33 completed, 8 recruiting, 4 enrolling by invitation, 4 not yet recruiting. 59 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 59 | Completed 33, Recruiting 8, Enrolling by invitation 4, Not yet recruiting 4, Active not recruiting 3, Unknown 3, Terminated 2, Withdrawn 2 |
Follow Substance Use Disorder: new trials by email Literature Review of Substance Use Disorder trials Research Report on Substance Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Employing Peer Outreach and Whole Health in Recovery for Homeless-Experienced Veterans Employing Peer Outreach and Whole Health in Recovery (EMPOWER) - Substance Use Disorder, Mental Health Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 278 | 2027-01-01 | 2026-10-02 |
| Transforming Trauma Care Trauma Resilience and Recovery Program Portal 2.0 (TRRP 2.0) - Post-Traumatic Stress Disorder (PTSD), Depression | Not applicable | Not yet recruiting | Medical University of South Carolina | 300 | 2026-12-01 | 2026-09-21 |
| Homeless Overdose Prevention- Expansion Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity - Homelessness, Opioid Education and Naloxone Distribution (OEND) | Not applicable | Not yet recruiting | VA Office of Research and Development | 1200 | 2026-10-15 | 2026-10-05 |
| PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial) PATH (Peer Advanced Training for total Health) - Burnout, Secondary Trauma | Not applicable | Enrolling by invitation | Chestnut Health Systems | 200 | 2026-10-12 | 2026-10-27 |
| Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO - Methamphetamine Use Disorder, Substance Use Disorder | Not applicable | Active not recruiting | Shanghai Mental Health Center | 5 | 2026-08-05 | 2026-10-26 |
| Closed-loop TMS for the Core Clinical Features of the Methamphetamine Use Disorder Closed-loop TMS, Conventional TMS, Random TMS - Methamphetamine Use Disorder, Substance Use Disorder | Not applicable | Not yet recruiting | Shanghai Mental Health Center | 21 | 2026-08-01 | 2026-08-19 |
| Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retention Among Child Welfare Workers and Peer Supporters, and Implementation of Evidence Based Interventions. COSTARS, Implementation As Usual - Substance Use Disorder, Opioid Use Disorder | Not applicable | Enrolling by invitation | Alicia Bunger | 200 | 2026-07-28 | 2026-07-13 |
| Honest, Open, Proud (HOP): A Peer Delivered, Co-occurring Disorders Intervention for Justice-involved Veterans Veterans Affairs-Honest, Open, Proud - Stigma, Co-Occurring Disorders | Not applicable | Recruiting | VA Office of Research and Development | 240 | 2026-07-01 | 2026-08-03 |
| A Type I Hybrid Effectiveness-Implementation Trial of MIO Mothering from the Inside Out - Substance Use Disorder | Not applicable | Recruiting | Baystate Medical Center | 200 | 2025-12-23 | 2026-07-08 |
| A Digital Intervention to Decrease Self-Stigma Among Pregnant and Postpartum Women With Substance Use Disorder Enhearten with EMI, Waitlist Control Group - Substance Use Disorder | Not applicable | Recruiting | Washington University School of Medicine | 152 | 2025-11-24 | 2025-11-26 |
| Personalized Approach to Healthy Use and Recovery (PATH) Trial Personal Causal Model + Personalized Feedback - Substance Use Disorder | Not applicable | Recruiting | VA Office of Research and Development | 74 | 2025-10-01 | 2026-01-15 |
| Neuromodulation in Substance Use Disorders NaviFus Model101 - Substance Use Disorder | Not applicable | Active not recruiting | Manish Ranjan | 20 | 2025-08-07 | 2025-10-20 |
| Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction Real-time fMRI Neurofeedback, Sham Real-time fMRI Neurofeedback - Opioid Use Disorder, Substance Use Disorder | Not applicable | Completed | Icahn School of Medicine at Mount Sinai | 28 | 2025-05-20 | 2026-10-21 |
| Workforce and System Change to Treat Adolescent Opioid Use Disorder Within Integrated Pediatric Primary Care Integrated Behavioral Health System with SUD Resources - Substance Use Disorder, Opioid Use Disorder | Not applicable | Enrolling by invitation | Indiana University | 400 | 2025-02-21 | 2026-08-03 |
| Smoking Cessation CM for Veterans With or at Risk for Cancer Focus Group, Contingency Management (CM), TUD Treatment as Usual (TAU) - Tobacco Use Disorder, Substance Use Disorder | Not applicable | Recruiting | VA Office of Research and Development | 108 | 2025-01-29 | 2026-10-02 |
| Study on the Effectiveness of Journaling as an add-on to Cognitive Behavioral Therapy Journaling, Treatment as Usual (TAU) - Affective Disorders, Rumination | Not applicable | Enrolling by invitation | University Hospital Tuebingen | 80 | 2024-11-20 | 2026-04-08 |
| VR Based Therapy to Treat Anxiety in Dual Diagnosis Cognitive Miljeu Therapy, Virtual Reality based CBT for Anxiety - Dual Diagnosis, Psychosis | Not applicable | Unknown | Mental Health Centre Sct. Hans | 30 | 2024-11-01 | 2024-03-18 |
| Virtual MOUD Treatment- Virtual POC Toxicology Virtual POC Toxicology Test - Substance Use Disorder | Not applicable | Withdrawn | VA Office of Research and Development | 2023-09-01 | 2023-12-27 | |
| Peer Recovery Support Services for Individuals in Recovery Residences on MOUD Treatment as Usual (TAU) (Arm 1), Peer Recovery Support Services (PRSS) + TAU (experimental- Arm 2) - Opioid Use Disorder, Substance Use Disorder | Not applicable | Active not recruiting | Potomac Health Foundations | 50 | 2023-07-14 | 2025-04-09 |
| The Effectiveness of Mindfulness-based Relapse Prevention Mindfulness-based Relapse Prevention - Substance Use Disorder | Not applicable | Completed | Sir Run Run Shaw Hospital | 1200 | 2023-06-10 | 2025-04-01 |
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Substance-Related Disorders (59) · Stress Disorders, Post-Traumatic (9) · Depression (8) · Mental Disorders (8) · Anxiety Disorders (7) · Psychological Well-Being (7) · Behavior, Addictive (6) · Opioid-Related Disorders (6) · Alcoholism (5) · Mood Disorders (4) · Tobacco Use Disorder (4) · Tobacco Smoking (3) · Acquired Immunodeficiency Syndrome (2) · Cigarette Smoking (2) · Motor Activity (2)
Chemically-Induced Disorders (59) · Mental Disorders (51) · Behavior (21) · Behavioral Symptoms (9) · Stress Disorders, Traumatic (9) · Trauma and Stressor Related Disorders (9) · Personal Satisfaction (7) · Compulsive Behavior (6) · Impulsive Behavior (6) · Narcotic-Related Disorders (6) · Alcohol-Related Disorders (5) · Pathological Conditions, Signs and Symptoms (5) · Nervous System Diseases (4) · Respiratory Tract Diseases (4) · Blood-Borne Infections (3)
Therapeutics (3) · Standard of Care (2) · Case Management (1) · Continuous Positive Airway Pressure (1) · Focus Groups (1) · Interviews as Topic (1) · N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium (1) · Person-Centered Psychotherapy (1) · Salvage Therapy (1) · Tobacco Use Cessation Devices (1) · Transcranial Direct Current Stimulation (1) · elastin microfibril interface located protein (1)
VA Office of Research and Development (16) · University of California, Davis (3) · Click Therapeutics, Inc. (2) · Shanghai Mental Health Center (2) · Alicia Bunger (1) · Barbara A Rakel (1) · Baystate Medical Center (1) · Chestnut Health Systems (1) · Ege University (1) · Friends Research Institute, Inc. (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Icahn School of Medicine at Mount Sinai (1) · Indiana University (1) · IrisZorg (1) · Johns Hopkins University (1)
United States (45) · China (3) · Spain (2) · Germany (1) · India (1) · Netherlands (1) · Portugal (1) · Switzerland (1) · Turkey (Türkiye) (1)
Daniel M. Blonigen, PhD MA (3) · David A. Smelson, PsyD (2) · James P. LePage, PhD (2) · Abigail W Batchelder, PhD, MPH (1) · Alex T Ramsey, Ph.D. (1) · Allen L. Gifford, MD (1) · Amanda M. Midboe, PhD (1) · Amit Punia, LLB (1) · Amy C Janes, Ph.D. (1) · Ann-Christine Ehlis, Dr. (1) · Anne G. Sadler, PhD RN (1) · Barbara Rakel, PhD (1) · Benjamin Arnfred, phd (1) · Benjamin Littenberg, MD (1) · Brian M Iacoviello, PhD (1)
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