22 completed, 9 unknown, 3 recruiting, 2 not yet recruiting. 23 Not applicable, 3 Phase 2, 3 Phase 4, 1 Early Phase 1, 1 Phase 1.
Follow Spasticity as Sequela of Stroke: new trials by email Literature Review of Spasticity as Sequela of Stroke trials Research Report on Spasticity as Sequela of Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity phenol neurolysis, Botulinum Toxin - A injections - Spasticity as Sequela of Stroke | Phase 4 | Not yet recruiting | Assiut University | 60 | 2026-05-01 | 2026-02-27 |
| Improving STEP in Stroke Patients REMARCHE® shoes, Sham REMARCHE® shoes - Stroke, Hemiplegia Following Ischemic Stroke | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 58 | 2026-03-01 | 2026-02-11 |
| Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System Cryoneurolysis - Spasticity as Sequela of Stroke | Not applicable | Recruiting | Sue Peters | 25 | 2025-08-01 | 2026-04-21 |
| Aromatherapy on Upper Limb Spasticity on Stroke Survivors massage oil with a mixture of sweet marjoram essential oil and fractionated coconut organic carrier oil, plain fractionated coconut organic carrier oil - Aromatherapy, Spasticity as Sequela of Stroke | Not applicable | Completed | Hong Kong Metropolitan University | 30 | 2025-02-01 | 2025-12-16 |
| Closed Loop Spinal Cord Stimulation for Neuromodulation of Upper Motor Neuron Lesion Spasticity Spinal Cord Stimulation- Closed loop - Chronic Pain, Spasticity as Sequela of Stroke | Withdrawn | Johns Hopkins University | 2024-12-03 | 2026-02-06 | ||
| Anti-Spastic Splint With Focal Muscle Vibration for Stroke Hand Spasticity Vibration plus anti-spastic hand splint, Anti-spastic hand splint, Vibration - Spasticity as Sequela of Stroke | Not applicable | Unknown | Arab American University (Palestine) | 48 | 2024-08-01 | 2024-04-15 |
| Muscle Oxygenation and Spasticity in Hemiparetic Stroke Patients Stroke, Hemiparesis;Poststroke/CVA | Completed | Ankara Medipol University | 30 | 2024-04-15 | 2025-05-21 | |
| Recovery of Motor Skills With the Use of Artificial Intelligence and Computer Vision AssistI patients, Habilect patients - Stroke, Hemiparesis | Not applicable | Unknown | Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health | 90 | 2024-02-01 | 2023-12-28 |
| Radial Extracorporeal Shock Wave Therapy as an Adjunct to Botulinum Toxin Type A for Post-Stroke Lower Limb Spasticity (SOLUTION) Radial shock Wave therapy (3000 pulses, 5 Hz, 2.5 bar)., ARM B: Sham-radial shock Wave therapy, Ultrasound-guided abobotulinumtoxin A - Stroke, Spasticity as Sequela of Stroke | Early Phase 1 | Completed | Parc de Salut Mar | 20 | 2024-02-01 | 2026-10-15 |
| Effect of ESWT Applied After Botulinum Toxin Injection on Ankle Spasticity in Stroke Patients. Radial Extracorporeal Shock Wave Therapy ONCE, Radial Extracorporeal Shock Wave Therapy TWİCE, Radial Extracorporeal Shock Wave Therapy SHAM - Stroke, Spasticity as Sequela of Stroke | Not applicable | Unknown | Saglik Bilimleri Universitesi | 30 | 2023-12-01 | 2023-12-26 |
| A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development Spasticity as Sequela of Stroke | Active not recruiting | Ipsen | 1057 | 2023-11-01 | 2026-09-04 | |
| Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy stereotactic radiosurgery (SRS) dorsal root rhizotomy radiomodulation, Sham - Spasticity as Sequela of Stroke, Spastic Cerebral Palsy | Not applicable | Recruiting | Ohio State University | 22 | 2023-10-12 | 2025-12-19 |
| Robotic Hand Rehabilitation Technological Group, Conventional Treatment - Stroke, Spasticity as Sequela of Stroke | Not applicable | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 24 | 2023-10-02 | 2024-12-13 |
| Fully Remote Use of IpsiHand Device in Hemiparetic Stroke Neurolutions IpsiHand Upper Extremity Rehabilitation System, Home Exercise rehabilitation regimen Program (HEP) - Stroke, Hemiparesis | Not applicable | Completed | Neurolutions, Inc. | 109 | 2023-10-01 | 2026-08-12 |
| Effects of Dry Needling on Electromyographic Activity and Ultrasonographic Characteristics in Post-Stroke Spasticity Dry needling + usual care, Sham dry needling + usual care - Spasticity as Sequela of Stroke | Not applicable | Completed | Universidad de Zaragoza | 28 | 2023-09-15 | 2026-09-14 |
| Mechanism of Action of Focal Extracorporeal Shock Waves as a Treatment of Upper Limb Stroke Spasticity: a Pilot Study Extracorporeal Shockwave Therapy - Stroke, Hemiparesis | Completed | Istituto Auxologico Italiano | 12 | 2023-05-30 | 2025-11-18 | |
| Different Treatment Methods Effect on Upper Extremity Spasticity and Decreased Functionality After Stroke Vibration, Modified Constraint-İnduced Movement Therapy, Conventional Therapy - Stroke, Spasticity as Sequela of Stroke | Not applicable | Completed | Zuhal Şevval Gökdere | 45 | 2023-01-10 | 2023-10-18 |
| EXOPULSE Mollii Suit, Motor Function & Stroke (EXOSTROKE) EXOPULSE MOLLII SUIT (active), EXOPULSE MOLLII SUIT (sham) - Spasticity as Sequela of Stroke | Not applicable | Completed | Institut De La Colonne Vertebrale Et Des Neurosciences | 30 | 2022-12-20 | 2026-02-27 |
| Comparison of Two Botox Injection Techniques to Improve Gait Botulinum toxin guided by ultrasonography and anatomical references, Botulinum neurotoxin guided by ultrasonography and in vivo location of innervation zones guided by high-density electromyography - Muscle Spasticity, Stroke Sequelae | Not applicable | Completed | Universidad de los Andes, Chile | 18 | 2022-07-01 | 2025-08-15 |
| Observational Longitudinal Study on the Outbreak and Management of Stroke Related Spasticity Botulinum toxin type A - Spasticity as Sequela of Stroke | Unknown | Campus Bio-Medico University | 960 | 2022-06-01 | 2022-05-23 |
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Stroke (23) · Muscle Spasticity (21) · Paresis (8) · Hemiplegia (7) · Gait Disorders, Neurologic (3) · Hemorrhagic Stroke (3) · Ischemic Stroke (3) · Brain Injuries (1) · Central Nervous System Diseases (1) · Cerebellar Ataxia (1) · Cerebral Palsy (1) · Chronic Pain (1) · Clubfoot (1) · Consciousness Disorders (1) · Contracture (1)
Nervous System Diseases (30) · Pathological Conditions, Signs and Symptoms (28) · Signs and Symptoms (28) · Neurologic Manifestations (27) · Brain Diseases (24) · Cardiovascular Diseases (23) · Central Nervous System Diseases (23) · Cerebrovascular Disorders (23) · Musculoskeletal Diseases (23) · Vascular Diseases (23) · Muscular Diseases (22) · Neuromuscular Manifestations (21) · Muscle Hypertonia (20) · Paralysis (7) · Ataxia (1)
Botulinum Toxins, Type A (4) · Vibration (2) · Botulinum Toxins (1) · Dry Needling (1) · Extracorporeal Shockwave Therapy (1) · Massage (1) · Pharmaceutical Preparations (1) · Radiosurgery (1) · Rehabilitation (1) · Saline Solution (1) · Spermine Synthase (1) · Transcranial Magnetic Stimulation (1) · salicylhydroxamic acid (1)
Ipsen (2) · Northwell Health (2) · Ankara Medipol University (1) · Arab American University (Palestine) (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Campus Bio-Medico University (1) · Carol Davila University of Medicine and Pharmacy (1) · Cheng-Hsin General Hospital (1) · Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Géraldine Martens (1) · Heng-Yi, Shen (1) · Hong Kong Metropolitan University (1) · Institut De La Colonne Vertebrale Et Des Neurosciences (1)
United States (7) · Turkey (Türkiye) (5) · Italy (4) · France (3) · Spain (3) · Canada (2) · Chile (2) · Austria (1) · Belgium (1) · Germany (1) · Hong Kong (1) · Malaysia (1) · Pakistan (1) · Palestinian Territories (1) · Romania (1)
Akhil Chhatre, MD (1) · Alexander Thiel, MD (1) · Alexandre Carter, MD, PhD (1) · Allison M Okamura, PhD (1) · Arlette P Doussoulin, PhD (1) · Bruce T Volpe, MD (1) · Galina Ivanova, Prof (1) · Hakan Gunduz, Prof (1) · Hisham Arab Alkabeya, PhD (1) · Joon-Ho Shin, MS (1) · Joshua Palmer, MD (1) · Marie-Helene Boudrias, PT, PhD (1)
PMID 11689982, PMID 12929197, PMID 19197564, PMID 22277759, PMID 22507444, PMID 25797650, PMID 29675072, PMID 31868130, PMID 32232101, PMID 33448755, PMID 35100025, PMID 36809647, PMID 37706171, PMID 38950995, PMID 39819949, PMID 40421840, PMID 40717605, PMID 42708130, PMID 7192811, PMID 8834110
2025 (1), R44HD105579 (1)