87 completed, 36 unknown, 23 not yet recruiting, 15 recruiting. 118 Not applicable, 12 Phase 1, 7 Phase 2, 6 Phase 4, 3 Phase 3.
Follow Developmental Defects of Enamel: new trials by email Literature Review of Developmental Defects of Enamel trials Research Report on Developmental Defects of Enamel
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Ain Shams University | 45 | 2027-05-01 | 2026-09-17 |
| Clinical Performance of Glass Hybrid and Alkasite Restorative Systems in MIH-Affected Permanent First Molars Alkasite Restorative System, Glass Hybrid Restorative System - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Çanakkale Onsekiz Mart University | 30 | 2026-12-31 | 2026-10-30 |
| Direct Composite Versus Indirect Hybrid Resin Restorations in Hypomineralized First Permanent Molars 3d printed restoration, composite - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Cairo University | 40 | 2026-10-01 | 2026-07-21 |
| Esthetic Impact of Different Minimally Invasive Approaches on Hypomineralized Permanent Anterior Teeth ICON® resin infiltration, Opalustre® enamel microabrasion, Antivet® enamel micro-abrasion - Enamel Hypomineralization, Dental | Not applicable | Not yet recruiting | Shaimaa Abdelrahman | 69 | 2026-10-01 | 2026-10-30 |
| Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization Computer-Controlled Local Anesthesia, Conventional Local Anesthesia - Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Marmara University | 54 | 2026-08-11 | 2026-07-29 |
| Aesthetic Masking and Resin Infiltration Time in MIH-affected Incisors macroabrasion followed by oxidative pretreatment, macroabrasion alone - Molar Incisor Hypomineralization | Not applicable | Not yet recruiting | Alexandria University | 100 | 2026-08-10 | 2026-08-07 |
| Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions Sodium hypochlorite 5.25%, CPP-ACPF - Molar Incisor Hypomineralization | Not applicable | Not yet recruiting | Universidade Ceuma | 54 | 2026-08-01 | 2026-07-08 |
| Assessment of Peridontal Inflamatuar Markers in MIH Initial periodontal treatment - Molar-Incisor Hypomineralization (MIH) | Not yet recruiting | Marmara University | 76 | 2026-07-16 | 2026-07-14 | |
| The Effectiveness of Antivet Versus Opalustre® for the Management of Enamel Fluorosis/Discolored Enamel and Its Impact on Aesthetic Outcomes. Antivet, Opalusture - Fluorosis, Dental, Enamel Discoloration | Not applicable | Completed | October University for Modern Sciences and Arts | 59 | 2026-05-18 | 2026-07-16 |
| Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization Glass Hybrid Restorative Treatment - Molar-Incisor Hypomineralization (MIH), Masticatory Performance | Not applicable | Not yet recruiting | Marmara University | 68 | 2026-05-11 | 2026-06-04 |
| Pain Assessment Governing Partial or Full Pulpotomy of Immature Molars With Irreversible Pulpitis in Molar Incisor Hypomineralization pulpotomy for MIH affected immature PFMs, partial pulpotomy for MIH affected immature PFMs, pulpotomy for non-MIH affected immature PFMs - Molar Incisor Hypomineralisation, Irreversible Pulpitis | Not applicable | Active not recruiting | Alaa Khafagy | 132 | 2026-05-01 | 2026-10-01 |
| Total Pulpotomy With Two Repair Cements in Hypomineralized Teeth MTA group, CIMMO DTA® group - Molar-Incisor Hypomineralization (MIH) | Not applicable | Active not recruiting | Meire Coelho Ferreira | 120 | 2026-04-16 | 2026-08-20 |
| Clinical Severity of Dental Fluorosis and Associated Risk Factors Among a Group of Children in Rural Region, Dendera Center in Egypt Dental Fluorosis | Not yet recruiting | Cairo University | 231 | 2026-02-20 | 2025-08-22 | |
| Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars Standard Local Anesthesia, Intraoral Cryotherapy, Silver Diamine Fluoride (SDF) - MIH, Molar-Incisor Hypomineralization | Not applicable | Not yet recruiting | Çanakkale Onsekiz Mart University | 75 | 2026-02-01 | 2026-01-08 |
| Preemptive Analgesia for Pain and Anxiety Control in Children With MIH ibuprofen 100mg/ml oral suspension syrup, Placebo - Pain and Anxiety in Children With MIH | Not applicable | Recruiting | October University for Modern Sciences and Arts | 46 | 2026-02-01 | 2026-01-28 |
| The Effect of Salvadora Persica (Miswak) Compared to Fluoridated Toothpaste on Children's Teeth Diagnosed With Molar-Incisor Hypomineralization (MIH): A Randomized Clinical Trial Salvadora persica (miswak), Fluoridated Toothpaste - Molar Incisor Hypomineralisation | Not applicable | Not yet recruiting | King Abdulaziz University | 30 | 2026-01-29 | 2026-01-21 |
| Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization Molar Incisor Hypomineralization | Completed | Lokman Hekim University | 91 | 2026-01-26 | 2026-08-31 | |
| Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study Graphene-reinforced CAD/CAM polymer (G-CAM®) - Tooth Demineralization, Tooth Sensitivity | Not applicable | Not yet recruiting | Universitat Internacional de Catalunya | 30 | 2026-01-10 | 2026-01-09 |
| Correlation Between Colour and Hypersensitivity of First Permanent Molars With Molar Incisor Hypomineralisation (MIH) Molar Incisor Hypomineralisation | Recruiting | University of Basel | 45 | 2026-01-09 | 2026-07-27 | |
| Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH) Molar Incisor Hypomineralisation, Enamel Breakdown | Recruiting | University of Basel | 45 | 2026-01-09 | 2026-07-27 |
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Molar Hypomineralization (132) · Fluorosis, Dental (22) · Dental Enamel Hypomineralization (20) · Dental Caries (18) · Dental Enamel Hypoplasia (10) · Dentin Sensitivity (10) · Amelogenesis Imperfecta (8) · Hypersensitivity (8) · Toothache (5) · Fluoride Poisoning (4) · Pain (4) · Dental Plaque (3) · Tooth Erosion (3) · Van der Woude syndrome (3) · Anxiety Disorders (2)
Congenital Abnormalities (180) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (180) · Stomatognathic System Abnormalities (180) · Tooth Diseases (180) · Tooth Abnormalities (179) · Stomatognathic Diseases (178) · Dental Enamel Hypomineralization (148) · Tooth Demineralization (20) · Pathological Conditions, Signs and Symptoms (12) · Immune System Diseases (9) · Signs and Symptoms (9) · Neurologic Manifestations (8) · Facial Pain (5) · Behavior (4)
Low-Level Light Therapy (6) · Enamel Microabrasion (3) · Fluorides, Topical (3) · Toothpastes (3) · opalustre (3) · Blood Specimen Collection (2) · Laser Therapy (2) · Pulpotomy (2) · casein phosphopeptide-amorphous calcium phosphate nanocomplex (2) · Analgesia (1) · Anesthesia, Local (1) · Apexification (1) · Biological Products (1) · Composite Resins (1) · Control Groups (1)
Cairo University (27) · Marmara University (9) · University of Nove de Julho (7) · Alexandria University (6) · Ain Shams University (5) · Hacettepe University (5) · University of Sao Paulo (5) · King Abdullah University Hospital (4) · Latakia University (4) · Assistance Publique - Hôpitaux de Paris (3) · Istanbul University (3) · King Abdulaziz University (3) · October University for Modern Sciences and Arts (3) · University of Campinas, Brazil (3) · University of Pavia (3)
Turkey (Türkiye) (38) · Egypt (35) · Brazil (19) · France (6) · Italy (6) · Jordan (6) · Syria (5) · Mexico (3) · Spain (3) · United States (3) · Vietnam (3) · Colombia (2) · Pakistan (2) · Saudi Arabia (2) · Switzerland (2)
Livia MA Tenuta, PhD (3) · Nabih Raslan, Dr (3) · Carlalberta Verna, Professor Dr.med.dent. (2) · Mai Haidar, Dr (2) · Meire C. Ferreira, PhD (2) · Milena Cadenaro, MD (2) · Ola B. Al-Batayneh (2) · Abdulrhman S Hakmi (1) · Abeer Abd Elatiif, professor (1) · Abla A. Aly, Phd (1) · Agneta Robertson (1) · Alaa Mo Yehia, Ass. Lec (1) · Aline Castilho, DDS (1) · Alp Abidin Atesci, PhD (1)
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