56 completed, 12 recruiting, 11 terminated, 10 unknown. 108 Phase 1, 39 Phase 2.
Follow Spinal Diseases: new trials by email Literature Review of Spinal Diseases trials Research Report on Spinal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease | Phase 1 | Not yet recruiting | Kolon TissueGene, Inc. | 24 | 2027-01-19 | 2026-08-20 |
| SCLife®-LDD hUC-MSCs Injection Therapy for Patients With Lumbar Intervertebral Disc Degeneration human umbilical cord mesenchymal stem cell suspension, total endoscopic extraction of lumbar nucleus pulposus - Lumbar Disc Degeneration | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 20 | 2026-12-31 | 2026-04-27 |
| Phase Ia Study of MST-931 in Healthy Adult Subjects MST-931, MST-931 Placebo - Ankylosing Spondylitis (AS) | Phase 1 | Recruiting | Mabsoft Therapeutics (Shanghai) Co., Ltd. | 32 | 2026-11-30 | 2026-11-03 |
| Comparing the Extent to Which Apremilast is Made Available in the Body After Administration as an Extended-release or Immediate-release Formulation Apremilast XR, Apremilast IR - Psoriasis, Arthritis, Psoriatic | Phase 1 | Not yet recruiting | Amgen | 114 | 2026-11-18 | 2026-11-02 |
| A Study of GKL-006Allo Injection in Patients With Ankylosing Spondylitis GKL-006Allo - Ankylosing Spondylitis | Phase 1 | Not yet recruiting | Beijing Gene Key Life Technology Co., Ltd | 12 | 2026-11-01 | 2026-11-04 |
| A Study to Evaluate Pharmacokinetics of DRL_AB in Healthy Male Participants DRL_AB - Healthy Volunteers | Phase 1 | Not yet recruiting | Dr. Reddy's Laboratories Limited | 160 | 2026-08-19 | 2026-08-04 |
| Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration High Dose, Low Dose - Disc Degenerative Disease, Back Pain | Phase 1 / Phase 2 | Not yet recruiting | Cartago Biotech Pty Ltd | 60 | 2026-07-04 | 2026-06-25 |
| Safety and Efficacy of Allogeneic Bone Marrow MSCs in Ankylosing Spondylitis IV administration of CG-BM1, Placebo, CG-BM1 - Ankylosing Spondylitis | Phase 1 | Not yet recruiting | Eighth Affiliated Hospital, Sun Yat-sen University | 40 | 2026-07-01 | 2026-06-08 |
| Study of S-4321 in Participants With an Autoimmune or Immune-mediated Disease S-4321 - Autoimmune Diseases, Rheumatoid Arthritis (RA) | Phase 1 | Recruiting | Seismic Therapeutic AU Pty Ltd | 24 | 2026-06-01 | 2026-06-01 |
| Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury EC5026 oral tablet, Placebo oral tablet - Spinal Cord Injuries, Neuropathic Pain | Phase 1 | Recruiting | EicOsis Human Health Inc. | 36 | 2026-05-01 | 2026-07-10 |
| A Phase I/Ⅱ Clinical Trial for Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in the Treatment of Ankylosing Spondylitis HS_SW01 cells injection - Ankylosing Spondylitis | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Huishan Biotechnology Co., Ltd. | 18 | 2026-04-10 | 2026-04-20 |
| A Study of HB0017 Injection in Healthy Volunteers to Evaluate Safety and Tolerability of a Single Subcutaneous Injection in Low-Body-Weight Subjects; and Pharmacokinetics at Different Subcutaneous Injection Sites at the Same Dose HB0017 Injection, HB0017 Placebo - Psoriasis, Ankylosing Spondylitis | Phase 1 | Recruiting | Huabo Biopharm Co., Ltd. | 90 | 2026-01-19 | 2026-11-06 |
| A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults Bimekizumab regimen 1 iv, Bimekizumab regimen 2 iv, Bimekizumab regimen 3 sc - Psoriatic Arthritis, Axial Spondyloarthritis | Phase 1 | Recruiting | UCB Biopharma SRL | 392 | 2025-12-10 | 2026-11-06 |
| A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab) Bimekizumab - Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis | Phase 1 | Recruiting | UCB Biopharma SRL | 20 | 2025-11-05 | 2026-09-18 |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease aNPC - Intervertebral Disc Degeneration | Phase 1 / Phase 2 | Recruiting | ASTEROGENE Biomedical Co. Ltd. | 12 | 2025-09-26 | 2026-04-03 |
| EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1) Part A - Single Ascending Dose (SAD) in Healthy Human Volunteers, Part B - Multiple Ascending Dose (MAD) in participants with axSpA, Part C - Safety expansion cohort in participants with axSpA - Axial Spondyloarthritis (AxSpA) | Phase 1 / Phase 2 | Recruiting | Grey Wolf Therapeutics | 140 | 2025-07-28 | 2026-11-12 |
| Mesenchymal Stem Cells Infusion in Patients With Autoimmune Diseases Mesenchymal Stem Cells, Placebo - Rheumatoid Arthritis, Systemic Lupus Erythematosus (SLE) | Phase 1 / Phase 2 | Enrolling by invitation | National Institute of Blood and Marrow Transplant (NIBMT), Pakistan | 200 | 2025-02-01 | 2025-03-21 |
| Safety and Pharmacokinetics of LPX-TI641 in Rheumatoid Arthritis and Psoriatic Arthritis LPX-TI641, Placebo - Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA) | Phase 1 | Active not recruiting | LAPIX Therapeutics Inc. | 48 | 2024-12-15 | 2026-10-30 |
| LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF) LDGraft, Allograft Bone - Degenerative Disc Disease, Lumbar Disc Disease | Phase 1 / Phase 2 | Recruiting | Locate Bio Pty Ltd | 40 | 2024-11-12 | 2026-08-26 |
Showing 20 of 108. Sign in to see all of them.
Arthritis, Psoriatic (31) · Intervertebral Disc Degeneration (30) · Spondylitis, Ankylosing (20) · Arthritis, Rheumatoid (14) · Intervertebral Disc Displacement (9) · Psoriasis (9) · Spondylolisthesis (8) · Axial Spondyloarthritis (7) · Crohn Disease (7) · Spinal Stenosis (7) · Autoimmune Diseases (6) · Low Back Pain (6) · Arthritis (5) · Inflammatory Bowel Diseases (5)
Bone Diseases (108) · Musculoskeletal Diseases (106) · Joint Diseases (54) · Spondylitis (53) · Spondylarthritis (51) · Arthritis (50) · Spondylarthropathies (50) · Skin and Connective Tissue Diseases (37) · Skin Diseases (35) · Skin Diseases, Papulosquamous (33) · Ankylosis (25) · Pathological Conditions, Signs and Symptoms (25) · Psoriasis (24) · Immune System Diseases (19)
Infliximab (3) · deucravacitinib (3) · Certolizumab Pegol (2) · Genes, mos (2) · Methadone (2) · Methotrexate (2) · Saline Solution (2) · Spinal Fusion (2) · bimekizumab (2) · Adalimumab (1) · BCD-055 (1) · CTLA-4 Antigen (1) · Clonidine (1) · Contraceptives, Oral (1) · Dexamethasone (1)
Bristol-Myers Squibb (4) · DePuy Spine (3) · Mesoblast, Ltd. (3) · UCB Biopharma SRL (3) · Bio-Thera Solutions (2) · BioSurface Engineering Technologies, Inc (2) · Celltrion (2) · DiscGenics, Inc. (2) · M.D. Anderson Cancer Center (2) · National Taiwan University Hospital (2) · Red de Terapia Celular (2) · UCB BIOSCIENCES, Inc. (2) · ASTEROGENE Biomedical Co. Ltd. (1) · ActiveO Inc. (1) · Advanced Accelerator Applications (1)
United States (40) · China (11) · Australia (10) · Canada (7) · Germany (6) · Netherlands (6) · South Korea (5) · Spain (5) · Switzerland (5) · Poland (4) · France (3) · Taiwan (3) · Austria (2) · Belgium (2) · Brazil (2)
Amol J. Ghia, MD (2) · Donna Skerrett, MD (2) · Won Park, M.D., Ph.D. (2) · Alison Heald, MD (1) · Ana Sanchez, MD, PhD (1) · Andreas Klostermann, Dr. (1) · Anthony Opipari, MD, PhD (1) · Athos Patsalides (1) · Brent Atkinson, PhD (1) · Christian Raftopoulos, MD, PhD (1) · Chunde Bao (1)
PMID 31442616, PMID 10360702, PMID 10488513, PMID 11050032, PMID 11172169, PMID 12709856, PMID 15084121, PMID 16227895, PMID 17077737, PMID 17256032, PMID 17978354, PMID 19587341, PMID 19830485, PMID 20231202, PMID 20460997, PMID 22225488, PMID 22285199, PMID 23300829, PMID 25769789, PMID 26795209, PMID 26920137, PMID 27117698, PMID 27661661, PMID 28814432, PMID 29030361, PMID 29275332, PMID 32905628, PMID 33207794, PMID 33241960, PMID 33945627, PMID 34284523, PMID 35262901, PMID 35470301, PMID 35921598, PMID 38925869, PMID 41915069, PMID 42012633
2017 (2), 2016 (1), 2023 (1), 2025 (1), UM1CA186688 (1)