35 completed, 6 unknown, 3 recruiting, 2 not yet recruiting. 46 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 46 | Completed 35, Unknown 6, Recruiting 3, Not yet recruiting 2 |
Follow Tooth Demineralization: new trials by email Literature Review of Tooth Demineralization trials Research Report on Tooth Demineralization
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Hygiene Assistance Training Program Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash - Elderly, Periodontal Disease | Phase 4 | Not yet recruiting | Colgate Palmolive | 500 | 2026-09-20 | 2026-09-08 |
| Pilot and Feasibility Study of Impact of SDF 38% Application on Oral Health of Elderly With Autonomy Loss Silver diamine Fluoride 38%, placebo solution - Dental Caries, Elderly | Phase 4 | Not yet recruiting | Université de Montréal | 60 | 2025-10-01 | 2025-09-26 |
| A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification - Dental Caries, White Spot Lesion | Phase 4 | Recruiting | Dow University of Health Sciences | 90 | 2023-12-12 | 2025-03-11 |
| Effect of Silver Diamine Fluoride Application on Oral Microbiome of Healthy Pediatric Patient Silver diamine Fluoride 38%, Silver diamine fluoride- potassium iodide - Dental Caries | Phase 4 | Recruiting | King Abdulaziz University | 50 | 2023-11-01 | 2025-03-06 |
| Fluoride Delivery to Prevent White Spots During Orthodontic Treatment Fluoride mouthwash (0.05%; 225ppm)., Tooth Mousse Plus - Orthodontic Appliance Complication, Tooth Demineralization | Phase 4 | Unknown | Liverpool University Hospitals NHS Foundation Trust | 130 | 2023-10-20 | 2023-11-08 |
| Atraumatic Versus Silver-Modified Atraumatic Restorative Treatment in Primary Molars ART: Atraumatic restorative treatment, SMART: Silver-Modified Atraumatic Restorative Treatment - Dental Caries, Dental Caries in Children | Phase 4 | Completed | Beirut Arab University | 34 | 2023-05-02 | 2025-06-17 |
| Fluoride vs Probiotic Toothpaste for Caries Prevention Fluoride toothpaste, Probiotic Toothpaste, Control Toothpaste - Dental Caries, Child Behavior | Phase 4 | Completed | The Affiliated Hospital of Qingdao University | 508 | 2023-01-01 | 2026-05-12 |
| Treatment of Early Childhood Caries Using Silver Diammine Fluoride and Sodium Fluoride Tricalciumphosphate and the Effects on Oral Health Related Quality of Life Topical application of 38% Silver Diammine Fluoride Solution, Topical application of 5% Sodium Fluoride with functional Tricalcium phosphate Varnish - Early Childhood Caries, Dental Caries in Children | Phase 4 | Unknown | Universiti Sains Malaysia | 72 | 2022-01-18 | 2023-03-16 |
| Cariostatic and Remineralizing Effects of Three Different Dental Varnishes Nano Silver Fluoride varnish, nano-hydroxyapatite varnish, sodium Fluoride Varnish - Dental Caries in Children, Cariostatic Agent | Phase 4 | Completed | Nisreen Ibrahim khan | 115 | 2021-08-01 | 2024-04-02 |
| Comparison of Silver Modified and Conventional Atraumatic Restorative Treatment Modalities Silver diamine Fluoride 38%, Conventional atraumatic restorative treatment - Dental Caries | Phase 4 | Completed | Ain Shams University | 100 | 2020-08-03 | 2022-02-23 |
| Evaluation Of Fluoride Uptake By Dentine Following Silver Diamine Fluoride Under Resin Modified Glass Ionomer Restoration In Carious Primary Molars Silver diamine fluoride - Dental Caries | Phase 4 | Completed | Cairo University | 20 | 2020-08-01 | 2021-03-08 |
| Sedation Versus Protective Stabilization for Pediatric Dental Treatment Ketamine 50 MG/ML, Midazolam Hcl 2Mg/Ml Syrup, Protective stabilization - Child Behavior, Dental Caries in Children | Phase 4 | Recruiting | Universidade Federal de Goias | 152 | 2020-01-30 | 2024-12-10 |
| Pulp Capping in Primary Molars Using TheraCal (LC) Light cured tri-calcium silicate base material - Deep Caries, Indirect Pulp Capping | Phase 4 | Completed | Ain Shams University | 40 | 2019-09-01 | 2023-02-03 |
| EVALUATION OF AN ALTERNATIVE TECHNIQUE FOR THE APPLICATION OF SODIUM FLUOROPHOSPHATE: A 2-YEARS DOUBLE-BLIND RCT Fluoride - Caries,Dental | Phase 4 | Completed | University of Buenos Aires | 300 | 2017-04-01 | 2023-04-12 |
| Comparison of ACTIVA BioACTIVE Versus Compomer in Restoring Dental Decay in Primary Molar Teeth ACTIVA™ BioACTIVE, Compomer - Dental Caries in Children | Phase 4 | Completed | University Ghent | 35 | 2017-01-01 | 2023-11-22 |
| Indirect Pulp Treatment in Primary Molars Indirect pulp treatment using Dycal (TM), Indirect pulp treatment using Vitrebond (TM ) - Dental Caries | Phase 4 | Completed | Cairo University | 88 | 2016-08-01 | 2019-08-30 |
| Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing analgesic mouth rinses (dissolved Aspirin), Normal saline rinses. - Periodontitis, Dental Caries | Phase 4 | Completed | Aga Khan University | 66 | 2016-05-01 | 2016-10-03 |
| Casein Phosphopeptide--amorphous Calcium Phosphate on Human Enamel Subjected to in Vivo Acid Attacks CPP-ACP, Placebos - Dental Erosion | Phase 4 | Completed | Fujian Medical University | 12 | 2015-12-25 | 2018-02-08 |
| Oral Fluoride Bioavailability by the Consumption of Meals Prepared With Fluoridated Water or Salt Meal - Fluoridation | Phase 4 | Completed | University of Campinas, Brazil | 12 | 2015-07-01 | 2017-05-09 |
| Midazolam and Ketamine Effect Administered Through the Nose for Sedation of Children for Dental Treatment Intranasal ketamine, Oral ketamine, Intranasal midazolam - Child Behavior, Dental Caries | Phase 4 | Completed | Universidade Federal de Goias | 84 | 2015-05-21 | 2018-04-30 |
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Dental Caries (44) · Child Behavior (5) · Gingivitis (3) · Periodontal Diseases (2) · Plaque, Amyloid (2) · Communicable Diseases (1) · Fluorosis, Dental (1) · Hypertension (1) · Periodontitis (1) · Pneumonia (1) · Tooth Erosion (1)
Stomatognathic Diseases (46) · Tooth Diseases (46) · Behavior (5) · Mouth Diseases (5) · Infections (4) · Gingival Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Periodontal Diseases (3) · Pathological Conditions, Anatomical (2) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Dental Enamel Hypomineralization (1) · Developmental Defects of Enamel (1)
Sodium Fluoride (5) · sodium fluoride topical preparation (4) · Ketamine (3) · Midazolam (3) · casein phosphopeptide-amorphous calcium phosphate nanocomplex (3) · silver diamine fluoride (3) · Behavior Therapy (2) · Fluorides (2) · Xylitol (2) · Bifluorid 12 (1) · Cetylpyridinium (1) · Chewing Gum (1) · Chlorhexidine (1) · Compomers (1) · Control Groups (1)
King Abdulaziz University (4) · Universidade Federal de Goias (3) · Ain Shams University (2) · Cairo University (2) · GlaxoSmithKline (2) · University of Campinas, Brazil (2) · Università degli Studi di Sassari (2) · Aga Khan University (1) · Assistance Publique - Hôpitaux de Paris (1) · Beirut Arab University (1) · Colgate Palmolive (1) · Didem Sakaryali (1) · Dow University of Health Sciences (1) · Federal University of Paraíba (1) · Fujian Medical University (1)
Egypt (5) · Brazil (4) · Saudi Arabia (4) · United States (3) · Israel (2) · Italy (2) · Pakistan (2) · United Kingdom (2) · Argentina (1) · Belgium (1) · Canada (1) · Chile (1) · China (1) · Finland (1) · France (1)
Luciane R Costa, DDS, MS, PhD (2) · Abla Ah Aly, A. Lecturer (1) · Adriana DB Rosa, student (1) · Alev Alacam, DDS, PhD (1) · Anas Imran Arshad, MSc., BDS (1) · Cristian P Basili, DDS, PHD (1) · Cristiana M Jesus-Franca, DDS, PhD (1) · Daniela P Raggio, PhD (1) · Denise E Antunes, DDS, PhD (1) · Dr Saba Arshad (1) · Dr. Turki S Abujamel, BDS, MSc, PhD (1) · Dr.Ahmad Holiel, Assis.Prof (1)
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