (13) · Tachycardia, Ventricular (13) · Arrhythmias, Cardiac (12) · Cardiovascular Abnormalities (8) · Congenital Abnormalities (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Heart Defects, Congenital (8) · Behavior (2) · Coronaviridae Infections (2) · Coronavirus Infections (2)
Haloperidol (2) · Progesterone (2) · ibutilide (2) · Drugs, Generic (1) · Electrocardiography (1) · Erythromycin (1) · Glucose (1) · Lactose (1) · Methadone (1) · Moxifloxacin (1) · Sunitinib (1) · Tacrolimus (1) · Testosterone (1) · Trimethoprim, Sulfamethoxazole Drug Combination (1)
KU Leuven (3) · Indiana University (2) · Assistance Publique - Hôpitaux de Paris (1) · Institut Mutualiste Montsouris (1) · Massachusetts General Hospital (1) · Northeast Iowa Medical Education Foundation (1) · Richmond Pharmacology Limited (1) · St. Joseph's Healthcare Hamilton (1) · University Hospital, Bordeaux (1) · Universitätsklinikum Hamburg-Eppendorf (1) · VIVUS LLC (1)
United States (5) · Belgium (3) · France (3) · Canada (1) · Germany (1) · United Kingdom (1)
Eline Vandael, PhD-student (3) · Andreas Metzner, MD (1) · Andreas Rillig, MD (1) · Anne Bachelot, Pr (1) · Anne M Holbrook (1) · Christopher Newton-Cheh, MD, MPH (1) · James E Tisdale, BSc, PharmD (1) · James E Tisdale, PharmD (1) · Joe Elie Salem, MD (1) · Paulus Kirchhof, MD (1) · Shiyin Yee, PhD (1)
PMID 28281228, PMID 33020898, PMID 37638409, PMID 40810874, PMID 41732243