107 completed, 41 unknown, 28 terminated, 18 recruiting. 221 Phase 2, 39 Phase 1, 28 Phase 3.
Follow Spinal Diseases: new trials by email Literature Review of Spinal Diseases trials Research Report on Spinal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Extension Study of Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic Arthritis (CDDY391A12201-extension) DDY391 - Moderate to Severe Psoriatic Arthritis | Phase 2 | Not yet recruiting | Novartis Pharmaceuticals | 88 | 2027-02-10 | 2026-11-06 |
| Phase 2 Trial of FT2109 for the Treatment of Psoriatic Arthritis FT2109 Dosing Regimen 1, FT2109 Dosing Regimen 2, Matching Placebo - Psoriatic Arthritis (PsA) | Phase 2 | Not yet recruiting | Forward Therapeutics | 210 | 2026-12-01 | 2026-10-09 |
| A Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic Arthritis DDY391, Placebo - Moderate to Severe Psoriatic Arthritis | Phase 2 | Recruiting | Novartis Pharmaceuticals | 220 | 2026-10-19 | 2026-11-09 |
| Vilamakitug in Spondyloarthritis Placebo-controlled Investigation for Efficacy vilamakitug, placebo - Axial Spondyloarthritis, Ankylosing Spondylitis | Phase 2 | Not yet recruiting | XBiotech, Inc. | 150 | 2026-09-01 | 2026-05-14 |
| A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis TQH3906 Capsule, TQH3906 Placebo Capsule, Tofacitinib Citrate Tablet 5 mg - Psoriatic Arthritis | Phase 2 | Recruiting | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 156 | 2026-07-16 | 2026-09-02 |
| Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration High Dose, Low Dose - Disc Degenerative Disease, Back Pain | Phase 1 / Phase 2 | Not yet recruiting | Cartago Biotech Pty Ltd | 60 | 2026-07-04 | 2026-06-25 |
| Oral CBP-0276 or Placebo in Adults With Active Psoriatic Arthritis (PsA) CBP-0276 capsules 100mg, Placebo - Arthritic Psoriasis | Phase 2 | Not yet recruiting | Clarent Biopharma, Inc. | 240 | 2026-07-01 | 2026-07-16 |
| Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015) Tulisokibart, Placebo - Psoriatic Arthritis | Phase 2 | Active not recruiting | Merck Sharp & Dohme LLC | 140 | 2026-04-20 | 2026-10-20 |
| A Phase I/Ⅱ Clinical Trial for Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in the Treatment of Ankylosing Spondylitis HS_SW01 cells injection - Ankylosing Spondylitis | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Huishan Biotechnology Co., Ltd. | 18 | 2026-04-10 | 2026-04-20 |
| Efficacy and Safety of Xeligekimab in the Treatment of Non-Radiographic Axial Spondyloarthritis Xeligekimab injection - Nr-axial Spondyloarthritis, Non-Radiographical Axial Spondyloarthritis | Phase 2 / Phase 3 | Not yet recruiting | Lingli Dong | 40 | 2026-01-31 | 2026-01-14 |
| A Phase II Study to Evaluate the Efficacy and Safety of D-2570 in Subjects With Active Psoriatic Arthritis D-2570, Placebo - PsA (Psoriatic Arthritis) | Phase 2 | Recruiting | InventisBio Co., Ltd | 222 | 2026-01-16 | 2026-04-22 |
| A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis JNJ-88545223, Placebo - Arthritis, Psoriatic | Phase 2 | Active not recruiting | Janssen Research & Development, LLC | 157 | 2026-01-15 | 2026-11-03 |
| A Study of Picankibart in Patients With Active Psoriatic Arthritis Placebo, Picankibart - Psoriatic Arthritis | Phase 2 / Phase 3 | Recruiting | Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. | 222 | 2025-12-18 | 2026-03-20 |
| Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty Methotrexate, Sulfasalazine, Hydroxychloroquine - Rheumatic Disease | Phase 2 | Recruiting | NYU Langone Health | 80 | 2025-12-12 | 2026-07-09 |
| IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study Ferric carboxymaltose IV, Normal Saline (Placebo) - Scoliosis Correction, Iron Deficiency | Phase 2 / Phase 3 | Recruiting | Columbia University | 120 | 2025-11-21 | 2025-11-26 |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease aNPC - Intervertebral Disc Degeneration | Phase 1 / Phase 2 | Recruiting | ASTEROGENE Biomedical Co. Ltd. | 12 | 2025-09-26 | 2026-04-03 |
| A Study of SPY072 in Rheumatic Disease SPY002-072, Placebo - Rheumatoid Arthritis, Psoriatic Arthritis | Phase 2 | Active not recruiting | Spyre Therapeutics, Inc. | 285 | 2025-08-21 | 2026-06-05 |
| EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1) Part A - Single Ascending Dose (SAD) in Healthy Human Volunteers, Part B - Multiple Ascending Dose (MAD) in participants with axSpA, Part C - Safety expansion cohort in participants with axSpA - Axial Spondyloarthritis (AxSpA) | Phase 1 / Phase 2 | Recruiting | Grey Wolf Therapeutics | 140 | 2025-07-28 | 2026-11-12 |
| Standard Dose Versus High Dose Stereotactic Spine Radiosurgery for Metastatic Spinal Neoplasms Spine Stereotactic Radiosurgery (SSRS) - Spinal Neoplasms | Phase 2 | Recruiting | National Taiwan University Hospital | 196 | 2025-06-01 | 2025-06-26 |
Showing 20 of 221. Sign in to see all of them.
Arthritis, Psoriatic (65) · Spondylitis, Ankylosing (57) · Intervertebral Disc Degeneration (40) · Arthritis, Rheumatoid (17) · Axial Spondyloarthritis (15) · Arthritis (14) · Low Back Pain (14) · Spinal Stenosis (14) · Intervertebral Disc Displacement (13) · Psoriasis (13) · Spondylarthritis (11) · Spondylolisthesis (11) · Scoliosis (9) · Back Pain (7)
Bone Diseases (219) · Musculoskeletal Diseases (216) · Joint Diseases (131) · Spondylitis (129) · Spondylarthropathies (124) · Spondylarthritis (123) · Arthritis (121) · Skin and Connective Tissue Diseases (71) · Ankylosis (70) · Skin Diseases (67) · Skin Diseases, Papulosquamous (67) · Axial Spondyloarthritis (56) · Psoriasis (54) · Pathological Conditions, Signs and Symptoms (45)
Etanercept (7) · tofacitinib (7) · Adalimumab (6) · Saline Solution (6) · bimekizumab (6) · risankizumab (5) · secukinumab (5) · GLPG0634 (4) · Infliximab (4) · Sulfasalazine (4) · Ustekinumab (4) · Abatacept (3) · Meloxicam (3) · Methotrexate (3) · Spinal Fusion (3)
Charite University, Berlin, Germany (11) · AbbVie (7) · Mesoblast, Ltd. (6) · Novartis Pharmaceuticals (6) · DePuy Spine (4) · Lakefront Biotherapeutics NV (4) · Amgen (3) · Janssen Research & Development, LLC (3) · M.D. Anderson Cancer Center (3) · Pfizer (3) · Tel-Aviv Sourasky Medical Center (3) · The Hospital for Sick Children (3) · UCB Biopharma SRL (3) · ACELYRIN Inc. (2) · Advanced Accelerator Applications (2)
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Roger Brown (4) · Joachim Sieper, MD (3) · Joachim Sieper, Prof. (3) · Amol J. Ghia, MD (2) · Donna Skerrett, MD (2)
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